Results 191 to 200 of about 306,104 (338)

Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy

Cell Reports
Summary: Adoptive cell therapies are emerging forms of immunotherapy that reprogram T cells for enhanced antitumor responses. Although surface programmed cell death-ligand 1 (PD-L1)/programmed cell death protein 1 (PD-1) engagement inhibits antitumor ...
Xinran Wang, Lu Lu, Xiaochuan Hong, Lingling Wu, Chao Yang, You Wang, Wenwen Li, Yuanqin Yang, Dongqing Cao, Wen Di, Liufu Deng   +10 more
doaj  

Can Adoptive Immunotherapy With Hepatitis E Virus (HEV)-Specific T Cells Address the Unmet Need in Refractory Chronic HEV Infection? [PDF]

Open Forum Infect Dis
Lampejo T.
europepmc   +1 more source

Combined PD-L1 and TIM3 blockade improves expansion of fit human CD8⁺ antigen-specific T cells for adoptive immunotherapy. [PDF]

Mol Ther Methods Clin Dev, 2022
Lak S, Janelle V, Djedid A, Boudreau G, Brasey A, Lisi V, Smaani A, Carli C, Busque L, Lavallée VP, Delisle JS.   +10 more
europepmc   +1 more source

Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma

Molecular Therapy: Methods & Clinical Development, 2018
Zhongzhen Yi, Brooke Prinzing, Felicia Cao, S. Gottschalk, Giedre Krenciute   +4 more
semanticscholar   +1 more source

Bispecific Antibody Targeting VEGF/TGF‐β Synergizes with Local Radiotherapy: Turning Tumors from Cold to Inflamed and Amplifying Abscopal Effects

Advanced Science, EarlyView.
Y332D, a bispecific antibody that simultaneously blockades VEGF and TGF‐β, counteracted negative RT effects that are attributed to the upregulation of TGF‐β and VEGF, as well as further enhanced the immunostimulatory effects of RT, thereby reprograming the TME from immune “cold” to inflamed state and forming an effective in‐situ vaccine that eradicate ...
Lijuan Lyu, Ming Yi, Ji Chen, Jing Zhang, Xiaobin Ma, Xiaojun Zhang, Liang Zeng, Yan Xue, Haimei Wen, Yujiao Deng, Pengfei Zhou, Kongming Wu, Huafeng Kang, Zhijun Dai   +13 more
wiley   +1 more source

Adoptive immunotherapy of murine CML: navigating between Scylla and Charybdis [PDF]

, 2004
Michael W. Deininger
openalex   +1 more source

Compassionate access to virus-specific T cells for adoptive immunotherapy over 15 years. [PDF]

Nat Commun
Neller MA, Ambalathingal GR, Hamad N, Sasadeusz J, Pearson R, Holmes-Liew CL, Singhal D, Tunbridge M, Ng WY, Sharplin K, Moore A, Deambrosis D, Soosay-Raj T, McNaughton P, Whyte M, Fraser C, Grigg A, Kliman D, Bajel A, Cummins K, Dowling M, Yeoh ZH, Harrison SJ, Khot A, Tan S, Roos I, Koo RM, Dohrmann S, Ritchie D, Wainstein B, McCleary K, Nelson A, Gardiner B, Inam S, Badoux X, Ma K, Toro C, Hanna D, Hughes D, Conyers R, Cole T, Wang SS, Chee L, Fleming J, Irish A, Purtill D, Cooney J, Shaw P, Tey SK, Hunt S, Subramonia Pillai E, John G, Ng M, Ramachandran S, Hopkins P, Chambers D, Campbell S, Francis R, Isbel N, Marlton P, Reddiex H, Matthews KK, Voogt M, Panikkar A, Beagley L, Rehan S, Best S, Raju J, Le Texier L, Crooks P, Solomon M, Lekieffre L, Srihari S, Smith C, Khanna R.   +74 more
europepmc   +1 more source

Erratum: Adoptive immunotherapy for gastric cancer using zoledronate-activated killer cells: A prospective observational study. [PDF]

Mol Clin Oncol, 2022
Yamaguchi Y, Katata Y, Sano F, Tanioka H, Okawaki M, Yamamura M, Nagasaka T.   +6 more
europepmc   +1 more source

Targeting Glutamine Metabolism Transporter SLC25A22 Enhances CD8+ T‐Cell Function and Anti‐PD‐1 Therapy Efficacy in Cervical Squamous Cell Carcinoma: Integrated Metabolomics, Transcriptomics and T‐Cell‐Incorporated Tumor Organoid Studies

Advanced Science, EarlyView.
Through metabolomic and transcriptomic analyses, a glutamine‐enriched, immunosuppressive microenvironment is identified in cervical squamous cell carcinoma (CSCC), highlighting the glutamine transporter SLC25A22 as a key regulator of glutamine metabolism, immune checkpoint activation, and CD8+ T‐cell cytotoxicity.
Tingting Ren, Junjun Qiu, Fanghua Chen, Qian Jiang, Qinqin Liu, Tong Wu, Hua Jiang, Keqin Hua   +7 more
wiley   +1 more source

Acute myeloid leukaemia cells secrete a soluble factor that inhibits T and NK cell proliferation but not cytolytic function – implications for the adoptive immunotherapy of leukaemia

, 2001
J. K. Orleans‐Lindsay, L D Barber, H. G. Prentice, Mark W. Lowdell   +3 more
openalex   +2 more sources