Results 41 to 50 of about 69,334 (300)

Early Clinical and Cerebrospinal Fluid Predictors of 1‐Year Recurrence in Autoimmune GFAP Astrocytopathy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune glial fibrillary acidic protein astrocytopathy (GFAP‐A) is an inflammatory central nervous system disorder with variable outcomes. Relapse occurs in a subset of patients, but early predictors remain unclear. We aimed to identify admission‐available features associated with 1‐year recurrence and develop an interpretable ...
Qingting Hong   +10 more
wiley   +1 more source

Improving the Effectiveness of Adjuvants: Targeting Innate Immune Receptors with a Special Focus on Toll-like Receptor Agonists

open access: yesمجله دانشکده پزشکی اصفهان, 2013
The development of potent and safe adjuvants for generating vaccines capable of inducing protective and long lasting immunity has become an expanding field in vaccine development.
Seyed-Elias Tabatabaeizadeh   +1 more
doaj  

Dendritic Cell-Targeted Vaccines

open access: yesFrontiers in Immunology, 2014
Despite significant effort, the development of effective vaccines inducing strong and durable T cell responses against intracellular pathogens and cancer cells has remained a challenge.
Lelia eDelamarre, Lillian eCohn
doaj   +1 more source

The vaccine-site microenvironment: impacts of antigen, adjuvant, and same-site vaccination on antigen presentation and immune signaling

open access: yesJournal for ImmunoTherapy of Cancer, 2022
Background A goal of cancer vaccines is to induce strong T cell responses to tumor antigens, but the delivery method, schedule, and formulation of cancer vaccines have not yet been optimized.
Craig L Slingluff   +4 more
doaj   +1 more source

Sequestering of damage-associated molecular patterns (DAMPs) : a possible mechanism affecting the immune-stimulating properties of aluminium adjuvants

open access: yes, 2017
Aluminium-based adjuvants (ABAs) have been used in human and veterinary vaccines for decades, and for a long time, the adjuvant properties were believed to be mediated by an antigen depot at the injection site, prolonging antigen exposure to the immune ...
Siesjö, Peter   +11 more
core   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

A model to study the impact of polymorphism driven liver-stage immune evasion by malaria parasites, to help design effective cross-reactive vaccines

open access: yesFrontiers in Microbiology, 2016
Malaria parasites engage a multitude of strategies to evade the immune system of the host, including the generation of polymorphic T cell epitope sequences, termed altered peptide ligands (APLs).
Kirsty Lee Wilson   +2 more
doaj   +1 more source

The Association of Physical Function With Psychosocial Patient‐Reported Outcomes in People With Systemic Lupus Erythematosus

open access: yesArthritis Care &Research, EarlyView.
Objective To evaluate how modifiable psychosocial factors and fatigue relate to physical functioning in patients with systemic lupus erythematosus (SLE). Methods In this cross‐sectional study of two demographically distinct cohorts (Approaches to Positive, Patient‐Centered Experiences of Aging with Lupus [APPEAL] and California Lupus Epidemiology Study
Mrinalini Dey   +8 more
wiley   +1 more source

Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection

open access: yesFrontiers in Immunology, 2018
Accumulating evidence suggests important functions for human Toll-like receptor 8 in vivo in tuberculosis and autoimmune diseases. However, these studies are limited by the lack of specific agonists and by the fact that the homology of TLR8 in human and ...
Jun Tang   +23 more
doaj   +1 more source

In Situ Therapeutic Cancer Vaccination with an Oncolytic Virus Expressing Membrane-Tethered IL-2

open access: yesMolecular Therapy: Oncolytics, 2020
Successful in situ therapeutic vaccination would allow locally delivered oncolytic virus (OV) to exert systemic immunologic effects on metastases and improve survival.
Weilin Liu   +5 more
doaj   +1 more source

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