Results 1 to 10 of about 2,370,277 (238)

Nanocrystals based pulmonary inhalation delivery system: advance and challenge

Drug Delivery, 2022
Pulmonary inhalation administration is an ideal approach to locally treat lung disease and to achieve systemic administration for other diseases. However, the complex nature of the structural characteristics of the lungs often results in the difficulty ...
Pengfei Yue, Weicheng Zhou, Guiting Huang, Fangfang Lei, Yingchong Chen, Zhilin Ma, Liru Chen, Ming Yang   +7 more
doaj   +2 more sources

Pharmacokinetics and central accumulation of delta-9-tetrahydrocannabinol (THC) and its bioactive metabolites are influenced by route of administration and sex in rats

Scientific Reports, 2021
Up to a third of North Americans report using cannabis in the prior month, most commonly through inhalation. Animal models that reflect human consumption are critical to study the impact of cannabis on brain and behaviour.
Samantha L. Baglot, Catherine Hume, Gavin N. Petrie, Robert J. Aukema, Savannah H. M. Lightfoot, Laine M. Grace, Ruokun Zhou, Linda Parker, Jong M. Rho, Stephanie L. Borgland, Ryan J. McLaughlin, Laurent Brechenmacher, Matthew N. Hill   +12 more
doaj   +2 more sources

Development and evaluation of a novel nebulized dihydromyricetin formulation: enhanced pulmonary delivery and pharmacokinetic properties [PDF]

Respiratory Research
Background Respiratory diseases are a major global health burden, and inhalation therapy offers efficient pulmonary targeting and therapeutic effectiveness.
Kunyan Xu, Jianing Yang, Meng Yan, Dan Li, Wenli Du, Jing Bai, Bai Xiang   +6 more
doaj   +2 more sources

A retrospective observational study on the efficacy of colistin by inhalation as compared to parenteral administration for the treatment of nosocomial pneumonia associated with multidrug-resistant Pseudomonas aeruginosa

BMC Infectious Diseases, 2011
Background Colistin is used as last treatment option for pneumonia associated with multidrug-resistant (MDR) Pseudomonas spp.. Literature about the best administration mode (inhalation versus parenteral treatment) is lacking.
Naesens Reinout, Vlieghe Erika, Verbrugghe Walter, Jorens Philippe, Ieven Margareta   +4 more
doaj   +2 more sources

Inhalatory and intravenous colistin in treating ventilator-associated pneumonia due to acinetobacter species: Should we combine them? [PDF]

Vojnosanitetski Pregled, 2020
Background/Aim. Acinetobacter is one of the most common causes of nosocomial infections, especially ventilatorassociated pneumonia (VAP). Considering the increased presence of multidrug-resistant microorganisms and the lack of novel antibiotics, colistin
Matijašević Jovan, Gavrilović Srđan, Andrijević Ilija, Andrijević Ana, Milić Svetislava, Vukoja Marija   +5 more
doaj   +1 more source

Nicotine e‐cigarette vapor inhalation and self‐administration in a rodent model: Sex‐ and nicotine delivery‐specific effects on metabolism and behavior

Addiction Biology, 2021
E‐cigarettes, which deliver vaporized nicotine, have dramatically risen in popularity in recent years, despite many unanswered questions about safety, efficacy in reducing dependence, and overall impact on public health.
V. Lallai, Yen-Chu Chen, Mikayla M Roybal, Eashan R Kotha, J. P. Fowler, Andres Staben, Angelique Cortez, C. Fowler   +7 more
semanticscholar   +1 more source

Therapeutic Potential of Mesenchymal Stem Cells and Their Products in Lung Diseases—Intravenous Administration versus Inhalation

Pharmaceutics, 2021
The number of publications studying the therapeutic use of stem cells has steadily increased since 2000. Compared to other applications, there has been little interest in the evaluation of mesenchymal stem cells (MSCs) and MSC-derived products (mostly ...
E. Fröhlich
semanticscholar   +1 more source

A mixed methods analysis of cannabis use routines for chronic pain management

Journal of Cannabis Research, 2022
Background The wide heterogeneity of available cannabis products makes it difficult for physicians to appropriately guide patients. In the current study, our objective was to characterize naturalistic cannabis use routines and explore associations ...
Kevin F. Boehnke, Laura Yakas, J. Ryan Scott, Melissa DeJonckheere, Evangelos Litinas, Suzanne Sisley, Daniel J. Clauw, David A. Williams, Jenna McAfee   +8 more
doaj   +1 more source

Inhalation delivery of dexamethasone with iSEND nanoparticles attenuates the COVID-19 cytokine storm in mice and nonhuman primates

Science Advances, 2023
Dexamethasone (DEX) is the first drug to show life-saving efficacy in patients with severe coronavirus disease 2019 (COVID-19), while DEX is associated with serious adverse effects.
Qian-Fang Meng, Wanbo Tai, Mingyao Tian, Xinyu Zhuang, Yuanwei Pan, Jialin Lai, Yangtao Xu, Zhiqiang Xu, Min Li, Guangyu Zhao, Guang-Tao Yu, Guocan Yu, Rongchang Chen, N. Jin, Xiao Li, G. Cheng, Xiaoyuan Chen, L. Rao   +17 more
semanticscholar   +1 more source

Inhaled turmerones can be incorporated in the organs via pathways different from oral administration and can affect weight-gain of mice

Scientific Reports, 2022
Turmerones (α-turmerone, β-turmerone, and ar-turmerone) are the major volatile compounds in turmeric (Curcuma longa), a perennial herb of the ginger family.
Yuki Takemoto, Chihiro Kishi, Hinano Ehira, Nobutaka Matsui, Taichi Yamaguchi, Yuri Yoshioka, Shinichi Matsumura, Tatsuya Moriyama, Nobuhiro Zaima   +8 more
doaj   +1 more source