From autism to eating disorders and more: the role of oxytocin in neuropsychiatric disorders [PDF]
, 2016 Oxytocin (oxy) is a pituitary neuropeptide hormone synthesized from the paraventricular and supraoptic nuclei within the hypothalamus. Like other neuropeptides, oxy can modulate a wide range of neurotransmitter and neuromodulator activities. Additionally,
Di Bonaventura, Maria Vittoria Micioni +3 more
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Study of embryotoxic effects of intranasally administred desloratadine on laboratory animals. [PDF]
Medičnì Perspektivi, 2017 The study was conducted to detect possible changes in embryogenesis and negative effects of third generation antihistamine – desloratadine – after intranasal administration of 1.3 mg/m3 and 13.0 mg/m3 of the substance to laboratory animals during their ...
Т. А. Alekhina +2 more
doaj +2 more sources
Scientific Reports, 2022 The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara +3 more
doaj +1 more source
A multicenter, open-label, long-term safety and tolerability study of DFN-02, an intranasal spray of sumatriptan 10 mg plus permeation enhancer DDM, for the acute treatment of episodic migraine. [PDF]
, 2017 BackgroundDFN-02 is a novel intranasal spray formulation composed of sumatriptan 10 mg and a permeation-enhancing excipient comprised of 0.2% 1-O-n-Dodecyl-β-D-Maltopyranoside (DDM).
Allenby, Kent +5 more
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Marketing research on intranasal medicines of domestic market
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2016 Modern development of biopharmaceutical research in world science and practice promotes the use of new dosage forms or administration routes of active substances in the human body.
B. S. Burlaka +2 more
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Intranasal administration of allergen increases specific IgE whereas intranasal omalizumab does not increase serum IgE levels : a pilot study [PDF]
, 2018 Background: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases in IgE antibody levels. Objective: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab ...
Bischoff +38 more
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Bioavailability of dexmedetomidine after intranasal administration
European Journal of Clinical Pharmacology, 2011 The aim of this proof-of-concept study was to characterize the pharmacokinetics and pharmacodynamics of intranasal dexmedetomidine compared with its intravenous administration in a small number of healthy volunteers.Single doses of 84 μg of dexmedetomidine were given once intravenously and once intranasally to seven healthy men.
Iirola, Timo +6 more
openaire +5 more sources
Electrocardiogram Assessment in Chough (Pyrrhocorax pyrrhocorax) Following Intranasal Administration of Anesthetics [PDF]
Iranian Journal of Veterinary Surgery, 2017 Objective- The objective of the present study was to define electrocardiographic data following intranasal administration of diazepam, midazolam and xylazine with or without Ketamine in Chough.Design- To determine the heart effects of anesthetics in ...
Majid Taati, Abbas Raisi
doaj +1 more source
Intranasal Administration for Pain: Oxytocin and Other Polypeptides [PDF]
Pharmaceutics, 2021 Pain, particularly chronic pain, remains one of the most debilitating and difficult-to-treat conditions in medicine. Chronic pain is difficult to treat, in part because it is associated with plastic changes in the peripheral and central nervous systems.
Vimala N. Bharadwaj +4 more
openaire +3 more sources
From clinical application to cognitive enhancement: the example of methylphenidate [PDF]
, 2016 Methylphenidate (MPD) is a central nervous system (CNS) stimulant, which belongs to the phenethylamine group and is mainly used in the treatment of attention deficit hyperactive disorder (ADHD).
Busardo', FRANCESCO PAOLO +4 more
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