Adoptive cell transfer therapy for hepatocellular carcinoma [PDF]
Frontiers of Medicine, 2019 Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed.
Renyu, Zhang +6 more
openaire +2 more sources
Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. [PDF]
PLoS ONE, 2012 Adoptive T cell therapy has proven to be beneficial in a number of tumor systems by targeting the relevant tumor antigen. The tumor antigen targeted in our model is Mammaglobin-A, expressed by approximately 80% of human breast tumors.
Nadine M Lerret +3 more
doaj +1 more source
Focus on Adoptive T Cell Transfer Trials in Melanoma
Clinical and Developmental Immunology, 2010 Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%–70% of the patients.
Liat Hershkovitz +3 more
doaj +1 more source
Adoptive Cell Transfer in the Treatment of Metastatic Melanoma [PDF]
Journal of Investigative Dermatology, 2009 Adoptive cell therapy (ACT) for metastatic cancer is the focus of considerable research effort. Rosenberg's laboratory demonstrated a 50% response rate in stage IV melanoma patients treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) and high-dose IL-2 administered after nonmyeloablative conditioning (Dudley et al., 2002a).
Straten, Per thor, Becker, Jürgen C
openaire +3 more sources
Natural Killer Cell-Mediated Cellular Therapy of Hematological Malignancies
Clinical Hematology International, 2019 Our understanding on the mechanisms of graft versus tumor/leukemia (GvT/GvL) and graft versus host (GvH) effects has tremendously evolved within the past decades.
Ugur Sahin, Meral Beksac
doaj +1 more source
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]
PLoS ONE, 2018 Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye +6 more
doaj +1 more source
OncoImmunology, 2012 During the last two decades, several approaches for the activation of the immune system against cancer have been developed. These include rather unselective maneuvers such as the systemic administration of immunostimulatory agents (e.g., interleukin-2) as well as targeted interventions, encompassing highly specific monoclonal antibodies, vaccines and ...
Galluzzi, Lorenzo +8 more
openaire +2 more sources
Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies
Frontiers in Immunology, 2013 Recent early-stage clinical trials evaluating the adoptive transfer of patient CD8+ T-cells re-directed with antigen receptors recognising tumours have shown very encouraging results.
Angharad eLloyd +2 more
doaj +1 more source
Anti-telomerase T cells adoptive transfer
Aging, 2017 Commentary on the application of TERT-specific T cell adoptive cell therapy for cancer ...
De Sanctis, Francesco +2 more
openaire +2 more sources
Adoptive Transfer of Lung Antigen Presenting Cells
BIO-PROTOCOL, 2017 Our protocol describes adoptive transfer of antigen presenting cells (APCs) isolated from the lungs by enzymatic digestion and magnetic enrichment. This protocol can be used to study APC functions and trafficking.
Xiaofeng Zhou, Bethany Moore
openaire +4 more sources