Results 1 to 10 of about 63,665 (250)
Immune cell labelling and tracking: implications for adoptive cell transfer therapies [PDF]
EJNMMI Radiopharmacy and Chemistry, 2021 Background The understanding of the role of different immune cell subsets that infiltrate tumors can help researchers in developing new targeted immunotherapies to reactivate or reprogram them against cancer.
Filippo Galli +5 more
doaj +5 more sources
Frontiers in Immunology, 2021 During the last decade, many studies have demonstrated the role of CMV specific T-cell immune response on controlling CMV replication and dissemination. In fact, it is well established that transplanted patients lacking CMV-specific T-cell immunity have ...
Estéfani García-Ríos +3 more
doaj +3 more sources
Anti-tumor efficacy of a combination therapy with PD-L1 targeted alpha therapy and adoptive cell transfer of PD-1 deficient melanoma-specific human T-lymphocytes [PDF]
OncoImmunology, 2021 The optimization of adoptive transfer approaches of anti-tumor T cells requires both the functional improvement of the injected T cells and the modulation of the tumor microenvironment, favoring the recruitment of these T cells and their activation.
L Marotte +13 more
doaj +2 more sources
Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells. [PDF]
PLoS ONE, 2015 We previously described that in a rat model of heart transplantation tolerance was dependent on CD8+CD45RClow Tregs that over-expressed fibrinogen-like protein 2 (FGL2)/fibroleukin. Little is known on the immunoregulatory properties of FGL2.
Séverine Bézie +10 more
doaj +1 more source
Adoptive Cell Transfer Therapy [PDF]
Seminars in Oncology, 2007 Adoptive cell transfer therapy has developed into a potent and effective treatment for patients with metastatic melanoma. Current application of this therapy relies on the ex vivo generation of highly active, highly avid tumor-reactive lymphocyte cultures from endogenous tumor infiltrating lymphocytes or on the genetic engineering of cells using ...
Mark E, Dudley, Steven A, Rosenberg
openaire +2 more sources
Adoptive transfer of induced-Treg cells effectively attenuates murine airway allergic inflammation. [PDF]
PLoS ONE, 2012 Both nature and induced regulatory T (Treg) lymphocytes are potent regulators of autoimmune and allergic disorders. Defects in endogenous Treg cells have been reported in patients with allergic asthma, suggesting that disrupted Treg cell-mediated ...
Wei Xu +14 more
doaj +1 more source
A novel and effective cancer immunotherapy mouse model using antigen-specific B cells selected in vitro. [PDF]
PLoS ONE, 2014 Immunotherapies such as adoptive transfer of T cells or natural killer cells, or monoclonal antibody (MoAb) treatment have recently been recognized as effective means to treat cancer patients.
Tatsuya Moutai +3 more
doaj +1 more source
Adoptive Transfer of Memory B Cells [PDF]
BIO-PROTOCOL, 2015 The adoptive transfer of antigen-specific B cells into mice that cannot recognize that specific antigen has two main advantages. The first is determining exactly when the B cells were transferred and exposed to antigen. The second is that all B cells that can bind that antigen are the ones that were transferred; no new antigen-specific B cells will ...
Griselda Zuccarino-Catania +1 more
openaire +3 more sources
Frontiers in Immunology, 2023 Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic
Vianca V. Vianzon +4 more
doaj +1 more source
Impact of interleukin-7 on the differentiation and anti-tumor capabilities of CD8+ T cells [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2020 Background: Developing optimal strategies for generating T cells capable of effectively controlling tumors is one of the most important prerequisites for the clinical application of adoptive cell therapies in cancer patients.
Abdelaziz Zidan, Muobarak Tuorkey
doaj +1 more source