Results 21 to 30 of about 13,270,977 (291)

Adipose differentiation-related protein regulates lipids and insulin in pancreatic islets

American Journal of Physiology-Endocrinology and Metabolism, 2010
The excess accumulation of lipids in islets is thought to contribute to the development of diabetes in obesity by impairing β-cell function. However, lipids also serve a nutrient function in islets, and fatty acids acutely increase insulin secretion. A better understanding of lipid metabolism in islets will shed light on complex effects of lipids on β ...
D M, Faleck, K, Ali, R, Roat, M J, Graham, R M, Crooke, R, Battisti, E, Garcia, R S, Ahima, Y, Imai   +8 more
openaire   +3 more sources

Structure of the Gene Encoding Mouse Adipose Differentiation-Related Protein (ADRP)

Genomics, 1993
Adipose differentiation-related protein (ADRP) is a novel 50-kDa membrane-associated protein whose message levels are induced rapidly and maximally after triggering adipocyte differentiation. The gene encoding mouse ADRP has been isolated and characterized from four overlapping lambda phage clones.
D P, Eisinger, G, Serrero
openaire   +2 more sources

Lnc13728 facilitates human mesenchymal stem cell adipogenic differentiation via positive regulation of ZBED3 and downregulation of the WNT/β-catenin pathway

Stem Cell Research & Therapy, 2021
Background Obesity has received increasing attention because of its widespread worldwide occurrence and many threats to health. Human adipose-derived mesenchymal stem cells (hADSCs) are a critical source of adipocytes.
Haoying Xu, Yanlei Yang, Linyuan Fan, Luchan Deng, Junfen Fan, Di Li, Hongling Li, Robert Chunhua Zhao   +7 more
doaj   +1 more source

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

eLife, 2021
Preadipocytes are crucial for healthy adipose tissue expansion. Preadipocyte differentiation is altered in obese individuals, which has been proposed to contribute to obesity-associated metabolic disturbances. Here, we aimed at identifying the pathogenic
Julia Sánchez-Ceinos, Rocío Guzmán-Ruiz, Oriol Alberto Rangel-Zúñiga, Jaime López-Alcalá, Elena Moreno-Caño, Mercedes Del Río-Moreno, Juan Luis Romero-Cabrera, Pablo Pérez-Martínez, Elsa Maymo-Masip, Joan Vendrell, Sonia Fernández-Veledo, José Manuel Fernández-Real, Jurga Laurencikiene, Mikael Rydén, Antonio Membrives, Raul M Luque, José López-Miranda, María M Malagón   +17 more
doaj   +1 more source

Induction of Adipose Differentiation Related Protein and Neutral Lipid Droplet Accumulation in Keratinocytes by Skin Irritants [PDF]

Journal of Investigative Dermatology, 2003
Keratinocytes play an important role in skin irritation. In an attempt to investigate mechanistic bases of human skin irritation response, we recently identified the upregulation by skin irritants of adipose differentiation related protein (ADRP) in reconstituted human epidermis.
E. Corsini, B. Viviani, O. Zancanella, L. Lucchi, F. Visioli, G. Serrero, S. Bartesaghi, C.L. Galli, M. Marinovich   +8 more
openaire   +2 more sources

Quantitative proteomics in resected renal cancer tissue for biomarker discovery and profiling [PDF]

, 2014
BACKGROUND: Proteomics-based approaches for biomarker discovery are promising strategies used in cancer research. We present state-of-art label-free quantitative proteomics method to assess proteome of renal cell carcinoma (RCC) compared with noncancer ...
J T-J Huang, Bray, S E, Fleming, S., Lamont, D J, D J Lamont, Zakikhani, P, P Zakikhani, M A V Mudaliar, Atrih, A, S Fleming, Zakikhani, P., Lamont, D. J., Barton, G.; id_orcid, G Nabi, G Barton, A Atrih, Bray, S. E., Barton, G, Huang, J. T.-J.; id_orcid, Mudaliar, M. A. V., Atrih, A., Fleming, S, Nabi, G, Nabi, G., Huang, J T-J, S E Bray, Mudaliar, M A V   +26 more
core   +1 more source

Effect of Adipose Differentiation-Related Protein (ADRP) on Glucose Uptake of Skeletal Muscle [PDF]

Korean Diabetes Journal, 2009
Background: Skeletal muscle is the most important tissue contributing to insulin resistance. Several studies have shown that accumulation of intramyocellular lipid is associated with the development of insulin resistance. Thus, proteins involved in lipid transport, storage and metabolism might also be involved in insulin action in skeletal muscle ...
Yun Hyi Ku, Min Kim, Sena Kim, Ho Seon Park, Han-Jong Kim, In-Kyu Lee, Dong Hoon Shin, Sung Soo Chung, Sang Gyu Park, Young Min Cho, Hong Kyu Lee, Kyong Soo Park   +11 more
openaire   +1 more source

Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]

, 2014
Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core   +1 more source

RAB37 Promotes Adipogenic Differentiation of hADSCs via the TIMP1/CD63/Integrin Signaling Pathway

Stem Cells International, 2021
The adipogenic differentiation ability of human adipose-derived mesenchymal stem cells (hADSCs) is critical for the construction of tissue engineering adipose, which shows promising applications in plastic surgery and regenerative medicine.
Haili Huang, Anran Li, Jin Li, Dan Sun, Ling Liang, Kunyan Pan, Chengzhang He, Peihua Zhang   +7 more
doaj   +1 more source

Evaluation of the relationship between GPR43 and adiposity in human

Nutrition & Metabolism, 2013
Background GPR43 is a G-protein-coupled receptor that participates in adipocyte differentiation in mice and is over-expressed in adipose tissue of obese mice. The aim of this study was to investigate the implication of GPR43 in adipogenesis in humans and
Dewulf Evelyne M, Ge Qian, Bindels Laure B, Sohet Florence M, Cani Patrice D, Brichard Sonia M, Delzenne Nathalie M   +6 more
doaj   +1 more source