Results 71 to 80 of about 30,899 (248)
ADME properties of select minor groove binders.
, 2019 ADME properties of select minor groove binders.
Peris Amwayi (237894) +3 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aims In the context of pharmacology and toxicology education, there is a growing shift toward programmatic assessment models that prioritize longitudinal learning, reflection and development of higher‐order cognitive skills. As part of this transition, we are exploring alternative and more meaningful forms of assessment. This qualitative study
Narin Akrawi +2 more
wiley +1 more source
Heatmap showing ADME properties of top 6 hits.
, 2023 Color bar shows ADME properties ranging from low (blue) to high (yellow).
Iqra Ali (15372725) +5 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson +11 more
wiley +1 more source
In silico approaches of gandarusa (Justicia gendarussa Burm. f.) potential for osteoporosis prevention via EGF pathway [PDF]
Journal of Pharmacy & Pharmacognosy ResearchContext: On a cellular level, osteoporosis is a metabolic bone disease caused by osteoclastic bone resorption that is not offset by osteoblastic bone synthesis. This increases the risk of fractures by making bones weak and brittle.
Sri Dinengsih +4 more
doaj +1 more source
Tackling cancer stemness with nanotechnology in the era of precision medicine
BMEMat, EarlyView.Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo +9 more
wiley +1 more source
Оцінка ADME-Tox властивостей молекул. Методи та моделі графових нейронних мереж [PDF]
, 2022 Магістерська дисертація: 111 с., 32 табл., 37 рис., 1 додаток, 38 посилань. Об’єкт дослідження: ADME-Tox властивості молекули. Мета дослідження: аналіз ADME-Tox параметрів, побудова багатозадачної нейронної мережі із використанням графових ...
Возняк, Володимир Зіновійович
core
Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib
Clinical Pharmacology &Therapeutics, EarlyView.Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi +5 more
wiley +1 more source
, 2006 计算ADME （即吸收、分布、代谢和排泄，in silico absorption, metabolism, distribution and excretion）研究是目前药物研发中的前沿领域之一。计算ADME 可以加速药物理性筛选、进行活性预测、指导分子定向优化等多种工作，从而节省药物开发成本，提高效率。 生物物理和化学因素决定了药物ADME 特性。P-glycoprotein （P-gp） 和细胞色素P450 3A4 酶（P450 3A4）分别是人体对药物分子产生生物物理和化学作用的代表性靶蛋白 ...
王永华
core
Biomolecules, 2020 Multidrug resistance in Pseudomonas aeruginosa is a noticeable and ongoing major obstacle for inhibitor design. In P. aeruginosa, uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) acetyltransferase (PaLpxA) is an essential enzyme of lipid A ...
Baki Vijaya Bhaskar +5 more
doaj +1 more source