Small Science, EarlyView.Current weight‐loss medications inevitably cause adverse effects such as depression or muscle loss. The developed GIP/ICG@P/R8 NPs specifically promoted energy expenditure by inducing browning, lipolysis and apoptosis of WAT in vitro and in vivo. The results showed a 9.23% weight reduction after 14 days, enhanced insulin sensitivity, improved fatty ...
Ting Xie +11 more
wiley +1 more source
Adipose Tissue, at the Core of the Action of Incretin and Glucagon-Based Anti-Obesity Drugs. [PDF]
Curr Obes RepVillarroya F, Peyrou M, Giralt M.
europepmc +1 more source
Functional Ecology, EarlyView.Read the free Plain Language Summary for this article on the Journal blog. Abstract Phenotypic plasticity is a strategy by which animals alter behaviour, morphology and/or physiology in response to cues of current conditions to cope with environmental heterogeneity.
Lauren Petrullo +3 more
wiley +1 more source
Seasonal body mass dynamics mediate life‐history trade‐offs in a hibernating mammal
Journal of Animal Ecology, EarlyView.We tested a suite of ecological hypotheses to explain variation in seasonal body mass dynamics of a fat‐storing mammalian hibernator. We further demonstrated that pre‐hibernation mass gain in ground squirrels mediates an annual allocation trade‐off between current and future reproduction as the squirrels forage and rear young under predation risk ...
Austin Z. T. Allison +4 more
wiley +1 more source
Mediastinal Hibernoma on Fluorine-18 Fluorodeoxyglucose (18F-FDG) Positron-Emission Tomography/Computed Tomography (PET/CT): A Case Report and Literature Review. [PDF]
CureusGutierrez Albenda D +4 more
europepmc +1 more source
Aging Cell, EarlyView.Using male vascular endothelial cell–specific Nampt knockout and naturally aged mice, we identified endothelial NAD+ deficiency as a central driver of age‐related angiogenic failure, impaired subcutaneous adipogenesis, and cardiometabolic dysfunction.
Shotaro Kosugi +18 more
wiley +1 more source
Mechanisms of Variation in Abdominal Adipose Color Among Male Kazakh Horses Through Non-Coding RNA Sequencing. [PDF]
Biology (Basel)Zhou Y +6 more
europepmc +1 more source
TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation
Aging Cell, EarlyView.TRPM7 deficiency reduces lactate production in endothelial cells and downregulates both p300 expression and nuclear translocation. These changes collectively lead to decreased H3K18 lactylation levels. Consequently, this downregulates genes vital for vascular homeostasis while upregulating genes associated with aging and vascular remodeling (including ...
Yue Wang +9 more
wiley +1 more source
Loss of histone methyltransferase Smyd3 triggers WAT browning and adaptive thermogenesis via enhancing PPARγ expression in a H4K20me3-dependent manner. [PDF]
J Transl MedShu M +7 more
europepmc +1 more source
Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys
Aging Cell, EarlyView.Here we show shared and depot‐specific adaptations to life‐long CR in subcutaneous and visceral adipose depots from advanced‐age male rhesus monkeys. Transcriptomics reveal differences between the depots, as well as shared and distinct CR‐responsive pathways.
Josef P. Clark +6 more
wiley +1 more source