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Reversible Effects of Integrase Inhibitors on Newly Differentiated Adipocytes. [PDF]
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Adipogenesis and metabolic health
Nature Reviews Molecular Cell Biology, 2019Obesity is characterized by increased adipose tissue mass and has been associated with a strong predisposition towards metabolic diseases and cancer. Thus, it constitutes a public health issue of major proportion. The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes ...
Philipp Scherer
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Molecular Regulation of Adipogenesis
Annual Review of Cell and Developmental Biology, 2000▪ Abstract Adipogenesis, or the development of fat cells from preadipocytes, has been one of the most intensely studied models of cellular differentiation. In part this has been because of the availability of in vitro models that faithfully recapitulate most of the critical aspects of fat cell formation in vivo. More recently, studies of adipogenesis
Bruce M Spiegelman
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Phytochemicals and adipogenesis
BioFactors, 2010AbstractObesity is an increasing health problem all over the world. Phytochemicals are potential agents to inhibit differentiation of preadipocytes, stimulate lipolysis, and induce apoptosis of existing adipocytes, thereby reducing the amount of adipose tissue.
Andersen, Charlotte +3 more
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Human Pathology, 1970
Abstract The size of the fat depot provides a morphologic index of its metabolic activity. It may be tentatively generalized that the perirenal, epicardial, orbital, plantar, and cheek adipose tissues are metabolically less active than subcutaneous, mesenteric, omental, and eventually other internal depots.
U, Sigwart, L G, Tedeschi, C G, Tedeschi
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Abstract The size of the fat depot provides a morphologic index of its metabolic activity. It may be tentatively generalized that the perirenal, epicardial, orbital, plantar, and cheek adipose tissues are metabolically less active than subcutaneous, mesenteric, omental, and eventually other internal depots.
U, Sigwart, L G, Tedeschi, C G, Tedeschi
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Transcriptional activation of adipogenesis
Current Opinion in Cell Biology, 1999Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy balance systems, these factors provide ...
Z, Wu, P, Puigserver, B M, Spiegelman
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Proteome analysis of adipogenesis
PROTEOMICS, 2004AbstractAdipose tissue plays a crucial endocrine role in controlling whole body glucose homeostasis and insulin sensitivity. Given the substantial rise in obesity and obesity‐related diseases such as diabetes, it is important to understand the molecular basis of adipocyte differentiation and its control.
Welsh, GI +4 more
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Journal of Experimental Biology, 2018
ABSTRACT White adipose tissue (AT) is the main lipid storage depot in vertebrates. Initially considered to be a simple lipid store, AT has recently been recognized as playing a role as an endocrine organ that is implicated in processes such as energy homeostasis and as a rich source of stem cells.
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ABSTRACT White adipose tissue (AT) is the main lipid storage depot in vertebrates. Initially considered to be a simple lipid store, AT has recently been recognized as playing a role as an endocrine organ that is implicated in processes such as energy homeostasis and as a rich source of stem cells.
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Epigenetic regulation of adipogenesis
Current Opinion in Clinical Nutrition and Metabolic Care, 2012Epigenetic regulation plays an essential role in cell differentiation, by allowing the establishment and maintenance of the gene-expression pattern of the mature cell type. Because of its importance in chronic diseases, adipogenesis is one of the best-studied differentiation processes.
Melina M, Musri, Marcelina, Párrizas
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