Results 91 to 100 of about 94,628 (218)

Synthesis of Pyrido[2,3‐d]Azolopyrimidinones: Design and Epidermal Growth Factor Receptor‐Targeted Molecular Docking Toward Novel Anticancer Leads

ChemistryOpen, EarlyView.
New pyrido[2,3‐d]azolopyrimidinones were synthesized and evaluated as potent EGFR‐targeted anticancer leads. Molecular docking and cytotoxicity studies revealed strong receptor binding and submicromolar activity, highlighting this scaffold as a promising framework for future targeted drug development.
Sobhi M. Gomha, Sami A. Al‐Hussain, Basant Farag, AbdElAziz A. Nayl, Wesam Hussein, Abdelwahed R. Sayed, Magdi E. A. Zaki   +6 more
wiley   +1 more source

Antidiabetic potential of Sapindus trifoliatus fruit ethanolic extract: Gas chromatography–mass spectrometry profiling, molecular docking, and in vitro/in vivo evaluation

Journal of Advanced Pharmaceutical Technology & Research
Diabetes mellitus causes vascular, renal, and ocular complications. In this study, we evaluated an ethanolic extract of Sapindus trifoliatus fruit using gas chromatography–mass spectrometry (GC-MS) profiling, molecular docking, and in vitro and in vivo ...
Sarita Rawat, Prashant Kumar Dhakad, Ritu Gilhotra, Kavita Goyal, A. Rekha, Mohit Rana, Rakhi Mishra, Lakshmi Thangavelu, Gaurav Gupta   +8 more
doaj   +1 more source

Expanding the Repertoire of Natural Product-Inspired Ring Pairs for Molecular Recognition of DNA [PDF]

, 2011
A furan amino acid, inspired by the recently discovered proximicin natural products, was incorporated into the scaffold of a DNA-binding hairpin polyamide.
Arcamone F., Belitsky J. M., Best T. P., Boger D. L., Bremer R. E., Chenoweth D. M., Daniel A. Gubler, Dervan P. B., Dervan P. B., Doss R. M., Edelson B. S., Fiedler H. P., Jevgenij A. Raskatov, Jordan L. Meier, Katy A. Muzikar, Kopka M. L., Marques M. A., Matsuda H., Mrksich M., Muzikar K. A., Nickols N. G., Nickols N. G., Olenyuk B. Z., Pelton J. G., Peter B. Dervan, Pilch D. S., Renneberg D., Schneider K., Stover J. S., Wade W. S., White S., Wolter F. E., Woods C. R.   +32 more
core   +3 more sources

Microwave-assisted ADMET polymerization

Tetrahedron Letters, 2015
Abstract Microwave-assisted ADMET polymerization is reported on a series of α,ω-diene monomers, both polar and non-polar. Investigations indicate that of the multiple microwave modes possible, constant power is the most advantageous, providing polymers up to M ‾ w = 31,000 g/mol.
Rojas Jiménez, Giovanni, Wagener, Kenneth B., Williams, Kathryn R., Gaines, Taylor W.   +3 more
openaire   +4 more sources

Functional polymer materials containing heavy group‐14 elements focusing on germanium and tin

Smart Molecules, EarlyView.
The synthesis, functions, and applications of the polymers containing heavy group 14 elements focusing on germanium and tin are outlined. Owing to their large atomic radii and weak binding energies, the polymers show unique properties: chromism, luminescence, carrier mobility, and reactivity to produce radials and higher coordinated states.
Masayuki Gon, Kazuo Tanaka
wiley   +1 more source

Some remarks about the positivity of random variables on a Gaussian probability space [PDF]

, 2004
Let $(W,H,\mu)$ be an abstract Wiener space and $L$ be a probability density of class LlogL. Using the measure transportation of Monge-Kantorovitch, we prove that the kernel of the projection of L on the second Wiener chaos defines an (Hilbert-Schmidt ...
Feyel, D., Ustunel, A. S.
core   +3 more sources

Artificial intelligence streamlines scientific discovery of drug–target interactions

British Journal of Pharmacology, EarlyView.
Abstract Drug discovery is a complicated process through which new therapeutics are identified to prevent and treat specific diseases. Identification of drug–target interactions (DTIs) stands as a pivotal aspect within the realm of drug discovery and development. The traditional process of drug discovery, especially identification of DTIs, is marked by
Yuxin Yang, Feixiong Cheng
wiley   +1 more source

Transgenic Tobacco Plants Expressing Synthetic Peptides: A Functional and Structural Analysis for Pathogen Resistance

Plant Biotechnology Journal, EarlyView.
Peptide Power: VR18 & KG18 Shield Tobacco from Bacterial Attack. A schematic shows how antimicrobial peptides VR18 and KG18 fight Pseudomonas syringae—bursting bacterial membranes and boosting disease resistance in transgenic tobacco, without harming plant health.
Karishma Biswas, Sudipta Mitra, Dibakar Roy, Sanhita Roy, Dibakar Sarkar, DeokHyun Son, Rohit Das, Anuradha Roy, Dulal Senapati, Humaira Ilyas, A. Harikishore, Ranjit Biswas, Suman Chakrabarty, DongKuk Lee, Indranil Biswas, Sudipto Saha, Pallob Kundu, Anirban Bhunia   +17 more
wiley   +1 more source

Predicting the biological activity of selected phytochemicals in Alsophila spinulosa leaves against 4-aminobutyrate-aminotransferase: A potential antiepilepsy agents

Eclética Química
The use of medicinal plants as an alternative mean of treating various diseases has drawn the attention of several researchers. The desire to find lasting solutions to epilepsy among humans increases every day.
Oyebamiji Abel Kolawole, Olujinmi Faith Eniola, Akintelu Sunday Adewale, Adetuyi Babatunde, Ogunlana Olubanke, Semire Banjo, Akintayo Emmanuel Temitope, Akintayo Cecilia Olufunke, Babalola Jonathan Oyebamiji, Olawoye Bolanle Mary, Aworinde Juliana Oluwasayo   +10 more
doaj   +1 more source

Mycochemical Diversity and Therapeutic Potential of Hymenochaetoid Fungi from Central Asia: Regional and Global Perspectives

New Zealand Journal of Botany, Volume 64, Issue 1, March 2026.
Central Asia harbors a rich yet understudied assemblage of wood‐inhabiting Hymenochaetoid fungi. This review delivers the first comprehensive synthesis of 43 poroid species representing 18 genera documented across montane forests, steppes, and xeric habitats.
Yusufjon Gafforov, Milena Rašeta, Sylvie Rapior, Manzura Yarasheva, Oksana Mykchaylova, Rustamjon Allaberdiev, Şule İnci, Dilfuza Berdieva, Arshad Mehmood Abbasi, Shikhnazar Khodjaev, Dian‐Ming Hu, Weijun Yang, Abudujilili Abuduaini, Maria Letizia Taddei, Mengcen Wang, Islomjon Urinboev, Jiajia Chen   +16 more
wiley   +1 more source