Results 61 to 70 of about 30,899 (248)

In vitro ADME evaluation of ND-11543.

, 2020
In vitro ADME evaluation of ND-11543.
Heath A. Weaver (8250483), Garrett C. Moraski (398960), Lisa Woolhiser (6068711), Anne J. Lenaerts (354472), Kate L. Marshall (8250480), Priscille Brodin (57030), Courtney Hastings (6068714), Nathalie Deboosère (8250477), Alexandre Vandeputte (6018650), Marvin J. Miller (398964)   +9 more
core   +1 more source

Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]

Acta Periodica Technologica, 2019
The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z., Karadžić-Banjac Milica Ž., Podunavac-Kuzmanović Sanja O., Ajduković Jovana J.   +3 more
doaj   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

ADME properties for Pyronaridine tetraphosphate.

, 2019
ADME properties for Pyronaridine tetraphosphate.
Robert A. Davey (95393), Christopher Massey (7908404), Joel S. Freundlich (261762), Jason E. Comer (7908407), Sean Ekins (162), Manu Anantpadma (825669), Peter B. Madrid (399913), Thomas R. Lane (6195626)   +7 more
core   +1 more source

Preclinical in vitro screening of newly synthesised amidino substituted benzimidazoles and benzothiazoles

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro.
Livio Racané, Maja Cindrić, Ivo Zlatar, Tatjana Kezele, Astrid Milić, Karmen Brajša, Marijana Hranjec   +6 more
doaj   +1 more source

In vitro ADME and pharmacokinetics of INCB054828.

, 2020
In vitro ADME and pharmacokinetics of INCB054828.
Kevin Bowman (5435744), Wenqing Yao (314606), Xiaoming Wen (1302228), Mark Rupar (2537560), Patricia Feldman (7541663), Yue Zhang (30585), Timothy C. Burn (2332189), Maryanne Covington (2139592), Gregory Hollis (2245555), Krista A. Burke (8741697), Peggy Scherle (2139556), Christine Gardiner (8741703), Richard Wynn (2332183), Reid Huber (2666968), Liangxing Wu (418408), Swamy Yeleswaram (2139574), Sharon Diamond (2139568), Michael Hansbury (8741694), Holly Koblish (5435765), Ronald Klabe (2666971), Maxim Soloviev (8741700), Paul Collier (2069650), Phillip C. C. Liu (8741688), Darlise DiMatteo (8741691), Xin He (48101), Bruce Ruggeri (2080048), Alla Volgina (8741706)   +26 more
core   +1 more source

Acetylpromazine maleate revisited: deep-dive equilibrium analysis revealing drug salt acting as a pH- and pS-stat counter-titrant

AAPS Open
Acetylpromazine is a phenothiazine derivative that is prone to form sub-micellar aggregates and micelles in water above pH 5. This study revisits the determination of the equilibrium constants (Avdeef et al., ADMET DMPK 4:117-178, 2016) describing the ...
Alex Avdeef
doaj   +1 more source

Molecular Docking and ADME Analysis of L-Phe -L-Tyr Dipeptide

Cumhuriyet Science Journal, 2022
Hypertension is a serious risk factor for various diseases. Therefore, lowering and preventing high blood pressure is a significant issue. Blockage of the renin-angiotensin-aldosterone system (RAAS), which controls blood pressure, is important to reduce ...
Serda Kecel Gunduz, Bilge Bıçak
doaj   +1 more source

Antibody Conjugates-Recent Advances and Future Innovations

Antibodies, 2020
Monoclonal antibodies have evolved from research tools to powerful therapeutics in the past 30 years. Clinical success rates of antibodies have exceeded expectations, resulting in heavy investment in biologics discovery and development in addition to ...
Donmienne Leung, Jacqueline M. Wurst, Tao Liu, Ruben M. Martinez, Amita Datta-Mannan, Yiqing Feng   +5 more
doaj   +1 more source

Use of Clotrimazole in Finfish Aquaculture: Mechanistic Insights, Limitations, and Future Directions for Antifungal Therapy

Animal Research and One Health, EarlyView.
This review critically evaluates clotrimazole as a potential antifungal for finfish aquaculture, highlighting strong mechanistic and in vitro efficacy against aquatic mycoses alongside major gaps in in vivo evidence, toxicokinetics, residue safety, and environmental risk, outlining priorities for responsible therapeutic development and regulatory ...
Arya Sen, Debashri Mondal, Thangapalam Jawahar Abraham   +2 more
wiley   +1 more source