Results 11 to 20 of about 26,392 (248)

Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition

Pharmaceutics, 2023
Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez, Armin Sadighi, Yeseul Ahn, Steve F. Keller, Julius O. Enoru   +4 more
doaj   +1 more source

Flavones scaffold of Chromolaena odorata as a potential xanthine oxidase inhibitor: Induced Fit Docking and ADME studies [PDF]

BioImpacts, 2020
Introduction: Gout is a type of painful inflammation initiated by the interactions between monosodium urate crystals and connective tissue. Xanthine oxidase (XO) catalyzes the oxidation of hypoxanthine to xanthine, then to uric acid.
Babatomiwa Kikiowo, Adewale Joseph Ogunleye, Olumide Kayode Inyang, Niyi Samuel Adelakun, Olaposi Idowu Omotuyi, Damilohun Samuel Metibemu, Temitope Israel David, Oluwatoyin Olajide Oludoyi, Taiwo Tolulope Ijatuyi   +8 more
doaj   +1 more source

Diversifying the chloroquinoline scaffold against SARS-COV-2 main protease: Virtual screening approach using cross-docking, sitemap analysis and molecular dynamics simulation [PDF]

Journal of the Serbian Chemical Society, 2023
The absence of designated remedies for coronavirus disease 19 (Covid-19) and the lack of treatment protocols drove scientists to propose new small molecules and to attempt to repurpose existing drugs against various targets of severe acute respiratory ...
Aissaoui Mohamed, Belhani Billel, Boulebnane Abdelmoumen, Bouzina Abdeslem, Djilani Salah Eddine   +4 more
doaj   +1 more source

adm [PDF]

, 2019
Abstrak— This article aims to fulfill administrative duties and educational supervision. Where this article is titled "Administration of special service". This article was created to fulfill the administration and supervision courses. This article is about how special service in the world of education.
openaire   +2 more sources

The Forbidden Reward. The Emergence of Parent-Child Conflicts About Food Over Time and the Influence of Parents' Communication Strategies and Feeding Practices

Frontiers in Public Health, 2021
One of the most critical arenas for conflicts between parents and their children relates to food. Although parent-child conflicts about food are a real occurrence, this form of parent-child interaction has been rarely examined.
Ines Spielvogel, Brigitte Naderer, Alice Binder, Jörg Matthes   +3 more
doaj   +1 more source

Biological evaluation of selected metronidazole derivatives as anti-nitroreductase via in silico approach

Eclética Química, 2022
The 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (2HMN) is a powerful antibacterial and antiparasitic drug used alongside other drugs against Helicobacter pylori infection and was investigated the effects of substituents: –OH (A), H (B), –SPh (C), –COOH (
Moriam Dasola Adeoye, Abel Kolawole Oyebamiji, Mojeed Ayoola Ashiru, Rasheed Adewale Adigun, Olabisi Hadijat Olalere, Banjo Semire   +5 more
doaj   +1 more source

In Silico Pharmacokinetics Study of 2,5-Dibenzylidenecyclopentanone Analogs as Mono-Ketone Versions of Curcumin [PDF]

BIO Web of Conferences, 2023
The absorption-distribution-metabolism-excretion (ADME) profile is a crucial parameter that indicates the pharmacokinetics of the drug. The pharmacokinetic properties of a drug represent the fate of the drug in the body.
Marbun Prajona, Hakim Arief Rahman, Sri Octa Ujiantari Navista, Sulistyo Ari Sudarmanto Bambang, Endro Nugroho Agung   +4 more
doaj   +1 more source

Cocrystal solubility-pH and drug solubilization capacity of sodium dodecyl sulfate – mass action model for data analysis and simulation to improve design of experiments

ADMET and DMPK, 2018
This review discusses the disposition of the anionic surfactant, sodium dodecyl sulfate (SDS; i.e., sodium lauryl sulfate), to solubilize sparingly-soluble drugs above the surfactant critical micelle concentration (CMC), as quantitated by the ...
Alex Avdeef
doaj   +1 more source

Prediction of aqueous intrinsic solubility of druglike molecules using Random Forest regression trained with Wiki-pS0 database

ADMET and DMPK, 2020
The accurate prediction of solubility of drugs is still problematic. It was thought for a long time that shortfalls had been due the lack of high-quality solubility data from the chemical space of drugs.
Alex Avdeef
doaj   +1 more source

Do you know your r2?

ADMET and DMPK, 2020
The prediction of solubility of drugs usually calls on the use of several open-source/commercially-available computer programs in the various calculation steps.
Alex Avdeef
doaj   +1 more source