Results 171 to 180 of about 4,022 (213)
Some of the next articles are maybe not open access.
Molecular Regulation of Adipogenesis
Annual Review of Cell and Developmental Biology, 2000▪ Abstract Adipogenesis, or the development of fat cells from preadipocytes, has been one of the most intensely studied models of cellular differentiation. In part this has been because of the availability of in vitro models that faithfully recapitulate most of the critical aspects of fat cell formation in vivo. More recently, studies of adipogenesis
Bruce Spiegelman, Evan Rosen
exaly +3 more sources
Journal of Experimental Biology, 2018
ABSTRACT White adipose tissue (AT) is the main lipid storage depot in vertebrates. Initially considered to be a simple lipid store, AT has recently been recognized as playing a role as an endocrine organ that is implicated in processes such as energy homeostasis and as a rich source of stem cells.
openaire +2 more sources
ABSTRACT White adipose tissue (AT) is the main lipid storage depot in vertebrates. Initially considered to be a simple lipid store, AT has recently been recognized as playing a role as an endocrine organ that is implicated in processes such as energy homeostasis and as a rich source of stem cells.
openaire +2 more sources
New developments in adipogenesis
Trends in Endocrinology & Metabolism, 2009The obesity epidemic has focused attention on adipose tissue and the development of fat cells (i.e. adipocytes), which is known as adipogenesis. Peroxisome proliferator-activated receptor gamma and CCAAT/enhancer-binding proteins have emerged as master regulators of adipogenesis, and recent genome-wide studies have indicated widespread overlap in their
Martina I, Lefterova, Mitchell A, Lazar
openaire +2 more sources
Transcriptional control of adipogenesis
Current Opinion in Cell Biology, 1998Adipocyte differentiation is coordinatedly regulated by several transcription factors. C/EBP beta, C/EBP delta and ADD-1/SREBP-1 are active early during the differentiation process and induce the expression and/or activity of the peroxisome proliferator activated receptor-gamma (PPAR gamma), the pivotal coordinator of the adipocyte differentiation ...
L, Fajas, J C, Fruchart, J, Auwerx
openaire +2 more sources
Epigenetic regulation of adipogenesis
Current Opinion in Clinical Nutrition and Metabolic Care, 2012Epigenetic regulation plays an essential role in cell differentiation, by allowing the establishment and maintenance of the gene-expression pattern of the mature cell type. Because of its importance in chronic diseases, adipogenesis is one of the best-studied differentiation processes.
Melina M, Musri, Marcelina, Párrizas
openaire +2 more sources
2017
In obesity, the process of adipogenesis largely determines the number of adipocytes in body fat depots. Adipogenesis is regulated by several adipocyte-selective microRNAs (miRNAs) and transcription factors that modulate adipocyte proliferation and differentiation. However, some miRNAs block expression of master regulators of adipogenesis. Additionally,
openaire +2 more sources
In obesity, the process of adipogenesis largely determines the number of adipocytes in body fat depots. Adipogenesis is regulated by several adipocyte-selective microRNAs (miRNAs) and transcription factors that modulate adipocyte proliferation and differentiation. However, some miRNAs block expression of master regulators of adipogenesis. Additionally,
openaire +2 more sources
Proteome analysis of adipogenesis
PROTEOMICS, 2004AbstractAdipose tissue plays a crucial endocrine role in controlling whole body glucose homeostasis and insulin sensitivity. Given the substantial rise in obesity and obesity‐related diseases such as diabetes, it is important to understand the molecular basis of adipocyte differentiation and its control.
Welsh, GI +4 more
openaire +3 more sources
Transcriptional Regulation of Adipogenesis
Comprehensive Physiology, 2017ABSTRACT Adipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that contributes to several important physiological processes, such as lipid metabolism, systemic energy homeostasis, and whole‐body insulin
Paula, Mota de Sá +3 more
openaire +2 more sources
Transcriptional activation of adipogenesis
Current Opinion in Cell Biology, 1999Studies from the past several years have revealed that adipogenesis is controlled by an interplay of transcription factors, including members of the CCAAT/enhancer binding protein family and peroxisome proliferator activated receptor gamma. In addition to providing a new understanding of this aspect of the energy balance systems, these factors provide ...
Z, Wu, P, Puigserver, B M, Spiegelman
openaire +2 more sources
Hormonal Regulation of Adipogenesis
Comprehensive Physiology, 2017ABSTRACT Adipose tissue includes multiple anatomical depots that serve as an energy reserve that can expand or contract to maintain metabolic homeostasis. During normal growth and in response to overnutrition, adipose tissue expands by increasing the volume of preexisting adipocytes (hypertrophy) and/or by ...
openaire +2 more sources