Results 51 to 60 of about 65,713 (156)

Ablation of T cell–associated PD-1H enhances functionality and promotes adoptive immunotherapy

JCI Insight, 2022
Programmed death-1 homolog (PD-1H) is a coinhibitory molecule that negatively regulates T cell–mediated immune responses. In this study, we determined whether ablation of T cell–associated PD-1H could enhance adoptive T cell therapy in experimental tumor
Li Hu, Ling Chen, Zexiu Xiao, Xu Zheng, Yuangui Chen, Na Xian, Christina Cho, Liqun Luo, Gangxiong Huang, Lieping Chen   +9 more
doaj   +1 more source

Prospects for combined use of oncolytic viruses and CAR T-cells

Journal for ImmunoTherapy of Cancer, 2017
With the approval of talimogene laherparepvec (T-VEC) for inoperable locally advanced or metastatic malignant melanoma in the USA and Europe, oncolytic virotherapy is now emerging as a viable therapeutic option for cancer patients. In parallel, following
Adam Ajina, John Maher
doaj   +1 more source

The adoptive transfer of BCG-induced T lymphocytes contributes to hippocampal cell proliferation and tempers anxiety-like behavior in immune deficient mice.

PLoS ONE, 2020
We previously have reported that neonatal Bacillus Calmette-Guerin (BCG) vaccination improves neurogenesis and behavior in early life through affecting the neuroimmune milieu in the brain, but it is uncertain whether activation phenotypes and functional ...
Dan Song, Fangfang Qi, ShuaiShuai Liu, Zhongsheng Tang, Jinhai Duan, Zhibin Yao   +5 more
doaj   +1 more source

Prospectives of T-cells genetic programming in adoptive immunotherapy of malignancies

Сеченовский вестник, 2016
The article reviews the literature on adoptive T-cell therapy of malignancies. Adoptive T-cell transfer allows treatment of metastatic disease on the late stages of certain tumors.
O. L. Morozova, V. V. Yakovlev, N. A. Sushentsev   +2 more
doaj  

CMV-specific CD8 T Cell Differentiation and Localization: Implications for Adoptive Therapies

Frontiers in Immunology, 2016
Human cytomegalovirus (HCMV) is a ubiquitous virus that causes chronic infection, and thus is one of the most common infectious complications of immune suppression.
Corinne J Smith, Michael Quinn, Christopher M. Snyder   +2 more
doaj   +1 more source

Reenergized Adoptive Cell Transfer Immunotherapy

The FASEB Journal, 2018
Immunotherapy, in treating solid tumors, has seen increased efficacy due to the development of novel strategies of implementation. One innovative strategy, in development by Dr. Weiguo Cui and his colleagues, combines adoptive cell transfer (ACT) with pathogen‐based vaccine techniques in what is called Reenergized ACT (ReACT).
Carl Kaiser, Keith Klestinski, Weiguo Cui, Mika Chang, Nelson Cowan, Sean Smith, Daniel Strom, James Strom   +7 more
openaire   +1 more source

Trial Watch: Adoptive cell transfer for oncological indications [PDF]

OncoImmunology, 2015
One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of appropriate expansion, activation and targeting protocols), and re-infused into lymphodepleted patients
Fernando, Aranda, Aitziber, Buqué, Norma, Bloy, Francesca, Castoldi, Alexander, Eggermont, Isabelle, Cremer, Wolf Hervé, Fridman, Jitka, Fucikova, Jérôme, Galon, Radek, Spisek, Eric, Tartour, Laurence, Zitvogel, Guido, Kroemer, Lorenzo, Galluzzi   +13 more
openaire   +2 more sources

The potential and promise for clinical application of adoptive T cell therapy in cancer

Journal of Translational Medicine
Adoptive cell therapy has revolutionized cancer treatment, especially for hematologic malignancies. T cells are the most extensively utilized cells in adoptive cell therapy.
Yinqi Li, Yeteng Zheng, Taiqing Liu, Chuanyun Liao, Guobo Shen, Zhiyao He   +5 more
doaj   +1 more source

New directions in cellular therapy of cancer: a summary of the summit on cellular therapy for cancer

Journal of Translational Medicine, 2012
A summit on cellular therapy for cancer discussed and presented advances related to the use of adoptive cellular therapy for melanoma and other cancers. The summit revealed that this field is advancing rapidly.
Stroncek David F, Berger Carolina, Cheever Martin A, Childs Richard W, Dudley Mark E, Flynn Peter, Gattinoni Luca, Heath James R, Kalos Michael, Marincola Francesco M, Miller Jeffrey S, Mostoslavsky Gustavo, Powell Daniel J, Rao Mahendra, Restifo Nicholas P, Rosenberg Steven A, O'Shea John, Melief Cornelis JM   +17 more
doaj   +1 more source

Functional genomics for improving adoptive T-cell transfer therapies

Journal for ImmunoTherapy of Cancer
Adoptive cell therapy (ACT) has shown remarkable success in the treatment of some malignancies, particularly leukemia. However, there are multiple factors that limit the durability of ACT in solid tumors, including dose-limiting toxicities, the ...
Saad S Kenderian, Ingunn M Stromnes, Alexander K Tsai, Joseph G Skeate, Branden S Moriarity, David A Largaespada, Chang-Jung Lee, Laura M Rogers, Carli Stewart, Mathew J Fischbach, Bibekananda Kar   +10 more
doaj   +1 more source