Results 111 to 120 of about 63,479 (255)

Evaluating the Endocrine‐Disrupting and Oxidative Stress Potential of a 50‐Component Human‐Relevant Complex Chemical Mixture Using In Vitro Tests

Journal of Applied Toxicology, EarlyView.
ABSTRACT Humans are chronically exposed to mixtures of environmental contaminants. Exposure to endocrine‐disrupting chemicals (EDCs) contributes to increased health impairment observed globally. This study aimed to evaluate the endocrine‐disruptive and oxidative stress potential of a human‐relevant, complex chemical mixture in vitro.
Josefin Engelhardt, Nathalie Struwe, Annika Jansson, Vesna Munic Kos, Maria Larsson, Jana M. Weiss   +5 more
wiley   +1 more source

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Physiologically Based Pharmacokinetic Modeling of Oxcarbazepine to Characterize Its Disposition in Children with Obesity

The Journal of Clinical Pharmacology, EarlyView.
Abstract Oxcarbazepine (OXC) is a second‐generation antiseizure medication, effective through its active metabolite, 10‐mono‐hydroxy derivative (MHD). OXC is used as adjunctive therapy for focal‐onset and primary generalized tonic–clonic seizures, with recommended dosing based on age and body weight.
Patricia D. Maglalang, Jaydeep Sinha, Victόria Etges Helfer, Andrea Edginton, Kanecia Zimmerman, Chi Dang Hornik, William J. Muller, Mobeen Rathore, Daniel K. Benjamin Jr., Jia‐Yuh Chen, Ravinder Anand, Daniel Gonzalez, the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee   +12 more
wiley   +1 more source

Brown adipose tissue

, 2015
Anna Maffione, Arlene Campos, Mostafa Elfeky   +2 more
openaire   +2 more sources

Acyl-CoA Binding Protein in White and Brown Adipose Tissue Is Dispensable for Systemic Energy Metabolism in Mice. [PDF]

Acta Physiol (Oxf)
Nørremark MF, Petersen R, Ruppert PMM, Jul ES, Doktor TK, Nielsen R, Kappel JF, Larsen S, Kornfeld JW, Mandrup S, Andresen BS, Havelund J, Neess D, Færgeman NJ.   +13 more
europepmc   +1 more source

Wild‐Derived House Mice (Mus musculus) Are Able to Cope With a Constant Light Environment

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Exposure to altered nighttime lighting conditions has become common in today's modern world. Light at night disrupts circadian processes that govern feeding patterns, sleep/wake cycles, and metabolic homoeostasis, increasing the risk of developing pathologies associated with cardiometabolic disease. Yet, the underlying mechanism(s) responsible
Kevin Pham, KayLene Y. H. Yamada, Emma M. Rhodes, Agata. M. Rudolf, Wendy R. Hood   +4 more
wiley   +1 more source

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis-Insights into Canonical and Non-Canonical Regulatory Pathways. [PDF]

Int J Mol Sci
Simka-Lampa K.
europepmc   +1 more source

Biomarkers for the estimation of isoproterenol‐induced myocardial infarction: A review of key parameters

Journal of Intelligent Medicine, EarlyView.
Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran, Tarique Mahmood, Farogh Ahsan, Shahzadi Bano, Vaseem Ahamad Ansari, Mohd Adnan   +5 more
wiley   +1 more source

Vitamin A Derivatives and Adipose Tissue Differentiation: Molecular Pathways Driving Browning and Anti-Obesity Effects. [PDF]

Curr Obes Rep
Bilikozen Aygun B, Basturk B, Ayaz A.
europepmc   +1 more source

Comparative effects of superheated steam and hot air roasting on the in vitro phospholipase A2 inhibitory activity and polyphenol composition of cocoa beans

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Cocoa, derived from Theobroma cacao, is a popular food ingredient used to produce chocolate. Cocoa is rich in polyphenols and human and laboratory model studies have indicated that cocoa and chocolate can mitigate chronic inflammatory conditions.
Sawali Navare, Bethany H. Lam, Misha T. Kwasniewski, Ramaswamy Anantheswaran, Joshua D. Lambert   +4 more
wiley   +1 more source