Results 101 to 110 of about 14,567 (295)

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source

Systems-Genetics-Based Inference of a Core Regulatory Network Underlying White Fat Browning

Cell Reports, 2019
Summary: Recruitment of brite/beige cells, known as browning of white adipose tissue (WAT), is an efficient way to turn an energy-storing organ into an energy-dissipating one and may therefore be of therapeutic value in combating obesity.
Yongguo Li, Petra C. Schwalie, Andrea Bast-Habersbrunner, Sabine Mocek, Julie Russeil, Tobias Fromme, Bart Deplancke, Martin Klingenspor   +7 more
doaj   +1 more source

Exercise-Mediated Browning of White Adipose Tissue: Its Significance, Mechanism and Effectiveness

, 2021
As a metabolic organ, adipose tissue plays an important role in regulating metabolism. In adults, most adipose tissue is white adipose tissue (WAT), and excessive expansion of WAT will lead to obesity.
Liang Guo, Jie-Ying Zhu, Wang-Jing Mu, Min Chen   +3 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Cardiac natriuretic peptides promote adipose ‘browning’ through mTOR complex-1

Molecular Metabolism, 2018
Objective: Activation of thermogenesis in brown adipose tissue (BAT) and the ability to increase uncoupling protein 1 (UCP1) levels and mitochondrial biogenesis in white fat (termed ‘browning’), has great therapeutic potential to treat obesity and its ...
Dianxin Liu, Ryan P. Ceddia, Sheila Collins   +2 more
doaj   +1 more source

Nutritional, Functional, and Anti‐Hypercholesterolemic Properties of Sourdough Breads From Unripe Plantain, Tiger Nut, and Fenugreek Flours

Food Chemistry International, EarlyView.
Composite sourdough breads were developed from blends of unripe plantain, tiger nut, and fenugreek flours. Optimized formulations improved pasting stability and enhanced texture, producing softer more elastic crumbs. The enriched breads contained higher dietary fiber and bioactive compounds, and significantly reduced serum cholesterol markers ...
Mary T. Ademosun, Olufunmilayo S. Omoba, Ganiyu Oboh, Adedamola I. Akinyede, Rukayat O. Awolola   +4 more
wiley   +1 more source

PNPLA7 mediates Parkin-mitochondrial recruitment in adipose tissue for mitophagy and inhibits browning

Nature Communications
PINK1/Parkin-mediated ubiquitin-dependent mitophagy is a critical negative regulatory machinery for browning in the inguinal white adipose tissue (iWAT). However, the precise regulatory mechanism underlying PINK1/Parkin-mediated mitophagy during browning
Xuetao Ji, Xu Zhang, Tong Zhang, Yao Xue, Mengping He, Chaopu Li, Yun Huang, Haoyu Wang, Jing Ju, Li’e Cai, Yuzhu Wang, Ning Wang, Lijuan Fan, Hui Tong, Heng Fan, Qinsheng Chen, Qinwei Lu, Cong Li, Huiru Tang, Yongsheng Chang, Xingxing Kong, Hanming Shen, Aihua Gu, Hui Liang, Hongwen Zhou, Qian Wang, John Zhong Li   +26 more
doaj   +1 more source

Adipositas & Bewegung / Obesity & Physical Activity

Deutsche Zeitschrift für Sportmedizin, 2016
Most of white and brown adipocytes, in spite of their different functions storing energy and thermogenesisare contained together in subcutaneous and visceral depots.
Cinti S
doaj   +1 more source

Proso Millet (Panicum miliaceum): Nutritional Composition, Functional Attributes, and Health Implications

Future Postharvest and Food, EarlyView.
A nutrient‐dense grain, proso millet is well‐known for its high protein content and vital amino acids. It is high in fiber, vitamins, and minerals and has many health advantages, including promoting heart health, enhancing digestion, and helping with weight management.
Sangeeta Yadav, Pratiksha Singh, Mazia Ahmed, Pinki Saini   +3 more
wiley   +1 more source

Diffuse optical spectroscopy and imaging to detect and quantify adipose tissue browning

, 2017
Adipose (fat) tissue is a complex metabolic organ that is highly active and essential. In contrast to white adipose tissue (WAT), brown adipose tissue (BAT) is deemed metabolically beneficial because of its ability to burn calories through heat ...
Balasundaram, G., Balasundaram, G, Olivio, M., Sriram, S., Ong, Wee Kiat, Olivo, M, Wong, C.L, Dinish, U. S., Sugii, S, Sugii, S., Ong, W.K, Dinish, U.S, Balasundaram, Ghayathri, Wong, C. L., Dinish, U. S, Sugii, Shigeki, Sriram, Sandhya, Olivo, Malini, Sriram, S, Wong, Chi Lok   +19 more
core   +1 more source