Results 121 to 130 of about 14,567 (295)

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

Cdkn2a deficiency promotes adipose tissue browning

, 2018
Objectives: Genome-wide association studies have reported that DNA polymorphisms at the CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) risk.
Fajas, Lluis, Annicotte, Jean-Sébastien, Xavier Gromada, Amélie Bonnefond, Durand, E., Salas, Elisabet, Oger, Frédérik, Dani, C., Bonnefond, Amélie, Annicotte, J.S., Yao, Xi, Rabearivelo, Iandry, Rabhi, Nabil, Yao, X., Lluis Fajas, Caron, Emilie, Oger, F., Emilie Caron, Dani, Christian, Hannou, S.A., Hannou, Sarah Anissa, Nabil Rabhi, Carney, C., Caron, E., Elisabet Salas, Christian Dani, Lopez-Mejia, I.C., Gromada, X., Rabearivelo, I., Emmanuelle Durand, Sarah Anissa Hannou, Isabel C. Lopez-Mejia, Lopez-Mejia, Isabel, C, Iandry Rabearivelo, Jean-Sébastien Annicotte, Bonnefond, A., Frédérik Oger, Froguel, P., Durand, Emmanuelle, Gromada, Xavier, Xi Yao, Fajas, L., Rabhi, N., Charlène Carney, Philippe Froguel, Froguel, Philippe, Carney, Charlène, Salas, E.   +47 more
core   +1 more source

Sleep deprivation aggravates hepatocytes steatosis and insulin resistance by regulating exosomal microRNAs

Interdisciplinary Medicine, EarlyView.
Sleep deprivation accelerates the progression of MASLD and IR by up‐regulating the expression of miR‐3572‐5p and down‐regulating the expression of miR‐183‐5p in circulating exosomes, thereby inhibiting fatty acid β‐oxidation and disrupting insulin signaling pathways. Abstract Sleep deprivation (SD) threatens human health and increases the prevalence of 
Xinxin Xu, Lulu Li, Ying Cao, Ying Wang, Chao Yang, Alexander Nikolaevich Orekhov, Yuanfeng Lu, Houbin Chu, Chuanrong Zhao, Guixue Wang, Guohua Song   +10 more
wiley   +1 more source

The DMHGABA Neurons Play a Crucial Role in the Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Advanced Science
The browning of white adipose tissue (WAT) can convert energy‐storing WAT into energy‐dissipating beige adipose tissue to combat obesity and metabolic dysfunction. Cold exposure is a WAT browning‐inducing condition in mice.
Zhijie Su, Yujia Hou, Bingwei Wang, Qian Zhou, Wen Yang, Bingbing Guo, Chenyu Zhang, Miao Zhao, Xiaoning Yang, Jiarui Liu, Xiangyang Xie, Lihua Qin, Weiguang Zhang, Wei L. Shen, Ruimao Zheng   +14 more
doaj   +1 more source

A Latent Profile Analysis of Body Image and Disordered Eating Attitudes and Behaviors in Adolescent Boys

Journal of Adolescence, EarlyView.
ABSTRACT Introduction Adolescence is a risk period for body dissatisfaction which can contribute to eating disorder development. Given sex or gender differences in body image and disordered eating, it is critical to examine body image and eating concerns in adolescent boys and whether mindfulness is associated with body image and eating attitudes and ...
Madeline R. Olwert, Shelley R. Hart, Delwin Carter, Natalie R. Stromberg   +3 more
wiley   +1 more source

Adipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes

Nanomaterials
Obesity is a global epidemic which induces a multitude of metabolic disorders. Browning of white adipose tissue (WAT) has emerged as a promising therapeutic strategy for promoting weight loss and improving associated metabolic syndromes in people with ...
Yuanyuan Zhang, Xiaojiao Zeng, Fan Wu, Xiaopeng Yang, Tingting Che, Yin Zheng, Jie Li, Yufei Zhang, Xinge Zhang, Zhongming Wu   +9 more
doaj   +1 more source

Adipose Tissue Browning Through Stress and Transfection

Obesity and its related diseases are rapidly increasing in prevalence and pose a costly challenge to American healthcare systems. At the core of the metabolic dysfunction associated with obesity is adipose tissue, which stores excess energy stores in the
Gunawan, Amanda Lestari
core  

New Approach Methodologies (NAMs) in Alternative Methods: A Comparative Cytotoxicity Analysis of Nanostructured Hydroxyapatite in Adipose Stem Cells Spheroids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro, Rosângela Mayer Gonçalves, Marcelle Gomes Pegurier, Isabelle Amorim, Alexandre Malta Rossi, Leandra Santos Baptista   +5 more
wiley   +1 more source

Prolactin and Triiodothyronine Modulate Seasonal Variation in Brown Adipose Tissue in Djungarian Hamsters

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT Seasonal photoperiodic cycles regulate energy rheostasis in many animals. Brown adipose tissue (BAT) and the liver are key metabolic organs that show remarkable plasticity in response to photoperiodic conditions. Prolactin (PRL) and thyroid hormones are endocrine signals that transmit neural‐derived photoperiodic time measurement encoding to ...
Sayantan Sur, Grace Payling, Calum Stewart, Avalene Tan, Caitlin Diggle, Tyler J. Stevenson   +5 more
wiley   +1 more source

What Fat Is That? Scanning Perirenal Fat: A Survey of Australasian Sonographers

Journal of Medical Radiation Sciences, EarlyView.
What fat is that? Ultrasound measurement of perirenal adipose tissue and CVD. Results of a survey of Australasian sonographers 2024. ABSTRACT Introduction Ultrasound measures of perirenal adipose tissue (PRAT) have emerged as potentially efficient, cost‐effective, and accessible methods for assessing cardiovascular disease (CVD) risk.
Victoria Baumann, Richard Banati, Jillian Clarke   +2 more
wiley   +1 more source