Results 41 to 50 of about 809,966 (374)
A Retrospective Analysis using Deep-Learning Models for Prediction of Survival Outcome and Benefit of Adjuvant Chemotherapy in Stage II/III Colorectal Cancer [PDF]
arXiv, 2021 Most early-stage colorectal cancer (CRC) patients can be cured by surgery alone, and only certain high-risk early-stage CRC patients benefit from adjuvant chemotherapies. However, very few validated biomarkers are available to accurately predict survival benefit from postoperative chemotherapy.
arxiv
Adjuvant Chemotherapy Guided by a 21‐Gene Expression Assay in Breast Cancer
New England Journal of Medicine, 2018 BACKGROUND The recurrence score based on the 21‐gene breast cancer assay predicts chemotherapy benefit if it is high and a low risk of recurrence in the absence of chemotherapy if it is low; however, there is uncertainty about the benefit of chemotherapy
J. Sparano +29 more
semanticscholar +1 more source
Endotoxin-Free Stx2B-C-CPE Vaccine and Its Optimized Adjuvant Regimen for Preventing Food Poisoning
Frontiers in Bioscience-Landmark, 2023 Background: Clostridium perfringens and Shiga toxin (Stx)-producing Escherichia coli (STEC) are common causes of food poisoning. We previously demonstrated the efficacy of Stx2B-C-CPE, a fusion protein of the C-terminal region of C.
Koji Hosomi +12 more
doaj +1 more source
Adjuvant Nivolumab versus Ipilimumab in Resected Stage III or IV Melanoma
New England Journal of Medicine, 2017 BACKGROUND Nivolumab and ipilimumab are immune checkpoint inhibitors that have been approved for the treatment of advanced melanoma. In the United States, ipilimumab has also been approved as adjuvant therapy for melanoma on the basis of recurrence‐free ...
J. Weber +33 more
semanticscholar +1 more source
Microorganisms, 2020 Effective and safe vaccine adjuvants are needed to appropriately augment mucosal vaccine effects. Our previous study demonstrated that lipopolysaccharide (LPS) from Peyer’s patch resident Alcaligenes stimulated dendritic cells to promote the production ...
Ken Yoshii +10 more
doaj +1 more source
Shaping Modern Vaccines: Adjuvant Systems Using MicroCrystalline Tyrosine (MCT®)
Frontiers in Immunology, 2020 The concept of adjuvants or adjuvant systems, used in vaccines, exploit evolutionary relationships associated with how the immune system may initially respond to a foreign antigen or pathogen, thus mimicking natural exposure.
Matthew D. Heath +14 more
doaj +1 more source
Local vaccination and systemic tumor suppression via irradiation and manganese adjuvant in mice [PDF]
arXiv, 2021 Presently 4T-1 luc cells were irradiated with proton under ultra-high dose rate FLASH or with gamma-ray with conventional dose rate, and then subcutaneous vaccination with or without Mn immuno-enhancing adjuvant into the mice for three times. One week later, we injected untreated 4T-1 luc cells on the other side of the vaccinated mice, and found that ...
arxiv
Adjuvant Capecitabine for Breast Cancer after Preoperative Chemotherapy
New England Journal of Medicine, 2017 BACKGROUND Patients who have residual invasive carcinoma after the receipt of neoadjuvant chemotherapy for human epidermal growth factor receptor 2 (HER2)‐negative breast cancer have poor prognoses.
N. Masuda +20 more
semanticscholar +1 more source
Alum Activates the Bovine NLRP3 Inflammasome
Frontiers in Immunology, 2017 There has been a move away from vaccines composed of whole or inactivated antigens toward subunit-based vaccines, which although safe, provide less immunological protection.
Ciaran Harte +8 more
doaj +1 more source
Nature Reviews Immunology, 2018 Besides cholesterol lowering, statins boost antigen presentation and adaptive immune responses, suggesting new uses as adjuvants for cancer immunotherapy.
openaire +2 more sources