Results 211 to 220 of about 50,348 (248)
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Bioorganic & Medicinal Chemistry, 2004
The prediction from structure of ADME (absorption, distribution, metabolism, elimination) of drug candidates is an important goal to achieve since it can considerably reduce the cost of drug development. Using our database of 10,700 QSAR, we are now reaching the point where we can make many useful comparisons that illustrate how ADME is a practical way
Corwin, Hansch +3 more
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The prediction from structure of ADME (absorption, distribution, metabolism, elimination) of drug candidates is an important goal to achieve since it can considerably reduce the cost of drug development. Using our database of 10,700 QSAR, we are now reaching the point where we can make many useful comparisons that illustrate how ADME is a practical way
Corwin, Hansch +3 more
openaire +3 more sources
Adrenotensin: An ADM gene product with the opposite effects of ADM
Life Sciences, 1995The purpose of the present study was to investigate the effects of putative products of the ADM gene, other than ADM including, prodepin, proADM45-92 and proADM153-185 on cat pulmonary arterial (PA) rings with or without precontraction with U46619. Addition of proADM153-185 (3 x 10(-10)-10(-6) M) increased tension in a concentration-dependent manner in
B, Gumusel +3 more
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A PCM/ADM and ADM/PCM code converter
IEEE Transactions on Acoustics, Speech, and Signal Processing, 1979In this paper a bidirectional code converter system that converts PCM to ADM and ADM to PCM directly in the digital domain is studied. The particular coding schemes chosen for study are the μ-255 PCM with the rate of 64 kbits/s and the continuously variable slope delta modulation (CVSD) with 32 kbits/s.
null Hong Jeong, null Chong Un
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Pharmacophore Modeling for ADME
Current Topics in Medicinal Chemistry, 2013One of the major reasons for late-stage failure of drug candidates is due to problems uncovered in pharmacokinetics during clinical trials. There is now a general consensus for earlier consideration of these effects in the drug discovery process.
Osman F, Guner, J Phillip, Bowen
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Proceedings of the SIGCHI conference on Human factors in computing systems - CHI '85, 1985
ADM is a system for developing user interfaces. We call it a dialog manager; it is similar to what others call a “User Interface Management System” [8]. Although ADM is still being developed, it has been used to construct several applications. A dialog manager divides an application into an “interaction handler,” which interacts with the user,
Andrew J. Schulert +2 more
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ADM is a system for developing user interfaces. We call it a dialog manager; it is similar to what others call a “User Interface Management System” [8]. Although ADM is still being developed, it has been used to construct several applications. A dialog manager divides an application into an “interaction handler,” which interacts with the user,
Andrew J. Schulert +2 more
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Journal of Information Science, 2014
Probabilistic topic models are statistical methods whose aim is to discover the latent structure in a large collection of documents. The intuition behind topic models is that, by generating documents by latent topics, the word distribution for each topic can be modelled and the prior distribution over the topic learned.
Bagheri, Ayoub +2 more
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Probabilistic topic models are statistical methods whose aim is to discover the latent structure in a large collection of documents. The intuition behind topic models is that, by generating documents by latent topics, the word distribution for each topic can be modelled and the prior distribution over the topic learned.
Bagheri, Ayoub +2 more
openaire +1 more source
Current status and future directions of high-throughput ADME screening in drug discovery
Journal of Pharmaceutical Analysis, 2020Wilson Z Shou
exaly