Results 51 to 60 of about 30,899 (248)

ADME processes in cachexia.

, 2013
ADME processes in cachexia.
Stefan D. Anker (196148), Mitja Lainscak (398627), Katja Trobec (481499), Mojca Kerec Kos (481500), Jochen Springer (196153), Stephan von Haehling (357511)   +5 more
core   +1 more source

A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity

Biomedical and Biotechnology Research Journal, 2023
Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking ...
Naman Vijaykumar Jain, Omkar Pravin Tambekar, Deepali Amol Bansode, S L Bodhankar   +3 more
doaj   +1 more source

A Machine Vision‐Guided Microphysiological Platform With Automated Microfluidics Enables Longitudinal Biomarker Monitoring and Emulation of Translationally Relevant Exposure Scenarios

Advanced Science, EarlyView.
A pneumatically actuated multi‐tissue microphysiological system is integrated with AI‐based machine vision and automatic sampling and replenishment systems. The platform allows for the emulation of translationally relevant long‐term pharmacokinetic exposure scenarios for multiple weeks while enabling longitudinal monitoring of response biomarkers ...
Jibbe Keulen, Yi Zhong, Laura Dangel, Sonia Youhanna, Reza Zandi Shafagh, Jinhye Ryu, Domnica‐Gabriela Gurau, Mathias Haag, Thomas E. Mürdter, Yingxin Liang, Iro Beligiani, Nicole Ziegler, Sabine Willems, Nayere Taebnia, Wouter van der Wijngaart, Volker M. Lauschke   +15 more
wiley   +1 more source

Profil ADME dari Entitas Molekul Baru yang Disetujui oleh FDA Tahun 2021: Suatu Kajian In Silico [PDF]

, 2022
Aspek farmakokinetik dan farmakodinamik yang diwakili oleh sifat adsorpsi, distribusi, metabolisme, ekskresi (ADME) merupakan syarat penting suatu obat dapat menuju targetnya.
Hairunnisa, Hairunnisa, Arief, Ihsanul
core   +1 more source

Exploration of Novel Biomarkers for Neurodegenerative Diseases Using Proteomic Analysis and Ligand-Binding Assays

Biomedicines
Background/Objectives: Neurodegenerative diseases are a major cause of morbidity and mortality worldwide, and their public health burden continues to increase.
Annalena Kenzelmann, Christina Boch, Ronny Schmidt, Mario Richter, Michael Schulz   +4 more
doaj   +1 more source

Cytotoxic potential of novel N-formyl pyrazolines derived from vanillin [PDF]

Kragujevac Journal of Science
In the reaction of vanillin and acetone under Claisen-Schmidt conditions, dehydrozingerone, a very attractive biologically active compound, is obtained.
Muškinja Jovana M., Marković Violeta R., Todorović Tamara Lj, Luković Jovan D., Nikolić Ivana S., Mitrović Marina M., Ratković Zoran R.   +6 more
doaj   +1 more source

Conformational Analysis and DFT Investigations of 1-(4-Fluorophenyl)Piperazine by ELF and LOL, Inhibitory activity against Alzheimer’s Disease, and ADME Prediction

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2022
This study reports 1-(4-Fluorophenyl)Piperazine molecule structural and electronic properties calculated at the DFT/B3LYP level. A potential energy surface scan along the rotational bonds discovered the most stable minimum energy conformer of the title ...
Sibel Çelik
doaj   +1 more source

ADME related patterns to predict the prognosis and immune therapy of colon cancer patients. [PDF]

Sci Rep
Genes involved in absorption, distribution, metabolism, and excretion (ADME) regulate drug pharmacokinetics, yet their prognostic value in colorectal cancer (CRC) remains underexplored.
Liu Y, Liu J, Tu X, Nie J, Li H, Yu G.
europepmc   +2 more sources

Decoding Tattoo and Permanent Makeup Pigments: Linking Physicochemical Properties to Absorption, Distribution, Metabolism, and Elimination Profiles Using Quantitative Structure–Activity Relationship (QSAR)‐Based New Approach Methodologies (NAMs)

Advanced Intelligent Discovery, EarlyView.
This study applies QSAR‐based new approach methodologies to 90 synthetic tattoo and permanent makeup pigments, revealing systemic links between their physicochemical properties and absorption, distribution, metabolism, and elimination profiles. The correlation‐driven analysis using SwissADME, ChemBCPP, and principal component analysis uncovers insights
Girija Bansod, Ajay Vikram Singh, Preeti Bhardwaj, Tulika Rai, Sweta Vijay Nakhale, Amruta Shelar, Rajendra Patil, Peter Laux, Andreas Luch, Christopher J. Osgood, Michael W. Stacey   +10 more
wiley   +1 more source

ADME profile of NEU-4893.

, 2019
ADME profile of NEU-4893.
Miguel Navarro (176103), Guiomar Pérez-Moreno (843822), Raquel García-Hernández (292595), Conor R. Caffrey (113916), María S. Martínez-Martínez (6316193), Gloria Ceballos-Pérez (6316187), Pilar Manzano (650253), Lori Ferrins (1365060), Francisco Gamarro (292598), Luis Miguel Ruiz-Pérez (843824), Dolores González-Pacanowska (501255), Domingo I. Rojas-Barros (650247), Veronica Gomez-Pérez (6316190), Michael P. Pollastri (345704), Rosario Diaz-Gonzalez (345689), Dana M. Klug (6194387)   +15 more
core   +1 more source