Improving Tumor Retention of Effector Cells in Adoptive Cell Transfer Therapies by Magnetic Targeting [PDF]
Pharmaceutics, 2020 Adoptive cell transfer therapy is a promising anti-tumor immunotherapy in which effector immune cells are transferred to patients to treat tumors. However, one of its main limitations is the inefficient trafficking of inoculated effector cells to the ...
Laura Sanz-Ortega +2 more
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Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis
American Journal of Respiratory Cell and Molecular Biology, 2020 Abstract Patients with lymphangioleiomyomatosis (LAM) develop pulmonary cysts associated with neoplastic, smooth muscle–like cells that feature neuroendocrine cell markers. The disease preferentially affects premenopausal women. Existing therapeutics do not cure LAM.
Fei Han +10 more
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Metabolic radiolabeling and in vivo PET imaging of cytotoxic T lymphocytes to guide combination adoptive cell transfer cancer therapy [PDF]
Journal of Nanobiotechnology, 2021 Background Adoptive T cell transfer-based immunotherapy yields unsatisfactory results in the treatment of solid tumors, partially owing to limited tumor infiltration and the immunosuppressive microenvironment in solid tumors.
Dehua Lu +8 more
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High-affinity T cell receptors for adoptive cell transfer [PDF]
Journal of Clinical Investigation, 2018 Adoptive cell transfer (ACT) of engineered T cell receptors (TCRs) for cancer immunotherapy has evolved from simple gene transfer of isolated TCRs to various affinity enhancement techniques that overcome limitations imposed by central and peripheral tolerance on TCR affinity. In the current issue of the JCI, Poncette et al.
Ariel, Isser, Jonathan P, Schneck
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Adoptive cell transfer: new perspective treatment in veterinary oncology [PDF]
Acta Veterinaria Scandinavica, 2018 Cancer immunotherapy is recently considered the most promising treatment for human patients with advanced tumors and could be effectively combined with conventional therapies such as chemotherapy or radiotherapy.
Joanna Katarzyna Bujak +3 more
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Enhancing Adoptive Cell Transfer with Combination BRAF-MEK and CDK4/6 Inhibitors in Melanoma. [PDF]
Cancers (Basel), 2021 Lau PKH +11 more
europepmc +2 more sources
Adoptive cell transfer as personalized immunotherapy for human cancer [PDF]
Science, 2015 Adoptive cell therapy (ACT) is a highly personalized cancer therapy that involves administration to the cancer-bearing host of immune cells with direct anticancer activity. ACT using naturally occurring tumor-reactive lymphocytes has mediated durable, complete regressions in patients with melanoma, probably by targeting somatic mutations exclusive to ...
Steven A, Rosenberg, Nicholas P, Restifo
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Trial Watch: Adoptive cell transfer for oncological indications [PDF]
OncoImmunology, 2015 One particular paradigm of anticancer immunotherapy relies on the administration of (potentially) tumor-reactive immune effector cells. Generally, these cells are obtained from autologous peripheral blood lymphocytes (PBLs) ex vivo (in the context of appropriate expansion, activation and targeting protocols), and re-infused into lymphodepleted patients
Fernando, Aranda +13 more
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Adoptive Cell Transfer of Regulatory T Cells Exacerbates Hepatic Steatosis in High-Fat High-Fructose Diet-Fed Mice. [PDF]
Front Immunol, 2020 Van Herck MA +9 more
europepmc +2 more sources
Pathogen boosted adoptive cell transfer immunotherapy to treat solid tumors. [PDF]
Proc Natl Acad Sci U S A, 2017 Xin G +6 more
europepmc +2 more sources