Results 91 to 100 of about 96,743 (331)

Intranasal administration of probiotic Lactobacillus rhamnosus GG prevents birch pollen‐induced allergic asthma in a murine model

Allergy. European Journal of Allergy and Clinical Immunology, 2018
There is an increasing interest in targeted application of probiotic bacteria for prevention and treatment of airway diseases, including allergies.
Irina Spacova, Irina Spacova, M. Petrova, M. Petrova, A. Fremau, Lore Pollaris, Jeroen Vanoirbeek, Jan Ceuppens, S. Seys, Sarah Lebeer, Sarah Lebeer   +10 more
semanticscholar   +1 more source

Intranasal application of vasopressin fails to elicit changes in brain immediate early gene expression, neural activity and behavioral performance of rats [PDF]

, 2013
Intranasal administration has been widely used to investigate effects of the neuropeptides vasopressin and oxytocin on human behaviors and neurological disorders, but exactly what happens when these neuropeptides are administered intranasally is far from
Andreae, Appenrodt, Bales, Born, Chen, Churchland, Costa, Danguir, Dantzer, Denenberg, Dluzen, Donaldson, Engelmann, Engelmann, Engelmann, Ermisch, Fjellestad-Paulsen, Ganten, Giri, Goodson, Gouzenes, Graff, Guastella, Gutkowska, Hanson, Heinrichs, Hendricks, Hernando, Hoover, Huntingford, Insel, Ionescu, Jiang, Kandimalla, Kita, Klimkiewicz, Knopf, Landgraf, Landgraf, Levasseur, Lloyd, Ludwig, Lukas, Lund, MacDonald, Mens, Meyer-Lindenberg, Minn, Moal, Moal, Neumann, Newton, Noble, Olson, Paban, Petersson, Petty, Porges, Poulin, Ross, Sarkar, Seckl, Thorne, Thorne, Tobin, Wakerley, Wall, Watelet, Wied, Windle, Wioland, Young, Yu   +72 more
core   +1 more source

Structure‐Based Development of Ultra‐Broad‐Spectrum 3C‐Like Protease Inhibitors

Advanced Science, EarlyView.
This study provides an in‐depth analysis of the substrate binding pocket of 3CLpros across all coronavirus species using bioinformatics and structural insights, revealing the critical impact of S2/S4 subsite diversity on the broad‐spectrum activity of approved therapeutics.
Haixia Su, Tianqing Nie, Guofeng Chen, Muya Xiong, Yumin Zhang, Guoqing Wu, Mengyuan You, Hang Xie, Jian He, Yanchao Xiong, Hangchen Hu, Wenfeng Zhao, Minjun Li, Gengfu Xiao, Leike Zhang, Yechun Xu   +15 more
wiley   +1 more source

Design and Efficacy of Nanogels Formulations for Intranasal Administration

Molecules, 2018
Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer ...
B. Aderibigbe, T. Naki
semanticscholar   +1 more source

Recent Advances in Intranasal Liposomes for Drug, Gene, and Vaccine Delivery

Pharmaceutics, 2023
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles produced from cholesterol and phospholipids. Recently, liposomes have been widely administered intranasally for systemic and brain delivery. From the nasal cavity, liposome-
Van-An Duong, Thi-Thao-Linh Nguyen, H. Maeng   +2 more
semanticscholar   +1 more source

Administration of Nebulized Ketamine for Managing Acute Pain in the Emergency Department: A Case Series [PDF]

, 2020
Ketamine administration in sub-dissociative doses in the emergency department (ED) results in effective pain relief in patients with acute traumatic and non-traumatic pain, chronic pain, and opioid-tolerant pain.
Butt, Mahlaqa, Drapkin, Jefferson, Hossain, Rukhsana, Likourezos, Antonios, Masoudi, Aidin, Motov, Sergey   +5 more
core  

Bacterial outer membrane vesicles and vaccine applications [PDF]

, 2014
Vaccines based on outer membrane vesicles (OMV) were developed more than 20 years ago against Neisseria meningitidis serogroup B. These nano-sized structures exhibit remarkable potential for immunomodulation of immune responses and delivery of “self ...
Acevedo, Reinaldo, Acosta, Armando, Campa, Concepcion, Cardoso, Daniel, Fernandez, Sonsire, Ferro, Valerie, Garcia, Luis, Perez, Jose Luis, Rosenqvist, Einar, Sarmiento, Maria Elena, Zayas, Caridad   +10 more
core   +2 more sources

CD27 and ICOS as Targets of PD‐1/PD‐L1 Signaling to Regulate Resident Memory CD8+ T‐Cell‐Mediated Pulmonary Protection and Pathology

Advanced Science, EarlyView.
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Yuanyuan Chen, Zhenzhen Wang, Liqiang Song, Qianqian Chen, Hang Zhang, Tao Pan, Jianli Pan, Sheng Zhao, Ting Shang, Hong'en Xu, Xing Lv, Jing Li, Fei Kang, Yongzhan Nie, Feng Zhao, Lei Shi, Zheng Wang   +16 more
wiley   +1 more source

Spatial Profiling Reveals Distinct Molecular and Immune Evolution of Mouse Lung Adenocarcinoma Precancers with or Without Carcinogen Exposure

Advanced Science, EarlyView.
Tumor evolution in lung adenocarcinoma is shaped by genetic alterations and spatial immune dynamics. By integrating whole‐exome sequencing, imaging mass cytometry, and spatial transcriptomics across two mouse models, this study reveals how mutational burden, immune infiltration, and cell–state interactions evolve during early and late carcinogenesis ...
Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian‐Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao‐Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y. Liu, Beibei Huang, Frank R. Rojas, Parra Cuentas. Edwin Roger, Ou Shi, Monique B. Nilsson, Alissa Poteete, Khaja B. Khan, Wei Lu, Luisa M. Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I. Wistuba, Zhubo Wei, Linghua Wang, Don L. Gibbons, Ken Chen, Alexandre Reuben, Jason M. Schenke, John V. Heymach, Chao Cheng, Jia Wu, Jianjun Zhang   +34 more
wiley   +1 more source

Corticosteroids for the common cold [PDF]

, 2015
BACKGROUND: The common cold is a frequent illness, which, although benign and self limiting, results in many consultations to primary care and considerable loss of school or work days. Current symptomatic treatments have limited benefit.
Del Mar, Chris B., Glasziou, Paul P., Hayward, Gail, Heneghan, Carl J., Perera, Rafael, Thompson, Matthew J.   +5 more
core   +1 more source