Results 201 to 210 of about 26,232 (247)

Applicability of next-generation risk assessment generic PBK models and their performance within the chemical domain. [PDF]

Arch Toxicol
Spaenig M, Ashraf MW, Bouhifd M, Drake C, Sobanski T, Escher SE.   +5 more
europepmc   +1 more source

Assessing oxime reactivation efficacy using principal component analysis: Insights from nerve agents inhibited human butyrylcholinesterase. [PDF]

ADMET DMPK
Šinko G, Čadež T, Kovarik Z, Hrvat NM.   +3 more
europepmc   +1 more source

Computational evaluation of carnosic acid as a 4EY7 inhibitor for potential anti-Alzheimer therapy. [PDF]

Front Aging Neurosci
Alhamyani A.
europepmc   +1 more source

Recent advances and expanding applications of organoid models in unveiling drug ADME profiles. [PDF]

J Pharm Anal
Zhang G, Zhang R, Shu Z, Zhao J, Yin L, Shi M, Han Y.   +6 more
europepmc   +1 more source

Construction of a curated human pharmacokinetics database for molecular fragment analysis and machine learning applications. [PDF]

Drug Metab Dispos
Cai L, McWilliams M, Zhai J, Xie L, Wang J.   +4 more
europepmc   +1 more source

Computational Identification of New Dual PAK4 and NAMPT Inhibitors. [PDF]

Int J Mol Sci
Wang Y, Minden A.
europepmc   +1 more source

Pharmacokinetics ADME

Heemani Headau, Punit Satpute, Tanushka Pawar, Dr. Arshita Kumari   +3 more
openaire   +2 more sources

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QSAR and ADME

Bioorganic & Medicinal Chemistry, 2004
The prediction from structure of ADME (absorption, distribution, metabolism, elimination) of drug candidates is an important goal to achieve since it can considerably reduce the cost of drug development. Using our database of 10,700 QSAR, we are now reaching the point where we can make many useful comparisons that illustrate how ADME is a practical way
Corwin, Hansch, Albert, Leo, Suresh Babu, Mekapati, Alka, Kurup   +3 more
openaire   +3 more sources

Adrenotensin: An ADM gene product with the opposite effects of ADM

Life Sciences, 1995
The purpose of the present study was to investigate the effects of putative products of the ADM gene, other than ADM including, prodepin, proADM45-92 and proADM153-185 on cat pulmonary arterial (PA) rings with or without precontraction with U46619. Addition of proADM153-185 (3 x 10(-10)-10(-6) M) increased tension in a concentration-dependent manner in
B, Gumusel, J K, Chang, A, Hyman, H, Lippton   +3 more
openaire   +2 more sources