Results 81 to 90 of about 52,905 (310)

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Unveiling the perfect workout: exercise modalities and dosages to ameliorate adipokine dysregulation in individuals with overweight and obesity: a systematic review with pairwise, network, and dose–response meta-analyses

Frontiers in Nutrition
BackgroundObesity is commonly associated with dysregulation of adipokines, particularly characterized by elevated leptin levels and reduced adiponectin levels.
Hai Wang, Hao Wang, Enyan Zhan, Xiaodong Liu   +3 more
doaj   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source

Correlations between circulating adipokines and hepatocellular carcinoma: a Systematic Review and meta-analysis

Frontiers in Endocrinology
BackgroundHepatocellular carcinoma (HCC) is among the most common malignant tumors, characterized by high incidence and mortality rates. The role of adipokines in liver diseases is increasingly recognized and involves multiple contributing factors ...
Yani Ke, Yani Ke, Yani Ke, Yuyan Pan, Yuyan Pan, Yuyan Pan, Xueru Huang, Xueru Huang, Xueru Huang, Xing Bai, Xing Bai, Xing Bai, Xiaojuan Liu, Xiaojuan Liu, Xiaojuan Liu, Mingsi Zhang, Tao Jiang, Tao Jiang, Tao Jiang, Guangji Zhang, Guangji Zhang, Guangji Zhang   +21 more
doaj   +1 more source

Increased Release of Proinflammatory Proteins in Primary Human Adipocytes and Activation of the Inflammatory NFĸB, p38, and ERK Pathways upon Omentin Treatment

Obesity Facts, 2020
Objectives: To investigate the impact of omentin on the release of inflammation-related biomarkers and inflammatory pathways in primary human adipocytes. Methods: Adipocytes were treated with or without omentin (500 and 2,000 ng/mL), and the supernatants
Corinna Niersmann, Karin Röhrig, Matthias Blüher, Michael Roden, Christian Herder, Maren Carstensen-Kirberg   +5 more
doaj   +1 more source

Pancreatic exocrine insufficiency after bariatric surgery [PDF]

, 2017
Morbid obesity is a lifelong disease, and all patients require complementary follow-up including nutritional surveillance by a multidisciplinary team after bariatric procedures.
Arnelo, Urban, Haas, Stephan L., Löhr, J. -Matthias, Martin, Lena, Rutkowski, Wiktor, Thorell, Anders, Valente, Roberto, Vujasinovic, Miroslav   +7 more
core   +1 more source

Adipokines in liver diseases # [PDF]

Hepatology, 2009
Abstract Adipokines are polypeptides secreted in the adipose tissue in a regulated manner. While some of these molecules are expressed only by adipocytes, resident and infiltrating macrophages and components of the vascular stroma markedly contribute to expression of other adipokines. As a result, adipose tissue inflammation is
MARRA, FABIO, BERTOLANI, CRISTIANA
openaire   +3 more sources

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Circulating prosaposin and ependymin-related protein 1 levels are correlated with insulin resistance in type 2 diabetic patients

Frontiers in Endocrinology
ObjectiveSkeletal muscle and adipose tissues secrete myokines and adipokines to regulate energy metabolism. Experimental evidence indicates that prosaposin (PSAP) and ependymin-related protein 1 (EPDR1) are involved in the regulation of thermogenesis and
Xin Ji, Xin Ji, Yajing Wang, Yajing Wang, Sijia Xu, Sijia Xu, Ling Cao, Ling Cao, Penghua Fang, Zhenwen Zhang, Zhenwen Zhang   +10 more
doaj   +1 more source

Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. [PDF]

, 2012
ObjectiveTo investigate whether leptin and adiponectin are associated with body fat composition in a South Asian population independent of metabolic variables.DesignCross-sectional study.Subjects150 South Asian men and women, between the ages of 45-79 ...
Budoff, MJ, Hernandez, A, Kanaya, AM, Mathur, D, Shah, A   +4 more
core