Results 41 to 50 of about 26,232 (247)

Conquering the beyond Rule of Five Space with an Optimized High-Throughput Caco-2 Assay to Close Gaps in Absorption Prediction

Pharmaceutics
Current drug development tends towards complex chemical molecules, referred to as “beyond rule of five” (bRo5) compounds, which often exhibit challenging physicochemical properties.
Patricia Muschong, Khader Awwad, Edward Price, Mario Mezler, Manuel Weinheimer   +4 more
doaj   +1 more source

Antibody Conjugates-Recent Advances and Future Innovations

Antibodies, 2020
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to ...
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng   +5 more
doaj   +1 more source

Recapitulating In Vivo Pharmacokinetics and Size‐Dependent Nanomedicine Delivery in a Microfluidic Platform

Advanced Science, EarlyView.
A microfluidic tumor platform integrates pharmacokinetic flow control, vascular‐like barriers, and 3D tumor spheroids to emulate in vivo drug exposure. The system reproduces dynamic concentration–time profiles and enables size‐dependent nanoparticle transport and efficacy evaluation, providing a predictive framework for assessing nanomedicine ...
Su Jeong Kang, Moon Sup Yoon, Jae Min Lee, Min Jeong Jo, Chae Eun Jin, Dae Hwan Shin   +5 more
wiley   +1 more source

Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH

ADMET and DMPK
Background and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways.  This commentary examines the characteristics of
Alex Avdeef
doaj   +1 more source

Giant Direct Magnetoelectric Effect in Nanocomposite CoFe2O4:PVDF‐TrFE Thin Films

Advanced Science, EarlyView.
A novel three‐step grow‐etch‐fill fabrication approach creates structured cobalt ferrite/ferroelectric polymer nanocomposites with high interfacial areas. Driven by efficient strain‐mediated coupling, this crystalline system achieves a giant room‐temperature magnetoelectric coefficient nearly two orders of magnitude higher than other CFO/PVDF‐TrFE thin
Muireann de h‐Óra, Lynette Keeney, Rui Miguel Gonçalves Carvalho, Aliona Nicolenco, Tuhin Maity, Jordi Sort, Luís Amorim, Pedro Martins, Judith MacManus‐Driscoll   +8 more
wiley   +1 more source

Endogenous plasma riboflavin is not a viable BCRP biomarker in human

Clinical and Translational Science
Recent reports suggest that plasma riboflavin may serve as a biomarker for BCRP inhibition in humans. However, the clinical data supporting this claim have been limited, with only two studies showing modest increases in riboflavin levels after ...
John P. Savaryn, Ryota Kikuchi, Yuli Qian, Qin C. Ji, Gary J. Jenkins, Daniel A. J. Bow, Mohamed‐Eslam F. Mohamed   +6 more
doaj   +1 more source

The legacy of ADM [PDF]

Physica Scripta, 2015
This tribute to the memory of my old friend and collaborator, Richard Arnowitt, focuses on the history, results and physical significance of the Arnowitt-Deser-Misner formulation of General Relativity, starting from its birth in 1958-9 through its completion, in a series of over a dozen papers, in 1962-3.
openaire   +3 more sources

Stimulation of OGG1 Enhances Oxidative DNA Damage Repair and Protects Against Acute Liver Failure by Acetaminophen

Advanced Science, EarlyView.
Chemical switching of OGG1 by CMM‐98 accelerates oxidative DNA damage repair and enhances hepatocyte resilience during acetaminophen‐induced acute liver injury. By promoting efficient processing of OGG1‐generated repair intermediates, CMM‐98 reduces oxidative damage, preserves cellular integrity, and protects against acute liver failure, identifying ...
Zhenjun Zhao, Rahul Upadhyay, Alice Eddershaw, Chenchen Wang, Yudong Zhao, Olov Wallner, Jinhye Ryu, Nayere Taebnia, Heather Gildie, Emma Scaletti‐Hutchinson, Jonathan R. Davies, Nicole Ziegler, Andreas Krämer, Samantha C. Robinson, Marek Varga, Karolina Singerova, Zuzanna Szaruga, Elisée Wiita, İrşil Güneş, Sheila S. David, Stefan Knapp, Aimo Kannt, Miguel de Vega, Pål Stenmark, Volker M Lauschke, Maurice Michel   +25 more
wiley   +1 more source

Cytotoxic potential of novel N-formyl pyrazolines derived from vanillin [PDF]

Kragujevac Journal of Science
In the reaction of vanillin and acetone under Claisen-Schmidt conditions, dehydrozingerone, a very attractive biologically active compound, is obtained.
Muškinja Jovana M., Marković Violeta R., Todorović Tamara Lj, Luković Jovan D., Nikolić Ivana S., Mitrović Marina M., Ratković Zoran R.   +6 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source