Results 131 to 140 of about 220,180 (319)

Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1

Molecular Metabolism, 2018
Objective: Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed ‘browning’), has great therapeutic potential to treat obesity and its ...
Dianxin Liu, Ryan P. Ceddia, Sheila Collins   +2 more
doaj   +1 more source

Sirtuins 1–7 expression in human adipose-derived stem cells from subcutaneous and visceral fat depots: influence of obesity and hypoxia [PDF]

, 2016
The sirtuin family comprises seven NAD+-dependent deacetylases which control the overall health of organisms through the regulation of pleiotropic metabolic pathways.
Di Rocco, Giuliana, Mariani, Stefania, Petrangeli, Elisa, Russo, Matteo A., Salvatori, Luisa, Toietta, Gabriele   +5 more
core   +1 more source

Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang, Yuan Fang, Lingli Jin, Dongyang Liu, Yicheng Liu, Ruijia Zheng, Liyun Yong, Xin Wu, Longliang Qiao, Meiyan Wang, Fengfeng Cai   +10 more
wiley   +1 more source

Development of a targeted and controlled nanoparticle delivery system for FoxO1 inhibitors [PDF]

, 2020
Background: Poly (lactic-co-glycolic acid) (PLGA) and polyethylene glycol (PEG) are polymers approved by the United States’ Food and Drug Administration.
Cheng, Zhiyong, Ferrer Vega, Andrea, Imondo, Michael, Lewinski, Nastassja, McInnes, Bridget T., Mulyar, Andriy   +5 more
core   +1 more source

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans [PDF]

, 2015
Background Genomewide association studies can be used to identify disease-relevant genomic regions, but interpretation of the data is challenging. The FTO region harbors the strongest genetic association with obesity, yet the mechanistic basis of this ...
Abdennur, Nezar Alexander, Beaudry, Jacqueline L., Claussnitzer, Melina, Dankel, Simon N., Drucker, Daniel J., Glunk, Viktoria, Haugen, Christine, Hauner, Hans, Hsu, Yi-Hsiang, Hui, Chi-Chung, Kellis, Manolis, Kim, Kyoung-Han, Liu, Jannel, Mellgren, Gunnar, Meuleman, Wouter, Puviindran, Vijitha, Quon, Gerald, Sousa, Isabel S., Svensson, Per-Arne   +18 more
core   +1 more source

Targeting the CMKLR1‐Mediated Signaling Rebalances Immunometabolism State in Middle‐Age Testicular Macrophages

Advanced Science, EarlyView.
In middle age, testicular CMKLR1⁺ macrophages exhibited a pro‐inflammatory immunometabolic profile, mediated by adipose signals associated with high BMI. However, inhibition of CMKLR1 signaling, either through Cmklr1 genetic ablation or treatment with a CMKLR1 antagonist peptide, can reverse this phenotype.
Zhendong Zhu, Feifei Du, Yang Liu, Jinchunzi Yang, Lei Ge, Tianxia Xiao, Mengxia Li, Jie Chen, Jia Tang, Yali Yang, Jian V. Zhang   +10 more
wiley   +1 more source

PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning

Nature Communications
PINK1/Parkin-mediated ubiquitin-dependent mitophagy is a critical negative regulatory machinery for browning in the inguinal white adipose tissue (iWAT). However, the precise regulatory mechanism underlying PINK1/Parkin-mediated mitophagy during browning
Xuetao Ji, Xu Zhang, Tong Zhang, Yao Xue, Mengping He, Chaopu Li, Yun Huang, Haoyu Wang, Jing Ju, Li’e Cai, Yuzhu Wang, Ning Wang, Lijuan Fan, Hui Tong, Heng Fan, Qinsheng Chen, Qinwei Lu, Cong Li, Huiru Tang, Yongsheng Chang, Xingxing Kong, Hanming Shen, Aihua Gu, Hui Liang, Hongwen Zhou, Qian Wang, John Zhong Li   +26 more
doaj   +1 more source

Adipositas & Bewegung / Obesity & Physical Activity

Deutsche Zeitschrift für Sportmedizin, 2016
Most of white and brown adipocytes, in spite of their different functions storing energy and thermogenesisare contained together in subcutaneous and visceral depots.
Cinti S
doaj   +1 more source

A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction

Advanced Science, EarlyView.
Obesity involves chronic inflammation and mitochondrial dysfunction. This study identifies cytochrome P450 2E1 (CYP2E1) as a novel inflammatory target in adipose tissue. Its activity increases in obese mice and correlates with inflammation and mitochondrial impairment.
Jinhuan Qiu, Liyuan Gao, Liyang Wang, Xueke Wang, Lin Jia, Mengyan Deng, Liming Tang, Qiang Wen, Na Gao, Haiwei Xu, Hailing Qiao   +10 more
wiley   +1 more source

A Simplified Three‐Tailed N‐Alkyl Phosphoramidate Lipid Platform Enables Inguinal Adipose‐Accumulated mRNA Delivery for Anti‐Obesity Therapy

Advanced Science, EarlyView.
This study develops an mRNA therapy encoding a long‐acting GLP‐1/FGF21 fusion protein. A three‐tailed ionizable lipid engineered three‐component lipid nanoparticle delivers the mRNA to inguinal adipose tissue. In obese mice, this targeted, dual‐hormone treatment potently reduces body weight, fat mass, presenting a localized strategy for metabolic ...
Bin Ma, Yunxuan Liu, Huijuan Zhang, Yian Fang, Yizhe Xue, Junsheng Xue, Ziqiong Jiang, Tianyan Zhou, Yanyun Hao, Fei Xie, Lei Miao   +10 more
wiley   +1 more source