Results 31 to 40 of about 13,270,977 (291)

Glucagon regulates intracellular distribution of adipose differentiation-related protein during triacylglycerol accumulation in the liver [PDF]

Journal of Lipid Research, 2010
Cellular lipid droplets (LD) are organelles involved in cellular lipid metabolism. When liver cellular components were fractionated using sucrose density gradient centrifugation, adipose differentiation-related protein (ADRP) was distributed in both the top and bottom fractions, which correspond to the LD and membranous fractions, respectively, in the ...
Katsuhiko Takahashi, Naoko Sasabe, Kumiko Ohshima, Keiko Kitazato, Rina Kato, Yutaka Masuda, Mika Tsurumaki, Takashi Obama, Shin-ichi Okudaira, Junken Aoki, Hiroyuki Arai, Tomohiro Yamaguchi, Hiroyuki Itabe   +12 more
openaire   +3 more sources

Metformin prevents hepatic steatosis by regulating the expression of adipose differentiation-related protein

International Journal of Molecular Medicine, 2013
Non-alcoholic fatty liver disease (NAFLD) is a common liver disease, characterized by the excess accumulation of lipids in the liver. It has been demonstrated that the dysregulation of lipid droplet (LD)-associated proteins may be involved in the development of NAFLD.
LIU, FANG, WANG, CHAO, ZHANG, LIJUN, XU, YUQIAO, JANG, LINA, GU, YU, CAO, XIANGMEI, ZHAO, XIN, YE, JING, LI, QING   +9 more
openaire   +3 more sources

Hulless barley polyphenol extract inhibits adipogenesis in 3T3-L1 cells and obesity related-enzymes

Frontiers in Nutrition, 2022
Obesity is characterized by excessive lipid accumulation, hypertrophy, and hyperplasia of adipose cells. Hulless barley (Hordeum vulgare L. var. nudum Hook. f.) is the principal crop grown in the Qinghai-Tibet plateau.
Xianfeng Deng, Bi Chen, Qin Luo, Xingru Zao, Haizhe Liu, Yongqiang Li   +5 more
doaj   +1 more source

Synergistic Effects of a Mixture of Glycosaminoglycans to Inhibit Adipogenesis and Enhance Chondrocyte Features in Multipotent Cells

Cellular Physiology and Biochemistry, 2015
Background/Aims: Multipotent mesenchymal stem cells affect homeostasis of adipose and joint tissues. Factors influencing their differentiation fate are of interest for both obesity and joint problems.
Petar D. Petrov, Nuria Granados, Carles Chetrit, Daniel Martínez-Puig, Andreu Palou, M. Luisa Bonet   +5 more
doaj   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

Deficiency of Adipose Differentiation-Related Protein Impairs Foam Cell Formation and Protects Against Atherosclerosis [PDF]

Circulation Research, 2008
Foam cells are a hallmark of atherosclerosis. However, it is unclear whether foam cell formation per se protects against atherosclerosis or fuels it. In this study, we investigated the role of adipose differentiation-related protein (ADFP), a major lipid droplet protein (LDP), in the regulation of foam cell formation and atherosclerosis ...
Antoni, Paul, Benny Hung-Junn, Chang, Lan, Li, Vijay K, Yechoor, Lawrence, Chan   +4 more
openaire   +2 more sources

Hypoxia Alters the Expression of Dipeptidyl Peptidase 4 and Induces Developmental Remodeling of Human Preadipocytes

Journal of Diabetes Research, 2016
Dipeptidyl peptidase 4 (DPP4), a transmembrane protein, has been identified in human adipose tissue and is considered to be associated with obesity-related type 2 diabetes. Since adipose tissue is relatively hypoxic in obese participants, we investigated
Helena H. Chowdhury, Jelena Velebit, Nataša Radić, Vito Frančič, Marko Kreft, Robert Zorec   +5 more
doaj   +1 more source

Bioactivity in Whey Proteins Influencing Energy Balance [PDF]

, 2012
Peer-reviewedObesity develops due to energy (food) intake exceeding energy expenditure. Nutrients that reduce the positive energy balance are thus being considered as therapies to combat obesity.
Nilaweera, Kanishka, Cotter, Paul D., Korpela, Riitta, McAllan, Liam, Roche, Helen M.   +4 more
core   +1 more source

Autophagy involved in lipopolysaccharide-induced foam cell formation is mediated by adipose differentiation-related protein [PDF]

Lipids in Health and Disease, 2014
Autophagy is an essential process for breaking down macromolecules and aged/damaged cellular organelles to maintain cellular energy balance and cellular nutritional status. The idea that autophagy regulates lipid metabolism is an emerging concept with important implications for atherosclerosis.
Feng, Xuyang, Yuan, Yuan, Wang, Chao, Feng, Jun, Yuan, Zuyi, Zhang, Xiumin, Sui, Wen, Hu, Peizhen, Zheng, Pengfei, Ye, Jing   +9 more
openaire   +2 more sources

Effect of Insulin-Regulated FOXC2 Expression in Adipocyte Differentiation and Insulin Resistance

Diabetes, Metabolic Syndrome and Obesity, 2020
Xuxiang Zhang,1 Yuming Wang,2 Fan Zuo,1 Yandan Su,3 Hua Liu,3 Bin Wu,1 Xin Nian1 1Department of Endocrinology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People’s Republic of China; 2Department of Clinical Laboratory,
Zhang X, Wang Y, Zuo F, Su Y, Liu H, Wu B, Nian X   +6 more
doaj