Results 81 to 90 of about 261,601 (310)

Ectopic cardiovascular fat in middle-aged men: effects of race/ethnicity, overall and central adiposity. The ERA JUMP study. [PDF]

, 2015
Background/objectivesHigher volumes of ectopic cardiovascular fat (ECF) are associated with greater risk of coronary heart disease (CHD). Identifying factors that are associated with ECF volumes may lead to new preventive efforts to reduce risk of CHD ...
Barinas-Mitchell, E, Budoff, M, Edmundowicz, D, El Khoudary, SR, El-Saed, A, ERA JUMP Study Group, Evans, RW, Fujiyoshi, A, Hisamatsu, T, Kadowaki, S, Kuller, LH, Masaki, K, Miura, K, Ohkubo, T, Sekikawa, A, Shin, C, Ueshima, H, Willcox, BJ   +17 more
core   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

A better performing algorithm for identification of implausible growth data from longitudinal pediatric medical records

Scientific Reports
Tracking trajectories of body size in children provides insight into chronic disease risk. One measure of pediatric body size is body mass index (BMI), a function of height and weight. Errors in measuring height or weight may lead to incorrect assessment
Kylie K. Harrall, Sarah M. Bird, Keith E. Muller, Lauren A. Vanderlinden, Maya E. Payton, Anna Bellatorre, Dana Dabelea, Deborah H. Glueck   +7 more
doaj   +1 more source

The Role of Heart Rate on the Associations Between Body Composition and Heart Rate Variability in Children With Overweight/Obesity: The ActiveBrains Project

Frontiers in Physiology, 2019
BackgroundHeart rate variability (HRV) is negatively associated with body mass index and adiposity in several populations. However, less information is available about this association in children with overweight and obesity, especially severe/morbid ...
Abel Plaza-Florido, Jairo H. Migueles, Jose Mora-Gonzalez, Pablo Molina-Garcia, Pablo Molina-Garcia, Maria Rodriguez-Ayllon, Cristina Cadenas-Sanchez, Irene Esteban-Cornejo, Irene Esteban-Cornejo, Socorro Navarrete, Rosa Maria Lozano, Nathalie Michels, Jerzy Sacha, Jerzy Sacha, Francisco B. Ortega, Francisco B. Ortega   +15 more
doaj   +1 more source

Changing guards: time to move beyond Body Mass Index for population monitoring of excess adiposity [PDF]

, 2015
With the obesity epidemic, and the effects of aging populations, human phenotypes have changed over two generations, possibly more dramatically than in other species previously.
Combet, Emilie, Lean, Michael E. J., Peeters, Anna, Tanamas, Stephanie K., Vlassopoulos, Antonios, Zimmet, Paul Z   +5 more
core   +1 more source

Perivascular Adipose Tissue [PDF]

, 2019
Key Concepts:- While traditionally viewed as little more than a simple lipid reserve, perivascular adipose tissue (PVAT) boasts an extensive biological arsenal which when mobilized can modulate vascular function.- PVAT dysfunction in disease is associated with alteration to its secretory profile which can create a contractile and pro-inflammatory ...
Javed, Saad, Alakrawi, Mariam, Greenstein, Adam S.   +2 more
openaire   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

Body mass composition of ballet dancers and elite female aesthetic sport athletes from Cuba.

Revista Brasileira de Cineantropometria e Desempenho Humano, 2011
The level of scenic beauty of ballet dancer’s figure is signified for the reason of possessing morpho-functional characteristics valid only within the artistic cannon.
Hamlet Betancout León, Oscar Salinas Flores, Julieta Aréchiga Viramontes   +2 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source