Results 21 to 30 of about 65,713 (156)
Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. [PDF]
Proc Natl Acad Sci U S A, 2017 Xin G +6 more
europepmc +2 more sources
Treatment of lymphoma with adoptively transferred T cells [PDF]
Expert Opinion on Biological Therapy, 2009 Chemotherapy-resistant lymphomas can be cured with allogeneic hematopoietic cell transplantation, demonstrating the susceptibility of these tumors to T cell mediated immune responses. However, high rates of transplant-related morbidity and mortality limit this approach.
Brian G, Till, Oliver W, Press
openaire +2 more sources
High-affinity T cell receptors for adoptive cell transfer. [PDF]
J Clin Invest, 2019 Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al.
Isser A, Schneck JP.
europepmc +4 more sources
ADOPTIVE CELL THERAPY: CURRENT ADVANCES
Южно-Российский онкологический журнал, 2020 The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT).
T. V. Shamova +3 more
doaj +1 more source
TARGETING TUMOURS BY ADOPTIVE TRANSFER OF IMMUNE CELLS [PDF]
Clinical and Experimental Pharmacology and Physiology, 2006 1. Surgery, radiotherapy and chemotherapy are the most widely used and well-established modalities for treating malignant diseases. Surgery is used to excise solid tumours and radiotherapy/chemotherapy are used for the treatment of liquid tumours and for solid tumours where there is a risk of micrometastases.
P A, Macary, C T, Too, X, Dai
openaire +2 more sources
Journal of Hematology & Oncology, 2019 Background Allogeneic hematopoietic stem cell transplantation (HSCT) can expose patients to a transient but marked immunosuppression, during which viral infections are an important cause of morbidity and mortality.
Theresa Kaeuferle +4 more
doaj +1 more source
Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes
Journal for ImmunoTherapy of Cancer, 2020 Background Genome editing offers unique perspectives for optimizing the functional properties of T cells for adoptive cell transfer purposes. So far, PDCD1 editing has been successfully tested mainly in chimeric antigen receptor T (CAR-T) cells and human
Nathalie Labarrière +17 more
doaj +1 more source
Adoptive cell transfer therapy for hepatocellular carcinoma [PDF]
Frontiers of Medicine, 2019 Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This malignancy is associated with poor prognosis and high mortality. Novel approaches for prolonging the overall survival of patients with advanced HCC are urgently needed.
Renyu, Zhang +6 more
openaire +2 more sources
Adoptive transfer of Mammaglobin-A epitope specific CD8 T cells combined with a single low dose of total body irradiation eradicates breast tumors. [PDF]
PLoS ONE, 2012 Adoptive T cell therapy has proven to be beneficial in a number of tumor systems by targeting the relevant tumor antigen. The tumor antigen targeted in our model is Mammaglobin-A, expressed by approximately 80% of human breast tumors.
Nadine M Lerret +3 more
doaj +1 more source
Focus on Adoptive T Cell Transfer Trials in Melanoma
Clinical and Developmental Immunology, 2010 Adoptive Cell Transfer (ACT) of Tumor-Infiltrating Lymphocytes (TIL) in combination with lymphodepletion has proven to be an effective treatment for metastatic melanoma patients, with an objective response rate in 50%–70% of the patients.
Liat Hershkovitz +3 more
doaj +1 more source