The kallikrein–kinin pathway as a mechanism for auto-control of brown adipose tissue activity
Nature Communications, 2020 Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides ...
Marion Peyrou +10 more
doaj +1 more source
METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice
Nature Communications, 2020 Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that
Yuqin Wang +8 more
semanticscholar +1 more source
Presence of the brown fat-specific mitochondrial uncoupling protein and iodothyronine 5'-deiodinase activity in subcutaneous adipose tissue of neonatal lambs [PDF]
, 1993 Subcutaneous adipose tissue of neonatal lambs has been examined for the presence of markers diagnostic of thermogenic brown fat. Uncoupling protein, uncoupling protein mRNA, and iodothyronine 5'-deiodinase activity were each detected in subcutaneous ...
Arthur, John R. +4 more
core +1 more source
Regulatory microRNAs in Brown, Brite and White Adipose Tissue
Cells, 2020 MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation.
S. Gharanei +6 more
semanticscholar +1 more source
miR-34a-/- mice are susceptible to diet-induced obesity [PDF]
, 2016 Objective: MicroRNA (miR)−34a regulates inflammatory pathways, and increased transcripts have been observed in serum and subcutaneous adipose of subjects who have obesity and type 2 diabetes.
Baker, Andrew H. +7 more
core +1 more source
Cold-activated brown adipose tissue in healthy men.
New England Journal of Medicine, 2009 BACKGROUND Studies in animals indicate that brown adipose tissue is important in the regulation of body weight, and it is possible that individual variation in adaptive thermogenesis can be attributed to variations in the amount or activity of brown ...
W. D. van Marken Lichtenbelt +7 more
semanticscholar +1 more source
Pre- and postnatal adipose tissue development in farm animals: from stem cells to adipocyte physiology [PDF]
, 2016 To view supplementary material for this article, please visit http://dx.doi.org/10.1017/S1751731116000872Both white and brown adipose tissues are recognized to be differently involved in energy metabolism and are also able to secrete a variety of ...
Bonnet, Muriel +3 more
core +3 more sources
Di-san junyi daxue xuebao, 2019 Objective To study the changes in the metabolic activity of brown adipose tissues in a mouse model of progeria using Cerenkov luminescence imaging. Methods 18F-FDG PET/CT imaging and Cerenkov luminescence imaging were used to dynamically monitor the ...
WANG Zhengjie +4 more
doaj +1 more source
Human brown adipose tissue: Classical brown rather than brite/beige?
Experimental Physiology, 2020 What is the topic of this review? It has been suggested that human brown adipose tissue (BAT) is more similar to the brite/beige adipose tissue of mice than to classical BAT of mice.
B. Cannon +4 more
semanticscholar +1 more source
Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]
, 2015 BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L. +9 more
core +3 more sources