Results 81 to 90 of about 30,899 (248)

adm kepemimpinan

, 2019
Educational leadershipis a leader in aneducational unit. Without the presence of educational leadership, the educational process including learning will not run effectively. Educational leadership is a leader whose existence can be directly elected, determined by a foundation, or determined by the government.
null mutiararahmadila, Hade Afriansyah
openaire   +2 more sources

Drug ADME

, 2022
The Project done by me is based on analysis of how a drug works and how it is administered to the body and also it's antiviral capacity against covid-19 and other diseases.
openaire   +1 more source

Biomarker‐Based Prediction of OATP1B1 Activity in Clinical Routine—Investigating Coproporphyrins as Markers for Drug–Drug–Gene Interactions

Clinical Pharmacology &Therapeutics, EarlyView.
Coproporphyrin I (CPI) is an established endogenous biomarker for detecting drug–drug interactions (DDIs) involving the hepatic uptake transporter Organic Anion Transporting Polypeptide 1B1 (OATP1B1, gene SLCO1B1). While CPI has been extensively studied in healthy volunteers using controlled pre‐ and post‐OATP1B1‐inhibitor sampling, its applicability ...
Leila Potzel, Anina Zumtaugwald, Anna Bollinger, Chiara Jeiziner, Kurt E. Hersberger, Florine Wiss, Markus L. Lampert, Samuel S. Allemann, Henriette E. Meyer zu Schwabedissen, Céline K. Stäuble   +9 more
wiley   +1 more source

The Studies of Early ADME Properties of Traditional Chinese Medicine

, 2005
There are abundant sources of Traditional Chinese Medicine (TCM) exhibiting favorable pharmacological activities. Due to historical or cultural reasons, most of those have been used as health food or drug without strict experimental evidences or ...
杨凌
core  

Egg plot "a correlation between antibacterial activity and ADME parameter.

, 2022
Egg plot "a correlation between antibacterial activity and ADME parameter.
Mohsin Abbas Khan (14305173), Imtiaz Ahmad (1689523), Javed Ahmed (12595636), Farhat Ullah (768811), Saharish Khaliq (14305170), Irshad Ahmad (554850)   +5 more
core   +1 more source

Characterization of Lysosomal Hydrolases and Transporters and Their Age‐Dependent Variability: Relevance to Drug Metabolism and Transport of Small Molecule and Biologic Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Lysosomes play a key role in the accumulation, catabolism, and transport of endogenous and exogenous metabolites and proteins and are involved in drug metabolism and prodrug activation. However, the protein abundance and interindividual variability of lysosomal drug‐metabolizing enzymes and transporters (DMETs) remain underexplored.
Darshak Gadara, Dilip Kumar Singh, Sandhya Subash, Guihua Yue, Deepak Ahire, Chris Bohl, Maciej Czerwinski, Stephanie Helmstetter, Scott Heyward, Robert S. Jones, Cyrus Khojasteh, Ryota Kikuchi, Priyanka Kulkarni, Bin Ma, Bernard Murray, Chris Seib, Bill Smith, David M. Stresser, Mitchell E. Taub, Ting Wang, Bhagwat Prasad   +20 more
wiley   +1 more source

Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2020
In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time.
Yazgı Dizdaroglu, Canan Albay, Tayfun Arslan, Abdulilah Ece, Emir A. Turkoglu, Asiye Efe, Murat Senturk, Claudiu T. Supuran, Deniz Ekinci   +8 more
doaj   +1 more source

Payload‐Based Clinical Pharmacology Review of Approved Antibody–Drug Conjugates: Commonalities and Considerations for Streamlined Development

Clinical Pharmacology &Therapeutics, EarlyView.
Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu, Qingqing Xiao, Lixuan Qian, Siyuan Sun, Zhu Zhou, Michael Z. Liao, Chunze Li   +6 more
wiley   +1 more source

Predicted ADME parameters (DS v3.5, Accelrys, USA).

, 2014
Predicted ADME parameters (DS v3.5, Accelrys, USA).
P. K. Murthy (191191), Vikas Kushwaha (655643), Feroz Khan (462714), Richa Verma (1599754), Komal Kalani (462711), Mukesh Srivastava (655644), Santosh Kumar Srivastava (462716), Pooja Sharma (204841)   +7 more
core   +1 more source

In vitro ADME Profile for BPN-14136.

, 2020
In vitro ADME Profile for BPN-14136.
Paul G. Pearson (1336791), Boglarka Racz (1336803), Konstantin Petrukhin (1336773), Andras Varadi (6743981)   +3 more
core   +1 more source