Results 51 to 60 of about 204,124 (382)

Carbohydrate-based adjuvants

Drug Discovery Today: Technologies, 2020
Carbohydrate adjuvants are safe and biocompatible compounds usable as sustained delivery systems and stimulants of ongoing humoral and cellular immune responses, being especially suitable for the development of vaccines against intracellular pathogens where alum is useless.
Garcia-Vello, Pilar, Speciale, Immacolata, Chiodo, Fabrizio, Molinaro, Antonio, De Castro, Cristina   +4 more
openaire   +6 more sources

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

FEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze, Stéphane Canaan, Alexandre Gouzy, Pierre Santucci   +3 more
wiley   +1 more source

Adjuvant Treatment of Melanoma [PDF]

ISRN Dermatology, 2011
Melanomas represent 4% of all malignant tumors of the skin, yet account for 80% of deaths from skin cancer.While in the early stages patients can be successfully treated with surgical resection, metastatic melanoma prognosis is dismal. Several oncogenes have been identified in melanoma as BRAF, NRAS, c-Kit, and GNA11 GNAQ, each capable of activating ...
Moreno Nogueira, J A, Valero Arbizu, M, Pérez Temprano, R   +2 more
openaire   +6 more sources

Carbohydrate-Based Adjuvants for Vaccine Production

Биопрепараты: Профилактика, диагностика, лечение, 2018
Addition of adjuvants is a generally recognized method of enhancing the immunogenicity of vaccines. There is a large variety of  adjuvants, therefore the choice of an adjuvant is based on the  comparison of adjuvants efficacy in animal models, as well as 
S. S. Kurashova, T. K. Dzagurova, A. A. Ishmukhametov, M. S. Egorova, M. V. Balovneva, S. E. Sotskova, E. A. Tkachenko   +6 more
doaj   +1 more source

Adjuvants : an essential component of neisseria vaccines [PDF]

, 2009
Adjuvants may be classified into delivery systems and immune potentiator or modulator molecules based on their mechanism of action. Neisseria vaccines containing traditional adjuvants such as aluminium salts have existed for long time, but meningitis ...
Acevedo, R., Balbao, J., Cabrera, O., Cuello, M., del Campo, J., Ferro, Valerie A., Gonzales, E., Romeu, B., Zayas, C.   +8 more
core  

Innate immunity: ignored for decades, but not forgotten. [PDF]

, 2012
The innate immune system must recognize and rapidly respond to microbial pathogens, providing a first line of host defense. This is accomplished through an array of pattern recognition receptors (PRRs) that reside in specific subcellular compartments and
Adam, Alexopoulou, Blander, Brightbill, Busch, Coley, Coley, Davis, Diebold, Doyle, Doyle, Eisenbarth, Ellouz, Fehleisen, Ferwerda, Freund, Girardin, Girardin, Glenny, Gresser, Hansen, Hayashi, Hemmi, Hemmi, Inohara, Janeway, Kleinerman, Krutzik, Lai, Lande, Langerhans, Lewis, Liu, Liu, Liu, Martinon, Martinon, Medzhitov, Metchnikoff, Modlin, Morales, Morton, Pollack, Poltorak, Ramon, Ramon, Robert L. Modlin, Schauber, Specter, Sugimoto, Terhorst, Thoma-Uszynski, Watanabe, Yang   +53 more
core   +1 more source

Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells

Molecular Oncology, EarlyView.
In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi, Jérome Vialaret, Christophe Hirtz, Catherine Alix‐Panabières   +3 more
wiley   +1 more source

Simultaneous immunization with Omp25 and L7/L12 provides protection against brucellosis in mice [PDF]

, 2020
Currently ...
Aggarwal, Somya, Bhatnagar, Rakesh, Gupta, Sonal, Mohan, Surender, Somani, Vikas Kumar   +4 more
core   +2 more sources

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge. [PDF]

, 2015
C3H/HeN female mice were vaccinated with native Chlamydia muridarum major outer membrane protein (MOMP), using Montanide+CpG or Alum+CpG as adjuvants. Negative control groups were immunized with ovalbumin (OVA) and the same adjuvants. As positive control,
de la Maza, Luis M, Pal, Sukumar, Tatarenkova, Olga V   +2 more
core   +1 more source