Results 41 to 50 of about 1,198,663 (392)

Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2−, Node-Positive, High-Risk, Early Breast Cancer (monarchE)

Journal of Clinical Oncology, 2020
PURPOSE Many patients with HR+, HER2− early breast cancer (EBC) will not experience recurrence or have distant recurrence with currently available standard therapies.
S. Johnston, N. Harbeck, R. Hegg, M. Toi, Miguel Martín, Z. Shao, Q. Zhang, Jorge Luis Martinez Rodriguez, M. Campone, E. Hamilton, J. Sohn, V. Guarneri, M. Okada, F. Boyle, P. Neven, J. Cortés, J. Huober, A. Wardley, S. Tolaney, I. Çiçin, I. Smith, Martin Frenzel, D. Headley, Ran Wei, B. San Antonio, M. Hulstijn, J. Cox, J. O’Shaughnessy, P. Rastogi   +28 more
semanticscholar   +1 more source

DAMP-Inducing Adjuvant and PAMP Adjuvants Parallelly Enhance Protective Type-2 and Type-1 Immune Responses to Influenza Split Vaccination

Frontiers in Immunology, 2018
Recently, it was reported that 2-hydroxypropyl-β-cyclodextrin (HP-β-CyD), a common pharmaceutical additive, can act as a vaccine adjuvant to enhance protective type-2 immunogenicity to co-administered seasonal influenza split vaccine by inducing host ...
Tomoya Hayashi, Tomoya Hayashi, Masatoshi Momota, Masatoshi Momota, Etsushi Kuroda, Etsushi Kuroda, Takato Kusakabe, Takato Kusakabe, Shingo Kobari, Kotaro Makisaka, Yoshitaka Ohno, Yoshitaka Ohno, Yusuke Suzuki, Fumika Nakagawa, Michelle S. J. Lee, Cevayir Coban, Risako Onodera, Taishi Higashi, Keiichi Motoyama, Ken J. Ishii, Ken J. Ishii, Hidetoshi Arima, Hidetoshi Arima   +22 more
doaj   +1 more source

Molecular Classification of the PORTEC-3 Trial for High-Risk Endometrial Cancer: Impact on Prognosis and Benefit From Adjuvant Therapy

Journal of Clinical Oncology, 2020
PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of combined adjuvant chemotherapy and radiotherapy (CTRT) versus radiotherapy alone (RT) for ...
A. Léon-Castillo, S. D. de Boer, M. Powell, L. Mileshkin, H. Mackay, A. Leary, H. Nijman, N. Singh, P. Pollock, P. Bessette, A. Fyles, C. Haie-meder, V. Smit, R. Edmondson, H. Putter, H. Kitchener, E. Crosbie, M. de Bruyn, R. Nout, N. Horeweg, C. Creutzberg, T. Bosse   +21 more
semanticscholar   +1 more source

17(S),18(R)‐epoxyeicosatetraenoic acid generated by cytochrome P450 BM‐3 from Bacillus megaterium inhibits the development of contact hypersensitivity via G‐protein‐coupled receptor 40‐mediated neutrophil suppression

FASEB BioAdvances, 2020
Dietary intake of ω3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid is beneficial for health control. We recently identified 17,18‐epoxyeicosatetraenoic acid (17,18‐EpETE) as a lipid metabolite endogenously generated ...
Azusa Saika, Takahiro Nagatake, Shigenobu Kishino, Si‐Bum Park, Tetsuya Honda, Naomi Matsumoto, Michiko Shimojou, Sakiko Morimoto, Prabha Tiwari, Eri Node, So‐ichiro Hirata, Koji Hosomi, Kenji Kabashima, Jun Ogawa, Jun Kunisawa   +14 more
doaj   +1 more source

Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.

New England Journal of Medicine, 2004
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the efficacy of this combination in patients with metastatic colorectal cancer.
T. André, C. Boni, L. Mounedji-Boudiaf, M. Navarro, J. Tabernero, T. Hickish, C. Topham, M. Zaninelli, P. Clingan, J. Bridgewater, I. Tabah-Fisch, A. de Gramont   +11 more
semanticscholar   +1 more source

SARS-CoV-2 ferritin nanoparticle vaccine induces robust innate immune activity driving polyfunctional spike-specific T cell responses

npj Vaccines, 2021
The emergence of variants of concern, some with reduced susceptibility to COVID-19 vaccines underscores consideration for the understanding of vaccine design that optimizes induction of effective cellular and humoral immune responses.
Joshua M. Carmen, Shikha Shrivastava, Zhongyan Lu, Alexander Anderson, Elaine B. Morrison, Rajeshwer S. Sankhala, Wei-Hung Chen, William C. Chang, Jessica S. Bolton, Gary R. Matyas, Nelson L. Michael, M. Gordon Joyce, Kayvon Modjarrad, Jeffrey R. Currier, Elke Bergmann-Leitner, Allison M. W. Malloy, Mangala Rao   +16 more
doaj   +1 more source

Diabetes alone should not be a reason for withholding adjuvant chemotherapy for stage III colon cancer [PDF]

, 2011
Background: With increasing prevalence of diabetes mellitus and colon cancer, the number of patients suffering from both diseases is growing, and physicians are being faced with complicated treatment decisions.
Dercksen, Wouter M.W., Extermann, Martine, Haak, Harm R., Janssen-Heijnen, Maryska L.G., van de Schans, Saskia A.M., van Waalwijk, Maren A.   +5 more
core   +2 more sources

Adjuvant Chemotherapy Guided by a 21‐Gene Expression Assay in Breast Cancer

New England Journal of Medicine, 2018
BACKGROUND The recurrence score based on the 21‐gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it is low; however, there is uncertainty about the benefit of chemotherapy
J. Sparano, R. Gray, D. Makower, K. Pritchard, K. Albain, D. Hayes, C. Geyer, E. Dees, M. Goetz, J. Olson, T. Lively, S. Badve, T. Saphner, L. Wagner, T. Whelan, M. Ellis, S. Paik, W. Wood, P. Ravdin, M. Keane, H. G. Gomez Moreno, P. Reddy, T. Goggins, I. Mayer, A. Brufsky, D. Toppmeyer, V. Kaklamani, J. Berenberg, J. Abrams, G. Sledge   +29 more
semanticscholar   +1 more source

Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning

Frontiers in Bioscience-Landmark, 2023
Background: Clostridium perfringens and Shiga toxin (Stx)-producing Escherichia coli (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of C.
Koji Hosomi, Atsushi Shimoyama, Atsushi Hinenoya, Noritoshi Hatanaka, Takafumi Noguchi, Hirotaka Ebina, Yoko Tojima, Mari Furuta, Masuo Kondoh, Hiroshi Kiyono, Shinji Yamasaki, Koichi Fukase, Jun Kunisawa   +12 more
doaj   +1 more source

Adjuvant Migraine Medications in the Treatment of Sudden Sensorineural Hearing Loss. [PDF]

, 2021
Objectives/hypothesisTo examine the hearing outcomes of patients with sudden sensorineural hearing loss (SSNHL) treated with oral and intratympanic (IT) steroid only or a combination of steroid and migraine treatment.
Abouzari, Mehdi, Chua, Janice T, Djalilian, Hamid R, Goshtasbi, Khodayar, Lin, Harrison W, Saber, Tina, Sarna, Brooke, Tan, Donald   +7 more
core   +1 more source