Results 81 to 90 of about 36,782 (313)

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source

Unravelling the “adipokine paradox”: When the classic proatherogenic adipokine leptin is deemed the beneficial one [PDF]

, 2015
Adipokines released by adipose tissue have been recognised as important players in the development of cardiovascular disease. Leptin is a well-studied adipokine with an important role in body metabolism and energy expenditure and leptin-deficiency or ...
Dimitris, Tousoulis, Antonopoulos, Alexios S., Antoniades, Charalambos   +3 more
core  

Association between TGFβ1 Levels in Cord Blood and Weight Progress in the First Year of Life

Biomedicines, 2023
Transforming growth factor beta-1 (TGFβ1) is an adipokine secreted from adipose tissue, placental tissue and immune cells with a role in cell proliferation, cell apoptosis and angiogenic proliferation.
Noura Kabbani, Holger Stepan, Matthias Blüher, Thomas Ebert, Ronny Baber, Mandy Vogel, Wieland Kiess, Michael Stumvoll, Jana Breitfeld, Ulrike Lössner, Anke Tönjes, Susanne Schrey-Petersen   +11 more
doaj   +1 more source

Obesity, adipokines and asthma [PDF]

Allergy, 2009
Background:  The prevalence of asthma and obesity is increasing concomitantly, but many aspects of this link are unclear. Our objective was to examine whether obesity is associated with asthma in three time points of life, and whether immunomodulatory adipokines, leptin and adiponectin are linked to overweight‐associated asthma.Methods:  We studied the
T, Jartti, L, Saarikoski, L, Jartti, I, Lisinen, A, Jula, R, Huupponen, J, Viikari, O T, Raitakari   +7 more
openaire   +2 more sources

Leptin May Promote Eosinophilic CRSwNP Progression by Enhancing Eosinophil Chemotaxis and Angiogenesis Under a Type 2 Inflammatory Milieu

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis with nasal polyp (CRSwNP) is a heterogeneous Type 2 inflammatory disease characterized by enhanced eosinophilic infiltration. Both innate and adaptive immunity are involved in the onset and progression of CRSwNP.
Yuki Sonoda, Yohei Sato, Yoshimasa Imoto, Mayumi Tamari, Shigeharu Fujieda   +4 more
wiley   +1 more source

Ixekizumab With Tirzepatide Achieved Greater Disease Control Than Ixekizumab Alone in Adults With Psoriatic Arthritis and Overweight or Obesity: Results From a Randomized Clinical Trial

Arthritis &Rheumatology, EarlyView.
Objective Overweight or obesity is prevalent in 72% to 82% of individuals with psoriatic arthritis (PsA). We assessed the efficacy and safety of ixekizumab (IXE) concomitantly administered with tirzepatide (TZP) compared with IXE alone in adult participants with active PsA and overweight with at least one weight‐related comorbidity or obesity.
Joseph F. Merola, Philip Mease, Alan Kivitz, Naveed Sattar, Laura C. Coates, Daniel Aletaha, Cynthia E. Kartman, Peter Fischer, Luna Sun, Píndaro Martínez‐Osuna, Andris Kronbergs, Purvi Prajapati, Anabela Cardoso, Mark C. Genovese, Alexis Ogdie   +14 more
wiley   +1 more source

Identification of adipokine clusters related to parameters of fat mass, insulin sensitivity and inflammation. [PDF]

, 2014
In obesity, elevated fat mass and ectopic fat accumulation are associated with changes in adipokine secretion, which may link obesity to inflammation and the development of insulin resistance.
Nora Klöting, Byung-Soo Youn, Markus Scholz, Anke Tönjes, Mathias Fasshauer (17104), Matthias Blüher, Gesine Flehmig (589105), Anke Tönjes (103703), Gesine Flehmig, Michael Stumvoll, Michael Stumvoll (103716), Byung-Soo Youn (280573), Matthias Blüher (103713), Mathias Fasshauer, Markus Scholz (157675), Nora Klöting (230996)   +15 more
core   +1 more source

Unveiling the perfect workout: exercise modalities and dosages to ameliorate adipokine dysregulation in individuals with overweight and obesity: a systematic review with pairwise, network, and dose–response meta-analyses

Frontiers in Nutrition
BackgroundObesity is commonly associated with dysregulation of adipokines, particularly characterized by elevated leptin levels and reduced adiponectin levels.
Hai Wang, Hao Wang, Enyan Zhan, Xiaodong Liu   +3 more
doaj   +1 more source

Adipokines in pregnancy

Reproductive success consists of a sequential events chronology, starting with the ovum fertilization, implantation of the embryo, placentation, and cellular processes like proliferation, apoptosis, angiogenesis, endocrinology, or metabolic changes, which taken together finally conduct the birth of healthy offspring.
Dawid, Monika, Pich, Karolina, Mlyczyńska, Ewa, Respekta-Długosz, Natalia, Wachowska, Dominika, Greggio, Aleksandra, Szkraba, Oliwia, Kurowska, Patrycja, Rak, Agnieszka   +8 more
openaire   +3 more sources

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source