Results 41 to 50 of about 65,713 (156)
Adoptive Transfer of Lung Antigen Presenting Cells
BIO-PROTOCOL, 2017 Our protocol describes adoptive transfer of antigen presenting cells (APCs) isolated from the lungs by enzymatic digestion and magnetic enrichment. This protocol can be used to study APC functions and trafficking.
Xiaofeng Zhou, Bethany Moore
openaire +4 more sources
Frontiers in ImmunologyRegulatory T cells (Tregs) play a central role in maintaining immune homeostasis. Therefore, owing to their unique immunomodulatory function, their adoptive transfer has been investigated as a novel therapeutic modality.
Yohei Sato, Yohei Sato, Yohei Sato
doaj +1 more source
Development of allogeneic NK cell adoptive transfer therapy in metastatic melanoma patients: in vitro preclinical optimization studies. [PDF]
PLoS ONE, 2013 Natural killer (NK) cells have long been considered as potential agents for adoptive cell therapy for solid cancer patients. Until today most studies utilized autologous NK cells and yielded disappointing results.
Michal J Besser +9 more
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Adoptive cell transfer as personalized immunotherapy for human cancer [PDF]
Science, 2015 Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to ...
Steven A, Rosenberg, Nicholas P, Restifo
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Cell Communication and Signaling, 2023 Androgen deprivation therapy (ADT) is a standard therapy for prostate cancer (PCa). Though disseminated disease is initially sensitive to ADT, an important fraction of the patients progresses to castration-resistant prostate cancer (CRPC).
Rydell Alvarez-Arzola +10 more
doaj +1 more source
Viruses, 2021 The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress the human immunodeficiency virus (HIV) infection.
Mohammad Haque +8 more
doaj +1 more source
Trial Watch: Adoptively transferred cells for anticancer immunotherapy [PDF]
OncoImmunology, 2017 Immunotherapies aimed at strengthening immune effector responses against malignant cells are growing at exponential rates. Alongside, the impressive benefits obtained by patients with advanced melanoma who received adoptively transferred tumor-infiltrating lymphocytes (TILs) have encouraged the scientific community to pursue adoptive cell transfer (ACT)
Fournier, Carole +5 more
openaire +4 more sources
Effect of adoptive transfer or depletion of regulatory T cells on triptolide-induced liver injury
Frontiers in Pharmacology, 2016 ObjectiveThe aim of this study is to clarify the role of regulatory T cell (Treg) in triptolide (TP)-induced hepatotoxicity. MethodsFemale C57BL/6 mice received either adoptive transfer of Tregs or depletion of Tregs, then underwent TP administration and
Xinzhi eWang +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Peripheral T-cell lymphoma (PTCL) is a type of highly heterogeneous non-Hodgkin lymphoma with a poor prognosis and lack of effective targeted therapies. Adoptive T-cell therapy has been successfully used in the treatment of B-cell malignancies.
Yuan Chen +6 more
doaj +1 more source
Frontiers in Immunology, 2018 CPT-11 is a first-line chemotherapeutic agent for the treatment of colorectal cancer in clinic. Previous studies including ours have demonstrated that CPT-11 is, however, toxic to the intestinal epithelium and resident peritoneal macrophages.
Wen-Jing Bai +8 more
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