Results 151 to 160 of about 214,380 (250)

Targeting metabolic reprogramming to enhance adoptive immunotherapy: emerging mechanisms and translational perspectives. [PDF]

J Transl Med
Yang L, Zhang C, Zhang Z, Yao S, Shen J, Zhang Z, Xiao Z, Wang S, Wu Z.   +8 more
europepmc   +1 more source

CAR-Modified Vγ9Vδ2 T Cells Propagated Using a Novel Bisphosphonate Prodrug for Allogeneic Adoptive Immunotherapy. [PDF]

Int J Mol Sci, 2023
Wang Y, Wang L, Seo N, Okumura S, Hayashi T, Akahori Y, Fujiwara H, Amaishi Y, Okamoto S, Mineno J, Tanaka Y, Kato T, Shiku H.   +12 more
europepmc   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

T-cell Priming by High-Avidity Neoantigens in Lymph Nodes Augments Adoptive Immunotherapy. [PDF]

Cancer Immunol Res
Wittling MC, Rivera-Reyes AM, Wyatt MM, Cole AC, Smith AS, Rangel Rivera GO, Carmouche JH, Diatikar KG, Ruffin AT, Ware MB, Bennett FJ, Dwyer CJ, Pihl RMF, Kumaresan S, Lesinski GB, Paulos CM, Knochelmann HM.   +16 more
europepmc   +1 more source

Cytotoxicity of WT1-reactive T cells against Wilms tumor: An implication for antigen-specific adoptive immunotherapy. [PDF]

Bioimpacts, 2023
Monzavi SM, Hamidieh AA, Vasei M, Ai J, Ahmadbeigi N, Arshadi H, Muhammadnejad S, Kajbafzadeh AM.   +7 more
europepmc   +1 more source

Macrophage Trogocytosis of Tumor Cells Drives the Immunosuppression of Tumor Microenvironment

Advanced Science, EarlyView.
Trogocytosis efficiency varies significantly among different tumor cells and is inversely related to their cortical stiffness; this efficiency dictates the extent of immunosuppression via upregulation of CXCL5 and Arg‐1, ultimately driving CD8+T cell exhaustion and tumor escape.
Chao Liang, Jiaqi He, Wan‐Ru Zhuang, Yao Lei, Yanru Jiang, Xianbin Ma, Pan Liu, Zhujun Jiang, Yongheng Li, Hai‐Yan Xie   +9 more
wiley   +1 more source

PI3Kδ inhibition alters CD8 T cell differentiation and reprograms the tumor microenvironment following adoptive immunotherapy. [PDF]

J Immunol
Turnquist A, Javaid A, Wilkins OM, Kolling Iv F, Pioli PA, Paulos CM, Robert Frost H, Usherwood EJ.   +7 more
europepmc   +1 more source

Retracted: The Combined Clinical Efficacy and Safety Analysis of Adoptive Immunotherapy with Radiotherapy and Chemotherapy in Non-Small-Cell Lung Cancer: Systematic Review and Meta-Analysis. [PDF]

Appl Bionics Biomech, 2023
And Biomechanics AB.
europepmc   +1 more source

Radiation‐Triggered Chemokine‐Secreting Probiotics for Boron Neutron Capture Therapy Based Radioimmunotherapy

Advanced Science, EarlyView.
Engineered Escherichia coli Nissle 1917 with a tannic acid‐mediated BPA coating enables tumor‐targeted boron delivery for BNCT. The low‐level incidental radiation generated during BNCT activate a RecA‐driven circuit to induce CXCL10, while radiation‐enhanced bacterial colonization triggers in situ vaccination and systemic antitumor immunity.
Yang Liu, Yuzhong Qian, Shaobo Huang, Bingbing Li, Yue Yu, Xiang Cheng, Chang Chen, Jiheng Wang, Maosong Yang, Lizheng Liang, Xiancai Meng, Zhigang Liu   +11 more
wiley   +1 more source

Clinical Evaluation of Ex Vivo Expanded MUC1-Specific Peripheral Blood T Cells for Adoptive Immunotherapy in Relapsed/Refractory Multiple Myeloma. [PDF]

Cancer Res Commun
Meermeier EW, Missan DS, Pathangey LB, Stein CK, Reckard GA, Darvish SA, Ahmann GJ, Adamski J, Fonseca R, Gendler SJ, Gustafson MP, Bergsagel PL.   +11 more
europepmc   +1 more source