Results 161 to 170 of about 83,245 (269)

The Therapeutic Potential of Theobromine in Obesity: A Comprehensive Review. [PDF]

Nutr Rev
Tuğal Aslan D, Göktaş Z.
europepmc   +1 more source

Drug‐Based Lifespan Extension in Mice Strongly Affects Lipids Across Six Organs

Aging Cell, EarlyView.
Using six interventions that have previously shown to differentially increase lifespan in male and female mice, we here show significant metabolic changes across organs, sex and metabolic pathways. Specifically, lipid responses were prominent across organs, but also in a sexually dimorphic manner.
Sara Greenfield, Nathaniel C. Stevens, Lauren Bishop, Zachary Rabow, Daniela C. Soto, Abdali Omar Abdullah, Richard A. Miller, Oliver Fiehn   +7 more
wiley   +1 more source

A comparative analysis of the impact of repeated administration of flavan 3-ol on brown, subcutaneous, and visceral adipose tissue. [PDF]

Open Med (Wars)
Osakabe N, Nakamura H, Yoshida Y, Katsuragawa S, Iida N, Fujii Y, Jacob UM, Fritsch T, Abdelhameed A, Calabrese V.   +9 more
europepmc   +1 more source

The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders

Aging Cell, EarlyView.
Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim, Hye Sun Go, Eun Jae Jeon, Thi Quynh Trang Nguyen, Da Yeon Kim, Hansung Park, Hyo‐Ji Eom, Sung Young Kim, Sang Chul Park, Kyung A Cho   +9 more
wiley   +1 more source

Epigenetic and pharmacological control of pigmentation via Bromodomain Protein 9 (BRD9)

Pigment Cell &Melanoma Research, Volume 36, Issue 1, Page 19-32, January 2023., 2023
Abstract Lineage‐specific differentiation programs are activated by epigenetic changes in chromatin structure. Melanin‐producing melanocytes maintain a gene expression program ensuring appropriate enzymatic conversion of metabolites into the pigment, melanin, and transfer to surrounding cells.
Tupa Basuroy, Megan Dreier, Caitlin Baum, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Ivana L. de la Serna   +6 more
wiley   +1 more source

Sex and Depot Specific Adipocyte Proteome Profiling In Vivo via Intracellular Proximity Labeling. [PDF]

Compr Physiol
Simonian TL, Meyer AS, Guo J, Sha J, Wohlschlegel JA, Droujinine IA, Perrimon N, McMahon AP.   +7 more
europepmc   +1 more source

Harnessing Immune Rejuvenation: Advances in Overcoming T Cell Senescence and Exhaustion in Cancer Immunotherapy

Aging Cell, EarlyView.
Cancer can weaken the immune system by pushing T cells into exhaustion or permanent aging (senescence), making treatments less effective. This review explores groundbreaking therapies—like immune boosters, cell engineering, and senolytics—that aim to rejuvenate T cells, helping the body fight cancer more effectively and for longer.
Tesfahun Dessale Admasu, John S. Yu
wiley   +1 more source

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

White adipose tissue uptake on 18F FDG PET/CT: A case report

Radiology Case Reports
Three distinct types of adipose tissue have been characterized: brown, white, and beige. Brown adipose tissue (BAT) is typically found in specific regions including the anterior cervical, supraclavicular, axillary, and paravertebral areas.
Maria Andrea Parra Corral, MD, Jesus R. Diaz, MD   +1 more
doaj  

Deubiquitinating enzyme USP2 regulates brown adipose tissue thermogenesis via controlling EBF2 stabilization. [PDF]

Mol Metab
Xu Y, Chen Y, Bai N, Su Y, Ye Y, Zhang R, Yang Y, Liu C, Hu C, Pan J.   +9 more
europepmc   +1 more source