Results 111 to 120 of about 770,531 (353)

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

String adjunct grammars: I. Local and distributed adjunction

open access: yesInformation and Control, 1972
In this paper [and in Joshi et al. (1972) which is a sequel to this paper] a new style of formal grammar called String Adjunct Grammars (AG) has been studied. The rules in an AG have a character essentially different from the “rewrite rule” in a Phrase Structure Grammar (PSG).
Aravind K. Joshi   +2 more
openaire   +1 more source

New antituberculosis drugs, regimens, and adjunct therapies: needs, advances, and future prospects.

open access: yesLancet. Infectious Diseases (Print), 2014
About 1·3 million people died of tuberculosis in 2012, despite availability of effective drug treatment. Barriers to improvements in outcomes include long treatment duration (resulting in poor patient adherence and loss of patients to follow-up), complex
Alimuddin Zumla   +9 more
semanticscholar   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Modifying (the grammar of) adjuncts : an introduction [PDF]

open access: yes, 2003
One aspect of the progress being made is that the focus of attention has widened. Adverbials, though still the heart of the matter, now form part of a much larger set of constituent types subsumed under the general syntactic label of adjunct; while ...
Fabricius-Hansen, Cathrine   +2 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Alternative Learning Environments in Arkansas [PDF]

open access: yes, 2006
One intervention that has been shown to be successful in helping students who have not done well in traditional school settings is alternative learning environments (ALE), or alternative schools (Lehr, Lanners, & Lange, 2003). The U.S.
McKenzie, Sarah C., Ritter, Gary W.
core   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Investigating the incorporation of milled rice in brewing non-alcoholic beer to enhance sensory quality

open access: yesInternational Journal of Food Properties
The influence of substituting barley malt with milled rice on the sensory and chemical characteristics of nonalcoholic beers (NAB) was investigated. Physicochemical and volatile analyses were conducted on the NABs.
Christian Schubert   +3 more
doaj   +1 more source

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