Results 241 to 250 of about 76,948 (302)

Association between plasma glucose-dependent insulinotropic polypeptide and active adiponectin in normoglycemic women. [PDF]

open access: yesEndocr Connect
Salvatierra I   +6 more
europepmc   +1 more source

Is AMP‐activated protein kinase activation a central mechanism of cardio‐metabolic outcomes after metabolic and bariatric surgery?

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3480-3490, May 2026.
Abstract Metabolic and bariatric surgery (MBS) is the most effective treatment for severe obesity. It usually results in spectacular weight loss, associated with improvements of obesity‐associated comorbidities. The mechanisms underlying these benefits are not fully understood but could involve a postoperative activation of the enzyme 5′ AMP‐activated ...
Adrien Delcour, Nathalie Niederhoffer
wiley   +1 more source

Flexible dose of semaglutide reduces early discontinuation while maintaining comparable outcomes in obese patients: FLEX‐SEMA 2.4 mg, an Italian real‐world study

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3623-3631, May 2026.
Abstract Aims To evaluate real‐world clinical use of semaglutide in obese patients, focusing on titration, tolerability and short‐term efficacy. Materials and Methods This retrospective study included obese patients treated with the weekly injectable semaglutide.
Simone Pampanelli   +12 more
wiley   +1 more source

Causal role of genetically predicted impairment of branched‐chain amino acid catabolism on insulin secretion and insulin resistance in type 2 diabetes

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3849-3860, May 2026.
Abstract Background Elevated branched‐chain amino acids (BCAAs; leucine, valine, isoleucine) are linked to type 2 diabetes (T2D) risk, characterised by defective insulin secretion in pancreatic β‐cell and peripheral insulin resistance. Causative interaction between BCAA metabolism and these two diabetic pathogenesis remains unclear.
Xiangyu Zhou   +4 more
wiley   +1 more source

Weight Loss as a Determinant of Histological Improvement in Metabolic Dysfunction‐Associated Steatotic Liver Disease in People With Obesity. A Systematic Review and Network Meta‐Analysis of Randomised Clinical Trials

open access: yesDiabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4253-4260, May 2026.
ABSTRACT Background Metabolic dysfunction‐associated steatotic liver disease (MASLD) is closely linked to obesity and insulin resistance, and sustained weight loss is associated with histological improvement. Whether different obesity‐management modalities exert weight‐independent hepatic effects remains uncertain.
Matteo Monami   +11 more
wiley   +1 more source

Rural to Urban Migration Is Associated with Increased Leptin Resistance: The RODAM Study. [PDF]

open access: yesObes Facts
Kusi-Mensah YA   +9 more
europepmc   +1 more source

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