Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis
American Journal of Respiratory Cell and Molecular Biology, 2020 Abstract Patients with lymphangioleiomyomatosis (LAM) develop pulmonary cysts associated with neoplastic, smooth muscle–like cells that feature neuroendocrine cell markers. The disease preferentially affects premenopausal women. Existing therapeutics do not cure LAM.
Fei Han +10 more
openaire +3 more sources
OncoImmunology, 2012 During the last two decades, several approaches for the activation of the immune system against cancer have been developed. These include rather unselective maneuvers such as the systemic administration of immunostimulatory agents (e.g., interleukin-2) as well as targeted interventions, encompassing highly specific monoclonal antibodies, vaccines and ...
Galluzzi, Lorenzo +8 more
openaire +2 more sources
Natural Killer Cell-Mediated Cellular Therapy of Hematological Malignancies
Clinical Hematology International, 2019 Our understanding on the mechanisms of graft versus tumor/leukemia (GvT/GvL) and graft versus host (GvH) effects has tremendously evolved within the past decades.
Ugur Sahin, Meral Beksac
doaj +1 more source
Inhibiting TGF-beta signaling preserves the function of highly activated, in vitro expanded natural killer cells in AML and colon cancer models. [PDF]
PLoS ONE, 2018 Natural killer cells harnessed from healthy individuals can be expanded ex vivo using various platforms to produce large doses for adoptive transfer into cancer patients.
Folashade Otegbeye +6 more
doaj +1 more source
Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies
Frontiers in Immunology, 2013 Recent early-stage clinical trials evaluating the adoptive transfer of patient CD8+ T-cells re-directed with antigen receptors recognising tumours have shown very encouraging results.
Angharad eLloyd +2 more
doaj +1 more source
Anti-telomerase T cells adoptive transfer
Aging, 2017 Commentary on the application of TERT-specific T cell adoptive cell therapy for cancer ...
De Sanctis, Francesco +2 more
openaire +2 more sources
Enhanced neointima formation following arterial injury in immune deficient Rag-1-/- mice is attenuated by adoptive transfer of CD8 T cells. [PDF]
PLoS ONE, 2011 T cells modulate neointima formation after arterial injury but the specific T cell population that is activated in response to arterial injury remains unknown.
Paul C Dimayuga +7 more
doaj +1 more source
MAIT Cell Adoptive Transfer v1 [PDF]
, 2020 This is part 3.2 of the "Study of MAIT Cell Activation in Viral Infections In Vivo" collection of protocols. Collection Abstract: MAIT cells are abundant, highly evolutionarily conserved innate-like lymphocytes expressing a semi-invariant T cell receptor (TCR), which recognizes microbially derived small intermediate molecules from the riboflavin ...
Timothy S C Hinks +7 more
openaire +1 more source
Frontiers in ImmunologyInvariant natural killer T (iNKT) cells are a small subset of T lymphocytes that release large amounts of cytokines such as IFN-γ and exhibit cytotoxic activity upon activation, inducing strong anti-tumor effects.
Mariko Takami, Shinichiro Motohashi
doaj +1 more source
CD8+ DC, but Not CD8(-)DC, isolated from BCG-infected mice reduces pathological reactions induced by mycobacterial challenge infection. [PDF]
PLoS ONE, 2010 Tuberculosis is a mycobacterial infection causing worldwide public health problems but the available vaccine is far from ideal. Type-1 T cell immunity has been shown to be critical for host defence against tuberculosis infection, but the role of ...
Xiaoling Gao +5 more
doaj +1 more source