Results 1 to 10 of about 13,775 (209)

Clinical efficacy of intravaginal recombinant lysostaphin administration on endometritis in sows [PDF]

Veterinary Medicine and Science, 2021
Recombinant lysostaphin has been used for the treatment of cow endometritis and mastitis in China. To our knowledge, no scientific effort has been made to evaluate the efficacy of lysostaphin in sows with clinical endometritis.
Guizi Ye, Jinjiang Huang, Guodong Li, Jien Zhang, Yongxue Sun, Dongping Zeng, Wenbin Bao, Jiang Zhong, Qingshan Huang   +8 more
doaj   +3 more sources

Introducing personalized patient care in overactive bladder management using the MedRing OAB system for intravaginal oxybutynin administration [PDF]

Drug Delivery
Although numerous drugs have been developed for intravaginal administration, the implementation of personalized intravaginal treatment options is limited.
S. I. Peltenburg, I. Koopmans, O. Heerema-Snoep, E. S. Klaassen, M. J. Juachon, A. Otten, N. B. Klarenbeek   +6 more
doaj   +2 more sources

Intravaginal administration of estradiol benzoate capsule for estrus synchronization in goats

The Journal of Reproduction and Development, 2021
Estrus synchronization requires multiple treatments of hormonal drugs, requiring considerable time and cost. The aim of the present study was to develop an estrus synchronization protocol using intravaginal administration of estradiol benzoate (EB ...
Sayaka MATSUMOTO, Tomomi TANAKA, Natsumi ENDO   +2 more
doaj   +4 more sources

Intravaginal delivery of mRNA-encoded antibodies with enhanced breadth and potency for SHIV/HIV protection [PDF]

Nature Communications
Broadly neutralizing antibodies (bnAbs) prevent HIV infection but face administration and cost challenges. We present single-chain mRNA-encoded bnAbs that improve heavy-light chain assembly and enable three enhancement approaches: co-expression, isotype ...
Jae Yeon Joo, Peng Xiao, Susan P. John, Daryll Vanover, Hannah E. Peck, Loren E. Sasser, Deepanwita Bose, Younghun Jung, Jaehyeon Hwang, Chiara Zurla, Francois Villinger, Philip J. Santangelo   +11 more
doaj   +2 more sources

Intra-vaginal gemcitabine-hybrid nanoparticles for effective cervical cancer treatment

OpenNano, 2022
Aim: This study aims to develop and evaluate hybrid nanoparticles for the effective intravaginal delivery of the anticancer gemcitabine in cervical cancer rat model.
Mona Elhabak, Samar Ibrahim, Reem R. Ibrahim   +2 more
doaj   +1 more source

First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring

Drug Delivery, 2023
Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereby avoiding ...
Willem de Laat, Lisa Pagan, R. Karl Malcolm, Maarten Wiegerinck, Victor Nickolson, Bertine Huisman, Rik Stuurman, Michiel van Esdonk, Naomi Klarenbeek   +8 more
doaj   +1 more source

Myo-inositol in the treatment of male factor infertility [PDF]

Гинекология, 2022
About 187 million couples worldwide suffer from infertility, with the male factor being diagnosed in 2070% of cases. The main cause of idiopathic infertility has been recognized as the adverse effects of reactive oxygen species.
Evgenia V. Shikh, Ludmila Yu. Grebenshikova, Olga V. Zhukova, Alina A. Bagdasaryan   +3 more
doaj   +1 more source

Comparison of Two Different Intervals of Misoprostol Administration in Second Trimester Abortions

Journal of Family and Reproductive Health, 2023
Objective: Comparison of two different intervals of misoprostol administration after mifepristone in second trimester abortions. Materials and methods: This 12-month prospective study was conducted at a tertiary care facility.
Anjali Gupta, Sarika Gautam, Shelly Chanana, Neetu Sangwan, Savita Rani Singhal, Smriti Anand, Sonia Dahiya   +6 more
doaj   +1 more source

Intravaginal administration of progesterone using a new technique for sustained drug release in goats

The Journal of Reproduction and Development, 2020
The objective of the present study was to develop and evaluate a sustained release vaginal progesterone (P4) capsule containing a mixture of mucoadhesive polymer and silicone fluid.
Natsumi ENDO, Larasati Puji RAHAYU, Takashi YAMAMURA, Hitoshi TANAKA, Tomomi TANAKA   +4 more
doaj   +1 more source

Evaluation of TLR agonists as potential mucosal adjuvants for HIV gp140 and tetanus toxoid in mice. [PDF]

PLoS ONE, 2012
In the present study we investigate the impact of a range of TLR ligands and chitosan as potential adjuvants for different routes of mucosal immunisation (sublingual (SL), intranasal (IN), intravaginal (IVag) and a parenteral route (subcutaneous (SC)) in
Viviana Buffa, Katja Klein, Lucia Fischetti, Robin J Shattock   +3 more
doaj   +1 more source