Results 61 to 70 of about 15,663 (264)
Vaccine Development against the Renin-Angiotensin System for the Treatment of Hypertension
International Journal of Hypertension, 2019 Hypertension is a global public health issue and the most important preventable cause of cardiovascular diseases. Despite the clinical availability of many antihypertensive drugs, many hypertensive patients have poor medication adherence and blood ...
Tatsuhiko Azegami, Hiroshi Itoh
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Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro
Advanced Science, EarlyView.The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel +15 more
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Establishing the pig as a large animal model for vaccine development against human cancer
Frontiers in Genetics, 2015 Immunotherapy has increased overall survival of metastatic cancer patients, and cancer antigens are promising vaccine targets. To fulfill the promise, appropriate tailoring of the vaccine formulations to mount in vivo cytotoxic T cell (CTL) responses ...
Nana Haahr Overgaard +8 more
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Advanced Science, EarlyView.ABSTRACT The muscle capsule of Trichinella is a critical structure that impedes immune attacks and drug penetration, yet the molecular mechanisms underlying its formation remain poorly understood. Using a high‐quality super‐pangenome comprising 12 Trichinella species, we compared extensive genomic variations between encapsulating and non‐encapsulating ...
Qingbo Lv +8 more
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Arquivos Brasileiros de Cardiologia, 2007 Apesar de relativamente recente, nota-se um acúmulo crescente e robusto de evidências experimentais e clínicas que apontam um estado gradativo de ativação imune-inflamatória em pacientes com insuficiência cardíaca (IC).
Angelo Michele de Candia +2 more
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Advanced Science, EarlyView.A multifunctional nanoagonist (cDZ@IP) enables nano‐metabolite–driven multimodal activation of the STING pathway and enhanced immune recognition, achieving potent antitumor immunity and suppressing tumor growth and metastasis. This strategy highlights the rational design of therapeutic metabolites and establishes a new paradigm bridging nanomedicine ...
Kepeng Hu +17 more
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Ciência Rural, 2002 O Pythium insidiosum é um fungo zoospórico que se desenvolve em locais alagadiços e que pode infectar humanos e animais, principalmente eqüinos. A infecção natural nesta espécie resulta em pitiose clínica, uma doença granulomatosa de difícil tratamento ...
Alexandre Trindade Leal +7 more
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Immunological Adjuvants and Vaccines [PDF]
, 1989 Vaccination, chiefly responsible for the eradication of smallpox and the control of poliomyelitis and German measles in man and of foot-and mouth, Marek's and Newcastle disease in domestic animals, remains the best answer to infectious diseases. Early vaccines were live wild type organ isms but these have been largely replaced by attenuated or killed ...
openaire +1 more source
Advanced Science, EarlyView.RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu +13 more
wiley +1 more source
Zhongguo aizheng zazhi, 2019 Chimeric antigen receptor (CAR) T-cells have recently provided promising advances as a novel immunotherapeutic approach for cancer treatment especially in B-cell malignancies.
潘泽雁, 湛先保
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