Results 31 to 40 of about 14,767 (273)
Cutaneous T‐cell lymphomas: 2023 update on diagnosis, risk‐stratification, and management
American Journal of Hematology, Volume 98, Issue 1, Page 193-209, January 2023., 2023 Abstract Disease Overview Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell neoplasms involving the skin, the majority of which may be classified as Mycosis Fungoides (MF) or Sézary Syndrome (SS). Diagnosis The diagnosis of MF or SS requires the integration of clinical and histopathologic data.
Alexandra C. Hristov +2 more
wiley +1 more source
A statistical mechanics approach to autopoietic immune networks [PDF]
, 2010 The aim of this work is to try to bridge over theoretical immunology and disordered statistical mechanics. Our long term hope is to contribute to the development of a quantitative theoretical immunology from which practical applications may stem. In order to make theoretical immunology appealing to the statistical physicist audience we are going to ...
arxiv +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Dendritic Cell-Targeted Vaccines
Frontiers in Immunology, 2014 Despite significant effort, the development of effective vaccines inducing strong and durable T cell responses against intracellular pathogens and cancer cells has remained a challenge.
Lelia eDelamarre, Lillian eCohn
doaj +1 more source
Allergic Rhinitis: What Do We Know About Allergen-Specific Immunotherapy?
Frontiers in Allergy, 2021 Allergic rhinitis (AR) is an IgE-mediated disease that is characterized by Th2 joint inflammation. Allergen-specific immunotherapy (AIT) is indicated for AR when symptoms remain uncontrolled despite medication and allergen avoidance. AIT is considered to
Tadech Boonpiyathad +5 more
doaj +1 more source
Local vaccination and systemic tumor suppression via irradiation and manganese adjuvant in mice [PDF]
arXiv, 2021 Presently 4T-1 luc cells were irradiated with proton under ultra-high dose rate FLASH or with gamma-ray with conventional dose rate, and then subcutaneous vaccination with or without Mn immuno-enhancing adjuvant into the mice for three times. One week later, we injected untreated 4T-1 luc cells on the other side of the vaccinated mice, and found that ...
arxiv
Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Frontiers in Microbiology, 2016 Malaria parasites engage a multitude of strategies to evade the immune system of the host, including the generation of polymorphic T cell epitope sequences, termed altered peptide ligands (APLs).
Kirsty Lee Wilson +2 more
doaj +1 more source
Journal for ImmunoTherapy of Cancer, 2022 Background A goal of cancer vaccines is to induce strong T cell responses to tumor antigens, but the delivery method, schedule, and formulation of cancer vaccines have not yet been optimized.
Craig L Slingluff +4 more
doaj +1 more source
Immunological recognition by artificial neural networks [PDF]
, 2018 The binding affinity between the T-cell receptors (TCRs) and antigenic peptides mainly determines immunological recognition. It is not a trivial task that T cells identify the digital sequences of peptide amino acids by simply relying on the integrated binding affinity between TCRs and antigenic peptides. To address this problem, we examine whether the
arxiv +1 more source