Results 11 to 20 of about 65,713 (156)
Adoptive Cell Transfer Therapy [PDF]
Seminars in Oncology, 2007 Adoptive cell transfer therapy has developed into a potent and effective treatment for patients with metastatic melanoma. Current application of this therapy relies on the ex vivo generation of highly active, highly avid tumor-reactive lymphocyte cultures from endogenous tumor infiltrating lymphocytes or on the genetic engineering of cells using ...
Mark E, Dudley, Steven A, Rosenberg
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Adoptive Transfer of Memory B Cells [PDF]
BIO-PROTOCOL, 2015 The adoptive transfer of antigen-specific B cells into mice that cannot recognize that specific antigen has two main advantages. The first is determining exactly when the B cells were transferred and exposed to antigen. The second is that all B cells that can bind that antigen are the ones that were transferred; no new antigen-specific B cells will ...
Griselda Zuccarino-Catania +1 more
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Frontiers in Immunology, 2023 Efficient intratumoral infiltration of adoptively transferred cells is a significant barrier to effectively treating solid tumors with adoptive cellular transfer (ACT) therapies. Our recent forward genetic, whole-genome screen identified T cell-intrinsic
Vianca V. Vianzon +4 more
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Adoptive cell transfer using autologous tumor infiltrating lymphocytes in gynecologic malignancies. [PDF]
Gynecol Oncol, 2018 Mayor P, Starbuck K, Zsiros E.
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Impact of interleukin-7 on the differentiation and anti-tumor capabilities of CD8+ T cells [PDF]
Egyptian Journal of Cancer and Biomedical Research, 2020 Background: Developing optimal strategies for generating T cells capable of effectively controlling tumors is one of the most important prerequisites for the clinical application of adoptive cell therapies in cancer patients.
Abdelaziz Zidan, Muobarak Tuorkey
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Adoptive Cell Transfer in the Treatment of Metastatic Melanoma [PDF]
Journal of Investigative Dermatology, 2009 Adoptive cell therapy (ACT) for metastatic cancer is the focus of considerable research effort. Rosenberg's laboratory demonstrated a 50% response rate in stage IV melanoma patients treated with in vitro expanded tumor-infiltrating lymphocytes (TILs) and high-dose IL-2 administered after nonmyeloablative conditioning (Dudley et al., 2002a).
Straten, Per thor, Becker, Jürgen C
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Adoptive Immunotherapy Based on Chain-Centric TCRs in Treatment of Infectious Diseases
iScience, 2020 Summary: Complications after vaccination, lack of vaccines against certain infections, and the emergence of antibiotic-resistant microorganisms point to the need for alternative ways of protection and treatment of infectious diseases. Here, we proposed a
Anastasiia A. Kalinina +8 more
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Phenotype and Hierarchy of Two Transgenic T Cell Lines Targeting the Respiratory Syncytial Virus KdM282-90 Epitope Is Transfer Dose-Dependent. [PDF]
PLoS ONE, 2016 In this study, we compared two lines of transgenic CD8+ T cells specific for the same KdM282-90 epitope of respiratory syncytial virus in the CB6F1 hybrid mouse model. Here we found that these two transgenic lines had similar in vivo abilities to control
Kaitlyn M Morabito +3 more
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iScience, 2023 Summary: Adoptive transfer of hepatitis B virus (HBV) immunity may occur following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, we investigated the adoptive transfer of HBV immunity in 112 patients without HBV surface antibody ...
Jinhua Ren +17 more
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iScience, 2020 Summary: The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress hepatitis B virus (HBV) infection. After adoptive transfer, PSC-CTLs can infiltrate into
Mohammad Haque +10 more
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