Results 81 to 90 of about 1,840,318 (295)

From muscle fibres to muscle gears: how dynamic fascicle orientation and shape change impact skeletal muscle function

Biological Reviews, EarlyView.
ABSTRACT Skeletal muscle architectural design strongly affects force‐generating capacity and excursion range, and its functional importance to animal and human movement is well founded. Traditionally, this ‘structure–function relation’ has been inferred from architecture measurements with muscles at rest (from anatomical dissections or medical imaging ...
Matheus D. Pinto, James M. Wakeling, Javier A. Almonacid, Anthony J. Blazevich   +3 more
wiley   +1 more source

Brown adipose tissue in humans

Annals of Medicine, 2015
In spite of the long history of evidence for brown adipose tissue (BAT) in adult humans (1), the evidence of its functionality was missing.
openaire   +4 more sources

Carbonic anhydrase 2 mediates anti-obesity effects of black tea as thermogenic activator

Food Science and Human Wellness
Obesity is a metabolic disorder due to over-accumulation of adipose tissue and ultimately becomes a “disease”. Brown adipose tissue (BAT) thermogenesis and white adipose tissue (WAT) browning emerge as a potential strategy of anti-obesity by dissipating ...
Peng Ma, Jie Xiao, Biyu Hou, Ping He, Xinyu Yang, Yisa Wang, Zijing Wang, Tianshu Xu, Xiuying Yang, Xuan Zhu, Shasha Xiang, Song Li, Guanhua Du, Jian Ying, Guifen Qiang   +14 more
doaj   +1 more source

Adipose Angiogenesis Models in Animals and Methodology

, 2013
Adipose tissue angiogenesis plays a crucial role in the organism as blood vessels are required to supply nutrients and oxygen to the adipose tissue and to remove metabolic waste products.
Honek, J, Lim, S, Sharon Lim, Yihai Cao, Cao, Y, Jennifer Honek   +5 more
core   +1 more source

Increased Insulin Action, Glucose Metabolism and Muscle Function in Supervillin‐Knockout and Supervillin‐Mutant Mice

Cytoskeleton, EarlyView.
ABSTRACT We here describe mouse models with complementary homozygous Svil mutations. In skeletal muscle, Svil‐Mut mice express the Svil‐encoded N‐terminus fused to the βgal‐neo gene‐trap tag and lack the highly conserved archvillin C‐terminus; Svil‐KO mice lack expression of all known Svil‐encoded proteins; and Svil‐LoxP mice contain loxP sites for ...
Tara C. Smith, Lauren A. Tauer, Randall H. Friedline, Xiaodi Hu, Duy Tran, Yangyi E. Luo, Nacima Hadjout‐Rabi, Elisabeth R. Barton, Jason K. Kim, Elizabeth J. Luna   +9 more
wiley   +1 more source

Intermittent Fasting‐Induced Orm2 Promotes Adipose Browning via the GP130/IL23R‐p38 Cascade

Advanced Science
Intermittent fasting (IF) plays a critical role in mitigating obesity, yet the precise biological mechanisms require further elucidation. Here Orosomucoid 2 (Orm2) is identified as an IF‐induced hepatokine that stimulates adipose browning.
Xuejuan Zhu, Xinran Wang, Jingang Wang, Lei Du, Zhen‐Ning Zhang, Donglei Zhou, Junfeng Han, Bing Luan   +7 more
doaj   +1 more source

When LXA4 meets white fat: browning via the miR-133a-3p/SIRT1 pathway in mouse models

Adipocyte
Given the established positive role of Lipoxin A4 (LXA4) in adipose browning at the cellular level, this study investigated its possible effect on white fat browning and the underlying molecular mechanisms.
Dan Yu, Yuan Ruan, Yisu Wang, Xiaopei Chen, Dan Wang, Tianfeng Wu   +5 more
doaj   +1 more source

Endurance training promotes the browning of WAT by enhancing the NPFF pathway in the hypothalamus in rats with type 2 diabetes [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Type 2 diabetes (T2D) represents a complex and multifactorial disorder, and efforts to discover its treatment are necessary. Browning of white adipose tissue (WAT) as a therapeutic target for diabetes seems to be induced by exercise through
Syiedeh Maryam Mousavi, Fatemeh Zahra Gorji, Ziya Fallahmohammadi, Khadijeh Nasiri, Abolfazl Akbari   +4 more
doaj   +1 more source

Two key temporally distinguishable molecular and cellular components of white adipose tissue browning during cold acclimation

, 2015
Conversion of white into brown adipose tissue may have important implications in obesity resistance and treatment. Several browning agents or conditions ignite thermogenesis in white adipose tissue (WAT).
Golic, Igor, Korać, Bato, Korac, Aleksandra, Markelic, Milica, Stančić, Ana, Janković, Aleksandra, Otašević, Vesna, Buzadžić, Biljana J., Buzadzic, Biljana, Korać, Bato M.   +9 more
core   +1 more source

Role of SoxE transcription factors in development and disease

Developmental Dynamics, EarlyView.
Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley   +1 more source