Results 11 to 20 of about 809,966 (374)

12-Hydroxyeicosapentaenoic acid inhibits foam cell formation and ameliorates high-fat diet-induced pathology of atherosclerosis in mice

Scientific Reports, 2021
Atherosclerosis is a chronic inflammatory disease associated with macrophage aggregate and transformation into foam cells. In this study, we sought to investigate the impact of dietary intake of ω3 fatty acid on the development of atherosclerosis, and ...
Takahiro Nagatake, Yuki Shibata, Sakiko Morimoto, Eri Node, Kento Sawane, So-ichiro Hirata, Jun Adachi, Yuichi Abe, Junko Isoyama, Azusa Saika, Koji Hosomi, Takeshi Tomonaga, Jun Kunisawa   +12 more
doaj   +1 more source

IL-33 Is Essential for Adjuvant Effect of Hydroxypropyl-β-Cyclodexrin on the Protective Intranasal Influenza Vaccination

Frontiers in Immunology, 2020
Vaccine adjuvants are traditionally used to augment and modulate the immunogenicity of vaccines, although in many cases it is unclear which specific molecules contribute to their stimulatory activity.
Shingo Kobari, Shingo Kobari, Takato Kusakabe, Takato Kusakabe, Takato Kusakabe, Masatoshi Momota, Masatoshi Momota, Takayuki Shibahara, Takayuki Shibahara, Takayuki Shibahara, Tomoya Hayashi, Tomoya Hayashi, Tomoya Hayashi, Koji Ozasa, Koji Ozasa, Hideaki Morita, Kenji Matsumoto, Hirohisa Saito, Shuichi Ito, Etsushi Kuroda, Etsushi Kuroda, Etsushi Kuroda, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +26 more
doaj   +1 more source

Adjuvant Pembrolizumab after Nephrectomy in Renal-Cell Carcinoma.

New England Journal of Medicine, 2021
BACKGROUND Patients with renal-cell carcinoma who undergo nephrectomy have no options for adjuvant therapy to reduce the risk of recurrence that have high levels of supporting evidence. METHODS In a double-blind, phase 3 trial, we randomly assigned, in
T. Choueiri, P. Tomczak, S. Park, B. Venugopal, T. Ferguson, Yen‐Hwa Chang, J. Hajek, S. Symeonides, Jae Lyun Lee, N. Sarwar, A. Thiery-Vuillemin, M. Gross-Goupil, M. Mahave, N. Haas, P. Sawrycki, H. Gurney, C. Chevreau, B. Melichar, Evgeniy Kopyltsov, A. Alva, J. Burke, G. Doshi, D. Topart, S. Oudard, H. Hammers, H. Kitamura, J. Bedke, R. Perini, Pingye Zhang, K. Imai, Jaqueline Willemann-Rogerio, D. Quinn, T. Powles   +32 more
semanticscholar   +1 more source

Bile acids induce IL-1α and drive NLRP3 inflammasome-independent production of IL-1β in murine dendritic cells

Frontiers in Immunology, 2023
Bile acids are amphipathic molecules that are synthesized from cholesterol in the liver and facilitate intestinal absorption of lipids and nutrients. They are released into the small intestine upon ingestion of a meal where intestinal bacteria can modify
Ewa Oleszycka, Ewa Oleszycka, Eoin C. O’Brien, Michael Freeley, Ed C. Lavelle, Aideen Long   +5 more
doaj   +1 more source

Response to neoadjuvant chemotherapy in breast cancer: do microRNAs matter?

Discover Oncology, 2022
Background Conventionally, breast cancer (BC) prognosis and prediction of response to therapy are based on TNM staging, histological and molecular subtype, as well as genetic alterations.
Dinara Ryspayeva, Volodymyr Halytskiy, Nazarii Kobyliak, Iryna Dosenko, Artem Fedosov, Mariia Inomistova, Tetyana Drevytska, Vitalyi Gurianov, Oksana Sulaieva   +8 more
doaj   +1 more source

SARS-CoV-2 spike-ferritin-nanoparticle adjuvanted with ALFQ induces long-lived plasma cells and cross-neutralizing antibodies

npj Vaccines, 2023
This study demonstrates the impact of adjuvant on the development of T follicular helper (Tfh) and B cells, and their influence on antibody responses in mice vaccinated with SARS-CoV-2-spike-ferritin-nanoparticle (SpFN) adjuvanted with either Army ...
Shikha Shrivastava, Joshua M. Carmen, Zhongyan Lu, Shraddha Basu, Rajeshwer S. Sankhala, Wei-Hung Chen, Phuong Nguyen, William C. Chang, Jocelyn King, Courtney Corbitt, Sandra Mayer, Jessica S. Bolton, Alexander Anderson, Isabella Swafford, Guillermo D. Terriquez, Hung V. Trinh, Jiae Kim, Ousman Jobe, Dominic Paquin-Proulx, Gary, R. Matyas, Gregory D. Gromowski, Jeffrey R. Currier, Elke Bergmann-Leitner, Kayvon Modjarrad, Nelson L. Michael, M. Gordon Joyce, Allison M. W. Malloy, Mangala Rao   +27 more
doaj   +1 more source

S-540956, a CpG Oligonucleotide Annealed to a Complementary Strand With an Amphiphilic Chain Unit, Acts as a Potent Cancer Vaccine Adjuvant by Targeting Draining Lymph Nodes

Frontiers in Immunology, 2021
Robust induction of cancer-antigen-specific CD8+ T cells is essential for the success of cancer peptide vaccines, which are composed of a peptide derived from a cancer-specific antigen and an immune-potentiating adjuvant, such as a Toll-like receptor ...
Takayuki Nakagawa, Tetsuya Tanino, Motoyasu Onishi, Soichi Tofukuji, Takayuki Kanazawa, Yukichi Ishioka, Takeshi Itoh, Akira Kugimiya, Kazufumi Katayama, Takuya Yamamoto, Morio Nagira, Ken J. Ishii, Ken J. Ishii, Ken J. Ishii   +13 more
doaj   +1 more source

Functional changes in cytotoxic CD8+ T-cell cross-reactivity against the SARS-CoV-2 Omicron variant after mRNA vaccination

Frontiers in Immunology, 2023
Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells in vaccinees longitudinally.
Takuto Nogimori, Takuto Nogimori, Koichiro Suzuki, Yuji Masuta, Yuji Masuta, Ayaka Washizaki, Ayaka Washizaki, Mika Yagoto, Mami Ikeda, Yuki Katayama, Hidenori Kanda, Minoru Takada, Shohei Minami, Takeshi Kobayashi, Shokichi Takahama, Shokichi Takahama, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Yasuo Yoshioka, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto, Takuya Yamamoto   +24 more
doaj   +1 more source

Polarised superlocalization in magnetic nanoparticle hyperthermia [PDF]

J. Phys. D 55 (2022) 205001, 2021
Magnetic hyperthermia is an adjuvant therapy for cancer where injected magnetic nanoparticles are used to transfer energy from the time-dependent applied magnetic field into the surrounding medium. Its main importance is to be able to increase the temperature of the human body locally.
arxiv   +1 more source

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

New England Journal of Medicine, 2005
BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial
R. Stupp, Warren P. Mason, M. J. van den Bent, M. Weller, B. Fisher, M. Taphoorn, K. Bélanger, A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, Robert C. Janzer, Samuel K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. Cairncross, E. Eisenhauer, René O. Mirimanoff   +18 more
semanticscholar   +1 more source