Results 61 to 70 of about 69,334 (300)

Adjuvants, immunomodulators, and adaptogens

, 2022
Vaccine adjuvants are a diverse range of compounds that have the ability to improve vaccine potency through more efficient antigen presentation and delivery, stimulation of the innate immune system or prolonged effect on adaptive immunity.
Marina Luchner, Sebnem Ercelen Ceylan, Górska, Sabina, Thakur, Aneesh, Christensen, Dennis, Agnieszka Razim, Malachy Chigozie Ugwu, Longet, Stephanie, Ceylan, Sebnem Ercelen, Erik B. Lindblad, Stephanie Longet, Bror Morein, Lindblad, Erik B., George Corby, Milicic, Anita, Fergusson, Joannah, Luchner, Marina, Kefei Hu, Dennis Christensen, Hu, Kefei, Morein, Bror, Sabina Górska, Slavcho Mrenoshki, Gizurarson, Sveinbjorn, Aneesh Thakur, Corby, George, Ugwu, Malachy Chigozie, Sveinbjorn Gizurarson, Reinke, Sören, Joannah Fergusson, Razim, Agnieszka, Anita Milicic, Sören Reinke, Mrenoshki, Slavcho   +33 more
core   +1 more source

Caregiver Perspectives on the Burden of Disease and Treatment in Uncontrolled Gout

Arthritis Care &Research, EarlyView.
Objective Uncontrolled gout (UG) refers to persistently elevated serum urate (SU) levels >6 mg/dL and ongoing gout symptoms despite use of urate‐lowering therapy (ULT). The objective of this study was to evaluate the burden associated with informal caregiving for individuals with UG.
Angelo Gaffo, Bhavisha Desai, Abiola Oladapo, Nana Kragh, Rebekah Zincavage, Brad Padilla, Naomi Schlesinger   +6 more
wiley   +1 more source

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin. [PDF]

, 2009
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT ...
Kromann Ingrid, Woodrow, M, Novicki Deborah, Huo, Z, Del Giudice Giuseppe, Novicki, D, Rappuoli Rino, Thierry-Carstensen, B, Susan Barnett, Galiza, E, David J M Lewis, Rafaela Giemza, Andersen, P, Peter Andersen, Lewis David J. M., Barnett Susan, Maria Woodrow, Kromann, I, Giuseppe Del Giudice, Thierry-Carstensen Birgit, Giemza Rafaela, Ingrid Kromann, Andersen Peter, Lewis, DJ, Galiza Eva, Giemza, R, Huo Zhiming, Woodrow Maria, Deborah Novicki, Eva Galiza, Birgit Thierry-Carstensen, Rino Rappuoli, Del Giudice, G, Rappuoli, R, Barnett, S, Zhiming Huo   +35 more
core   +1 more source

Clinical Validation of Artificial Intelligence (AI)‐based Cartilage Segmentation Predicting Knee Replacement

Arthritis Care &Research, Accepted Article.
Objective For cartilage morphology to serve as a scalable endpoint in clinical trials, analyses should be performed automatically without human interaction. To clinically validate artificial intelligence (AI)‐based analysis, we studied cartilage loss from MRI prior to knee replacement.
Felix Eckstein, David J. Hunter, C. Kent Kwoh, Wolfgang Wirth   +3 more
wiley   +1 more source

Dynamic changes in cellular infiltrates with repeated cutaneous vaccination: a histologic and immunophenotypic analysis

Journal of Translational Medicine, 2010
Background Melanoma vaccines have not been optimized. Adjuvants are added to activate dendritic cells (DCs) and to induce a favourable immunologic milieu, however, little is known about their cellular and molecular effects in human skin.
Schaefer Jochen T, Patterson James W, Deacon Donna H, Smolkin Mark E, Petroni Gina R, Jackson Emily M, Slingluff Craig L   +6 more
doaj   +1 more source

Design of vaccine adjuvants incorporating TNF superfamily ligands and TNF superfamily molecular mimics

, 2013
TNF superfamily ligands play a critical role in the regulation of adaptive immune responses, including the costimulation of dendritic cells, T cells, and B cells.
Sachin Gupta, Gupta, Sachin, Geoffrey W. Stone, Termini, James, Stone, Geoffrey, James M. Termini, Saravana Kanagavelu, Kanagavelu, Saravana   +7 more
core   +1 more source

Elevated liver enzymes is not an impediment to allopurinol dose escalation: an observational cohort study

Arthritis Care &Research, Accepted Article.
Objective Routine liver enzyme monitoring is advocated while on allopurinol but supporting guidance is lacking. We assessed the incidence and factors associated with elevated liver enzymes in gout patients commenced on allopurinol. Methods 150 patients with gout and normal baseline serum aminotransferases initiated on allopurinol were followed ...
May Shuen Tang, Qai Ven Yap, Peter Pak Moon Cheung, Amelia Santosa, Gim Gee Teng   +4 more
wiley   +1 more source

Estudo da cinética do infiltrado celular inflamatório induzido por adjuvantes de vacinas em bolhas de ar formadas no subcutâneo de camundongos [PDF]

, 2004
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-graduação em Biotecnologia.A inflamação é uma resposta do organismo a um estímulo agressor, químico, físico ou biológico, que tem como ...
Rezende, Fabíola Cunha Bernardes e
core  

Prevalence of Dietary Supplement Use and Potential Medication Interactions Among Adults with Systemic Lupus Erythematosus

Arthritis Care &Research, Accepted Article.
Objective To characterize the prevalence and correlates of dietary supplement use, identify commonly used supplements, and evaluate potential supplement–medication interactions among adults with systemic lupus erythematosus (SLE). Methods We analyzed cross‐sectional data from 451 adults in the Approaches to Positive, Patient‐centered Experiences of ...
Sarah L. Patterson, Russell Ellyson, Jessica Fitzpatrick, Ghizlane Yaakoubi, Bradley Pearce, S. Sam Lim, Jinoos Yazdany, Laura C. Plantinga   +7 more
wiley   +1 more source

PLoS One [PDF]

Safe and effective immunologic adjuvants are often essential for vaccines. However, the choice of adjuvant for licensed vaccines is limited, especially for those that are administered intradermally.

core   +2 more sources