Results 31 to 40 of about 26,232 (247)
Angewandte Chemie, EarlyView.BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu +19 more
wiley +2 more sources
, 2019 Abstrak— the term curriculum administration emphasizes efforts to direct the curriculum so that the curriculum can be implemented appropriately in various educational activities. As is known, the curriculum contains planned activities that will be carried out during the teaching and learning process.
openaire +5 more sources
Suggested Improvements for Measurement of Equilibrium Solubility-pH of Ionizable Drugs
ADMET and DMPK, 2015 The accurate prediction of solubility of drug-like molecules is difficult, and perhaps a satisfactory general model is not yet available. The most cited challenge to good prediction has been the lack of enough high-quality and drug-relevant solubility ...
Alex Avdeef
doaj +1 more source
Computational modeling of distribution coefficients and their correlations with pharmacokinetic properties of 17α-picolyl and 17(E)-picolinylidene androstane derivatives [PDF]
Acta Periodica Technologica, 2019 The present study describes the computational modeling of distribution coefficient (logD) of 17α-picolyl and 17(E)-picolinylidene androstane derivatives, as a group of compounds with significant anticancer activities.
Kovačević Strahinja Z. +3 more
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 Newly synthesised benzimidazole/benzotiazole derivatives bearing amidino, namely 3,4,5,6-tetrahydropyrimidin-1-ium chloride, substituents have been evaluated for their potential antitumor activity in vitro.
Livio Racané +6 more
doaj +1 more source
Eclética Química, 2022 The 1-(2-hydroxyethyl)-2-methyl-5-nitroimidazole (2HMN) is a powerful antibacterial and antiparasitic drug used alongside other drugs against Helicobacter pylori infection and was investigated the effects of substituents: –OH (A), H (B), –SPh (C), –COOH (
Moriam Dasola Adeoye +5 more
doaj +1 more source
G2-manifolds and the ADM formalism [PDF]
Differential Geometry and its Applications, 2019 In this paper we study a Hamiltonian function on the cotangent bundle of the space of Riemannian metrics on a 3-manifold $M$ and prove the orbits of the constrained Hamiltonian dynamical system correspond to $G_2$-manifolds foliated by hypersurfaces diffeomorphic to $M\times \mathrm{SO}(3)$.
openaire +3 more sources
, 2020 Supervision is a help in the realization of professional services provided by people who are more skilled in increasing professional capabilities, especially in the learning process of teaching. The aim of supervision is to improve the teaching learning process, which involves the teacher and students, through action, guidance, and direction.
+17 more sources
Scientific ReportsIn vitro cellular assays are indispensable tools for preclinical understanding of therapeutic candidates. Herein, we have outlined methods for robust determination of cellular sensitivities by adapting drug-induced growth-rate inhibition analysis ...
Dolonchampa Maji +5 more
doaj +1 more source
Advanced Science, EarlyView.Model illustrating the proposed mechanism by which chemotherapy‐induced downregulation of OGT disrupts SNAP29 O‐GlcNAcylation, promoting STX17‐SNAP29‐VAMP8 SNARE complex assembly and protective autophagy, leading to chemoresistance, which in turn establishes a feedforward loop to perpetuate drug tolerance.
Liang Tang +9 more
wiley +1 more source