Results 41 to 50 of about 30,899 (248)
PharmaceuticsCurrent drug development tends towards complex chemical molecules, referred to as “beyond rule of five” (bRo5) compounds, which often exhibit challenging physicochemical properties.
Patricia Muschong +4 more
doaj +1 more source
Lessons From Drug Discovery for Cryoprotective Agent Design: An AI‐Oriented Perspective
Advanced Science, EarlyView.Cryoprotectant design is reframed through the lens of drug discovery as a multiparameter optimization problem. This perspective highlights how AI and systematic design strategies could enable safer, more effective cryoprotectants, while identifying key limitations that currently constrain predictive progress in cryobiology. ABSTRACT Cryopreservation is
Dominika Wilczok +4 more
wiley +1 more source
Оцінка ADME-Tox властивостей молекул. Методи навчання багатозадачних нейронних мереж [PDF]
, 2022 Магістерська дисертація: 110 с., 28 табл., 43 рис., 1 додаток, 46 посилань. Об’єкт дослідження: ADME-Tox властивості молекули. Мета дослідження: аналіз ADME-Tox параметрів, побудова багатозадачної нейронної мережі із використанням графових ...
Островський, Захар Юрійович
core
, 2020 Supervision is a help in the realization of professional services provided by people who are more skilled in increasing professional capabilities, especially in the learning process of teaching. The aim of supervision is to improve the teaching learning process, which involves the teacher and students, through action, guidance, and direction.
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ADMET and DMPKBackground and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways. This commentary examines the characteristics of
Alex Avdeef
doaj +1 more source
Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity
Advanced Science, EarlyView.Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai +7 more
wiley +1 more source
Endogenous plasma riboflavin is not a viable BCRP biomarker in human
Clinical and Translational ScienceRecent reports suggest that plasma riboflavin may serve as a biomarker for BCRP inhibition in humans. However, the clinical data supporting this claim have been limited, with only two studies showing modest increases in riboflavin levels after ...
John P. Savaryn +6 more
doaj +1 more source
Physica Scripta, 2015 This tribute to the memory of my old friend and collaborator, Richard Arnowitt, focuses on the history, results and physical significance of the Arnowitt-Deser-Misner formulation of General Relativity, starting from its birth in 1958-9 through its completion, in a series of over a dozen papers, in 1962-3.
openaire +3 more sources
Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276
Advanced Science, EarlyView.WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan +10 more
wiley +1 more source