Results 31 to 40 of about 26,392 (248)

adm kurikulum

, 2019
Abstrak— the term curriculum administration emphasizes efforts to direct the curriculum so that the curriculum can be implemented appropriately in various educational activities. As is known, the curriculum contains planned activities that will be carried out during the teaching and learning process.
openaire   +5 more sources

TUGAS ADM

, 2020
Supervision is a help in the realization of professional services provided by people who are more skilled in increasing professional capabilities, especially in the learning process of teaching. The aim of supervision is to improve the teaching learning process, which involves the teacher and students, through action, guidance, and direction.
  +17 more sources

Application of drug-induced growth rate inhibition and intracellular drug exposures for comprehensive evaluation of cellular drug sensitivity

Scientific Reports
In vitro cellular assays are indispensable tools for preclinical understanding of therapeutic candidates. Herein, we have outlined methods for robust determination of cellular sensitivities by adapting drug-induced growth-rate inhibition analysis ...
Dolonchampa Maji, Malerie Wolke, Shamim Khaja, John P. Savaryn, John C. Kalvass, Gary J. Jenkins   +5 more
doaj   +1 more source

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Conquering the beyond Rule of Five Space with an Optimized High-Throughput Caco-2 Assay to Close Gaps in Absorption Prediction

Pharmaceutics
Current drug development tends towards complex chemical molecules, referred to as “beyond rule of five” (bRo5) compounds, which often exhibit challenging physicochemical properties.
Patricia Muschong, Khader Awwad, Edward Price, Mario Mezler, Manuel Weinheimer   +4 more
doaj   +1 more source

Endothelial GPR68 Is Essential for Arteriogenesis and Represents a Therapeutic Target in a Model of Peripheral Artery Disease

Advanced Science, EarlyView.
Endothelial GPR68 is identified as a critical regulator of collateral artery growth in peripheral artery disease. Genetic and pharmacological evidence demonstrates that GPR68 integrates hemodynamic cues to drive monocyte recruitment and inflammatory remodeling, thereby promoting collateral arteriogenesis and tissue perfusion after ischemia ...
Yiyan Song, Senyi Peng, Zhilei Huang, Miao Yu, Mingyue Wu, Yuexin Zhu, Zeyi Zhou, Yongshan Liu, Yalin Zhang, Yu Huang, Zhongxing Wang, Fu‐Li Xiang, Jie Xu   +12 more
wiley   +1 more source

Often neglected steps in transforming drug solubility from single measurement in pure water to physiologically-appropriate solubility-pH

ADMET and DMPK
Background and purpose: The solubility of weakly-ionizable drugs in pure water, Sw, is commonly measured. The pH-dependent properties of the saturated solutions can be surprisingly complex in subtle ways.  This commentary examines the characteristics of
Alex Avdeef
doaj   +1 more source

A comparative molecular docking study of phytocompounds of Ziziphus jujuba lam. with multiple receptors for the cardioprotective activity

Biomedical and Biotechnology Research Journal, 2023
Background: In this study, we have investigated the binding affinity, ADME, and toxicity analysis of various phytocompounds which are present in Ziziphus jujuba on different receptors related to cardioprotective activity by performing molecular docking ...
Naman Vijaykumar Jain, Omkar Pravin Tambekar, Deepali Amol Bansode, S L Bodhankar   +3 more
doaj   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Endogenous plasma riboflavin is not a viable BCRP biomarker in human

Clinical and Translational Science
Recent reports suggest that plasma riboflavin may serve as a biomarker for BCRP inhibition in humans. However, the clinical data supporting this claim have been limited, with only two studies showing modest increases in riboflavin levels after ...
John P. Savaryn, Ryota Kikuchi, Yuli Qian, Qin C. Ji, Gary J. Jenkins, Daniel A. J. Bow, Mohamed‐Eslam F. Mohamed   +6 more
doaj   +1 more source