Results 51 to 60 of about 50,348 (248)

Discovery of TUG-770: a highly potent free fatty acid receptor 1 (FFA1/GPR40) agonist for treatment of type 2 diabetes [PDF]

, 2013
Free fatty acid receptor 1 (FFA1 or GPR40) enhances glucose-stimulated insulin secretion from pancreatic β-cells and currently attracts high interest as a new target for the treatment of type 2 diabetes.
Blad C. C., Briscoe C. P., Burant C. F., Christiansen E., Christiansen E., Christiansen E., Christiansen E., Christiansen E., Christiansen E., Holliday N. D., Hopkins A. L., Itoh Y., Kotarsky K., Leeson P. D., Medina J. C., Negoro N., Sasaki S., Satoh T., Shimpukade B.   +18 more
core   +1 more source

Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications

Advanced Science, EarlyView.
This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang, Hanxu Chen, Yile Fang, Yuanjin Zhao   +3 more
wiley   +1 more source

Exploration of Novel Biomarkers for Neurodegenerative Diseases Using Proteomic Analysis and Ligand-Binding Assays

Biomedicines
Background/Objectives: Neurodegenerative diseases are a major cause of morbidity and mortality worldwide, and their public health burden continues to increase.
Annalena Kenzelmann, Christina Boch, Ronny Schmidt, Mario Richter, Michael Schulz   +4 more
doaj   +1 more source

The legacy of ADM [PDF]

Physica Scripta, 2015
This tribute to the memory of my old friend and collaborator, Richard Arnowitt, focuses on the history, results and physical significance of the Arnowitt-Deser-Misner formulation of General Relativity, starting from its birth in 1958-9 through its completion, in a series of over a dozen papers, in 1962-3.
openaire   +3 more sources

Decoding Tattoo and Permanent Makeup Pigments: Linking Physicochemical Properties to Absorption, Distribution, Metabolism, and Elimination Profiles Using Quantitative Structure–Activity Relationship (QSAR)‐Based New Approach Methodologies (NAMs)

Advanced Intelligent Discovery, EarlyView.
This study applies QSAR‐based new approach methodologies to 90 synthetic tattoo and permanent makeup pigments, revealing systemic links between their physicochemical properties and absorption, distribution, metabolism, and elimination profiles. The correlation‐driven analysis using SwissADME, ChemBCPP, and principal component analysis uncovers insights
Girija Bansod, Ajay Vikram Singh, Preeti Bhardwaj, Tulika Rai, Sweta Vijay Nakhale, Amruta Shelar, Rajendra Patil, Peter Laux, Andreas Luch, Christopher J. Osgood, Michael W. Stacey   +10 more
wiley   +1 more source

Endogenous plasma riboflavin is not a viable BCRP biomarker in human

Clinical and Translational Science
Recent reports suggest that plasma riboflavin may serve as a biomarker for BCRP inhibition in humans. However, the clinical data supporting this claim have been limited, with only two studies showing modest increases in riboflavin levels after ...
John P. Savaryn, Ryota Kikuchi, Yuli Qian, Qin C. Ji, Gary J. Jenkins, Daniel A. J. Bow, Mohamed‐Eslam F. Mohamed   +6 more
doaj   +1 more source

Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH

ADMET and DMPK
Background and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways.  This commentary examines the characteristics of
Alex Avdeef
doaj   +1 more source

Analyzing Learned Molecular Representations for Property Prediction

, 2019
Advancements in neural machinery have led to a wide range of algorithmic solutions for molecular property prediction. Two classes of models in particular have yielded promising results: neural networks applied to computed molecular fingerprints or expert-
Barzilay, Regina, Coley, Connor, Eiden, Philipp, Gao, Hua, Guzman-Perez, Angel, Hopper, Timothy, Jaakkola, Tommi, Jensen, Klavs, Jin, Wengong, Kelley, Brian, Mathea, Miriam, Palmer, Andrew, Settels, Volker, Swanson, Kyle, Yang, Kevin   +14 more
core   +2 more sources

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity

Biomedical and Biotechnology Research Journal, 2023
Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking ...
Naman Vijaykumar Jain, Omkar Pravin Tambekar, Deepali Amol Bansode, S L Bodhankar   +3 more
doaj   +1 more source