Results 41 to 50 of about 1,003 (148)

Disruption of Adipokinetic Hormone Mediated Energy Homeostasis Has Subtle Effects on Physiology, Behavior and Lipid Status During Aging in Drosophila

Frontiers in Physiology, 2018
The impact of disruption of adipokinetic hormone (AKH) signaling was studied during aging in Drosophila in a sexually dimorphic manner. A mutant (Akh1) producing a non-functional AKH peptide was compared with isogenized wild-type controls (w1118), and ...
Andrea Bednářová, Andrea Bednářová, Aleš Tomčala, Michaela Mochanová, Michaela Mochanová, Dalibor Kodrík, Dalibor Kodrík, Natraj Krishnan   +7 more
doaj   +1 more source

Mass Spectrometric Proof of Predicted Peptides: Novel Adipokinetic Hormones in Insects

Molecules, 2022
The importance of insects in our ecosystems is undeniable. The indiscriminate use of broad-spectrum insecticides is a factor in the decline in insect biomass.
Heather G. Marco, Simone König, Gerd Gäde   +2 more
doaj   +1 more source

Isolation and structure elucidation of a novel adipokinetic hormone (Lom‐AKH‐III) from the glandular lobes of the corpus cardiacum of the migratory locust, Locusta migratoria [PDF]

European Journal of Biochemistry, 1991
A new adipokinetic hormone (named Lom‐AKH‐III) was isolated from the glandular lobes of the corpora cardiaca of Locusta migratoria. At the N‐terminus it is blocked by a 5‐oxoproline (pyroglutamic acid) residue (< Glu). After enzymatic deblocking, the amino acid sequence of the N‐terminus was partly established by automatic Edman degradation to be ...
R C, Oudejans, F P, Kooiman, W, Heerma, C, Versluis, A J, Slotboom, M T, Beenakkers   +5 more
openaire   +2 more sources

Adaptation of the invasive pest Drosophila suzukii to a specialized nutritional niche

Insect Science, EarlyView.
Unlike most Drosophila larvae that feed on spoiled food, Drosophila suzukii larvae thrive on ripening fruits and consequently face a low‐protein, high‐carbohydrate nutritional challenge. Comparisons of growth among D. suzukii, D. biarmipes, and D. melanogaster larvae across diets with varying protein‐to‐carbohydrate ratios demonstrate that D.
Yan Hou, Ying Zhen
wiley   +1 more source

AKH-FOXO pathway regulates starvation-induced sleep loss through remodeling of the small ventral lateral neuron dorsal projections.

PLoS Genetics, 2020
Starvation caused by adverse feeding stresses or food shortages has been reported to result in sleep loss in animals. However, how the starvation signal interacts with the central nervous system is still unknown. Here, the adipokinetic hormone (AKH)-Fork
Qiankun He, Juan Du, Liya Wei, Zhangwu Zhao   +3 more
doaj   +1 more source

Trehalose and Glycogen Dynamics in Galleria mellonella Under Stress: Tissue‐Specific Insights

Entomological Research, Volume 56, Issue 7, July 2026.
ABSTRACT Insects employ flexible metabolic strategies to cope with acute environmental stress. This study investigates how different stressors, including physical, mechanical, and thermal, influence carbohydrate metabolism in Galleria mellonella larvae.
Tülay Turgut Genç, Serhat Kaya
wiley   +1 more source

Sulfakinin Signaling Sense Circulating Fructose and Suppresses Food Consumption via Insulin‐Like Peptide in Bactrocera Dorsalis

Advanced Science, Volume 13, Issue 29, 22 May 2026.
This study discovered a new pathway that tells fruit flies when to stop eating. It found that rising blood sugar (fructose) is detected by a sensor called GR43a. This triggers a chain reaction involving the satiety signal sulfakinin and its receptor, ultimately activating a final satiety signal, ILP5.
Hong‐Fei Li, Bao Dong, Zheng‐Lin Ren, Xue‐Guang Zhu, Quan Lei, Yoonseong Park, Jin‐Jun Wang, Hong‐Bo Jiang   +7 more
wiley   +1 more source

In Silico Screening for Pesticide Candidates against the Desert Locust Schistocerca gregaria

Life, 2022
Adipokinetic hormone (AKH) is one of the most important metabolic neuropeptides in insects, with actions similar to glucagon in vertebrates. AKH regulates carbohydrate and fat metabolism by mobilizing trehalose and diacylglycerol into circulation from ...
Graham E. Jackson, Gerd Gäde, Heather G. Marco   +2 more
doaj   +1 more source

Pss knockdown in the midgut causes growth retardation in Drosophila similar to that in human LMHD

Developmental Dynamics, Volume 255, Issue 5, Page 451-463, May 2026.
Abstract Background Phosphatidylserine synthase (PSS), localized in the mitochondrial membrane, synthesizes phosphatidylserine. In humans, mutations in Pss lead to Lenz–Majewski hyperostotic dwarfism, a disorder affecting growth and development. The effects of Pss mutations on the growth of Drosophila melanogaster are not fully known. Hence, this study
Kwan‐Young Kim, You‐Lim Hwang, Sunwoo Yeom, Seung‐Hae Kwon, Sang‐Hak Jeon   +4 more
wiley   +1 more source

Threonine sulfation: a rare post translational modification in insect adipokinetic hormones

Scientific Reports
Peptides of the adipokinetic hormone family are responsible for metabolic roles in insects, regulating release of energy metabolites from the fat body. We report on adipokinetic hormone octapeptide sequences bearing a rarely identified post-translational
Gerd Gäde, Simone König, Sameer S. Kulkarni, Richard J. Payne, Heather G. Marco   +4 more
doaj   +1 more source