Results 51 to 60 of about 809,966 (374)
Improving trial generalizability using observational studies [PDF]
, 2020 Complementary features of randomized controlled trials (RCTs) and observational studies (OSs) can be used jointly to estimate the average treatment effect of a target population. We propose a calibration weighting estimator that enforces the covariate balance between the RCT and OS, therefore improving the trial-based estimator's generalizability ...
arxiv +1 more source
HPB, 2006 Exocrine pancreatic cancer (pancreatic ductal adenocarcinoma) is one of the leading causes of cancer deaths in the western world, accounting for 5% of all cancer-related deaths. Only a small percentage of patients with pancreatic cancer are able to undergo potentially curative resection, even in specialized centres, and prognosis remains poor after ...
John P. Neoptolemos +2 more
openaire +3 more sources
Mathematical modelling of adjuvant-enhanced active ingredient leaf uptake of pesticides [PDF]
arXiv, 2022 The global importance of effective and affordable pesticides to optimise crop yield and to support health of our growing population cannot be understated. But to develop new products or refine existing ones in response to climate and environmental changes is both time-intensive and expensive which is why the agrochemical industry is increasingly ...
arxiv
Deutsches Ärzteblatt international, 2011 We thank the authors for their excellent review article. However, it is only of limited value in terms of an oncologically correct approach for specialist physicians in private practice. The authors describe in their article that after magnetic resonance tomography-aided planning, a primary R0 situation can mostly be achieved and reconstruction can be ...
Rudert, Maximilian +2 more
openaire +3 more sources
Vaccines, 2021 Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last decade. Although current therapies for the management of OUD can be effective, they have limitations.
Essie Komla +8 more
doaj +1 more source
Drug Discovery Today: Technologies, 2020 Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless.
Garcia-Vello, Pilar +4 more
openaire +6 more sources
Adjuvant Dabrafenib plus Trametinib in Stage III BRAF‐Mutated Melanoma
New England Journal of Medicine, 2017 BACKGROUND Combination therapy with the BRAF inhibitor dabrafenib plus the MEK inhibitor trametinib improved survival in patients with advanced melanoma with BRAF V600 mutations.
G. Long +22 more
semanticscholar +1 more source
Dendritic cell proliferation by primary cilium in atopic dermatitis
Frontiers in Molecular Biosciences, 2023 Introduction: Atopic dermatitis (AD) is a common allergic eczema that affects up to 10% of adults in developed countries. Immune cells in the epidermis, namely, Langerhans cells (LCs), contribute to the pathogenesis of AD, although their exact role(s) in
Manami Toriyama +19 more
doaj +1 more source
Adjuvant Treatment of Melanoma [PDF]
ISRN Dermatology, 2011 Melanomas represent 4% of all malignant tumors of the skin, yet account for 80% of deaths from skin cancer.While in the early stages patients can be successfully treated with surgical resection, metastatic melanoma prognosis is dismal. Several oncogenes have been identified in melanoma as BRAF, NRAS, c-Kit, and GNA11 GNAQ, each capable of activating ...
Moreno Nogueira, J A +2 more
openaire +6 more sources
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source