Results 41 to 50 of about 347,415 (326)
Reduced maximum capacity of glycolysis in brown adipose tissue of genetically obese, diabetic (db/db) mice and its restoration following treatment with a thermogenic β-adrenoceptor agonist [PDF]
, 1984 The maximal activities of the key glycolytic enzymes hexokinase and 6-phosphofructokinase, were reduced in brown adipose tissue in db/db mice compared to their lean littermates.
Cawthorne, M.A. +3 more
core +1 more source
Epicardial adipose tissue in contemporary cardiology
Nature Reviews Cardiology, 2022 Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and unobstructed proximity to the heart and has a transcriptome and secretome very ...
G. Iacobellis
semanticscholar +1 more source
Brown vs white adipocytes: The PPARγ coregulator story [PDF]
, 2010 The development of adipose tissue is a process which involves the concerted cooperation of numerous transcription factors together with their coactivators and corepressors.
Kalkhoven, Eric, Koppen, Arjen
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Bioengineering beige adipose tissue therapeutics
Frontiers in Endocrinology, 2015 Unlocking the therapeutic potential of brown/beige adipose tissue requires technological advancements that enable the controlled expansion of this uniquely thermogenic tissue.
Kevin eTharp, Andreas eStahl
doaj +1 more source
Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]
PLoS ONE, 2013 Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura +6 more
doaj +1 more source
Functional brown adipose tissue in healthy adults.
New England Journal of Medicine, 2009 Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects.
K. Virtanen +10 more
semanticscholar +1 more source
Intravitreally injected anti-VEGF antibody reduces brown fat in neonatal mice [PDF]
, 2015 Anti-vascular endothelial growth factor (VEGF) agents are the mainstay treatment for various angiogenesis-related retinal diseases. Currently, bevacizumab, a recombinant humanized anti-VEGF antibody, is trailed in retinopathy of prematurity, a ...
A Hellstrom +40 more
core +10 more sources
Adipocyte lipid synthesis coupled to neuronal control of thermogenic programming [PDF]
, 2017 BACKGROUND: The de novo biosynthesis of fatty acids (DNL) through fatty acid synthase (FASN) in adipocytes is exquisitely regulated by nutrients, hormones, fasting, and obesity in mice and humans. However, the functions of DNL in adipocyte biology and in
Czech, Michael P +11 more
core +4 more sources
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
Casein Kinase 2—A Kinase that Inhibits Brown Fat Formation [PDF]
, 2015 In adipose tissue, there is a delicate balance between storing and expending energy. In this issue, Shinoda et al. (2015) use phosphoproteomics to identify casein kinase 2 (CK2) as a suppressor of brown adipocyte formation, providing insights into how ...
Enerbäck, Sven
core +1 more source