Results 211 to 220 of about 15,663 (264)
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Immunology of Vaccine Adjuvants
2009In recent times vaccine adjuvants, or immunopotentiators, received abundant attention in the media as critical ingredients of current and future vaccines. Indeed, vaccine adjuvants are recognized to make the difference between competing vaccines based on identical antigens.
Ribeiro, C.M.S., Schijns, V.E.J.C.
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Glucans as Immunological Adjuvants
1995β-1,3-Linked glucopyranose (β-glucan), a major structural component of yeast, fungi, and algae [1], has a wide range of biological activities. Systemic administration of β-glucan (1) provides nonspecific resistance in experimental animals against a variety of pathogenic challenges [2–7]; (2) prolongs the survival time of tumor-bearing animals [8,9]; (3)
N. Mohagheghpour +11 more
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Glycolipids as potential immunologic adjuvants
Journal of Medicinal Chemistry, 1980A group of 1-thio-beta-L-fucopyranosides containing hexadecane, 9-octadecene, adamantane, 1,2-diphenyltetrafluoroethane, and 3-hexynyl- and 3,6-dioxaoctylcholesterols were synthesized as potential immunologic adjuvants. Many of these fucosyl lipids and 6-(5-cholesten-3 beta-yloxy)hexyl 1 thioglycosides were found to give good response to subunit A ...
M M, Ponpipom +3 more
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L-Tyrosine as an Immunological Adjuvant
International Archives of Allergy and Applied Immunology, 2009A series of experiments has been carried out to investigate the adjuvant properties of the amino acid L-tyrosine in laboratory animals. Adsorption of various allergenic materials to L-tyrosine was found to enhance the induction of IgG antibodies, but no unusual propensity to stimulate IgE antibody or delayed hypersensitivity was observed ...
A W, Wheeler +3 more
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Potentiality of gelatin microsphere as immunological adjuvant
Vaccine, 1995This paper describes a new attempt to enhance the production of antibody by delivery of an antigen to phagocytic antigen-presenting cells (e.g. macrophages) using gelatin microspheres. A model protein antigen, human gamma globulin (HGG), was incorporated into microspheres composed of gelatin which have an opsonic ability for macrophage phagocytosis ...
R, Nakaoka, Y, Tabata, Y, Ikada
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Immunological adjuvants: a role for liposomes
Immunology Today, 1990Recent technological advances have resulted in the production of safe subunit and synthetic small peptide vaccines. These vaccines are weakly or non-immunogenic and cannot, therefore, be used effectively in the absence of immunological adjuvants (agents that can induce strong immunity to antigens).
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Adjuvant-free immunological manipulation of livestock
Research in Veterinary Science, 1984Mice and sheep were immunised to growth hormone release inhibiting hormone (GHRIH) using a number of systems which avoided conventional adjuvants. GHRIH was linked directly, or via a horse IgG carrier, to algin or purified protein derivative of tuberculin. A conjugate of GHRIH and flagella from Salmonella dublin was also prepared.
C A, Morrison, J, Williams, B N, Perry
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Polymerized Micelles and Their Use as Adjuvants in Immunology
Journal of Pharmaceutical Sciences, 1976A polymerization process is described for the preparation of hydrophilic micelles containing solubilized drug molecules in a colloidal aqueous system of dissolved monomers. A hydrocarbon medium constitutes the outer phase. After secondary solubilization with the aid of selected surfactants, polymerization of micelles under different conditions takes ...
G, Birrenbach, P P, Speiser
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Immunology and Adjuvant Chemoimmunotherapy of Breast Cancer
Archives of Surgery, 1976Antibody against a breast carcinoma antigen was present in patients with breast carcinoma and other cancer more often (P less than .05) than in normal women. The incidence of antibody in women with breast carcinoma correlated with the presence or absence of gross tumor, and the titer of antibody paralleled the clinical course.
F C, Sparks +5 more
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Immunology of TLR-independent vaccine adjuvants
Current Opinion in Immunology, 2009Vaccine adjuvants target the innate immune system to enhance the immunogenicity of coadministered antigens. Dendritic cells (DCs) are responsible for antigen uptake and presentation to naïve T cells and represent a key target of adjuvant activity. Adjuvants derived from microbial components, such as Toll-like receptor (TLR) agonists, elicit innate ...
Ennio, De Gregorio +2 more
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