Results 211 to 220 of about 306,104 (338)

Mechanistic Foundations of KRAS‐Driven Tumor Ecosystems: Integrating Crosstalk among Immune, Metabolic, Microbial, and Stromal Microenvironment

Advanced Science, EarlyView.
KRAS mutations dynamically remodel the tumor microenvironment (TME), fostering immunosuppression, metabolic symbiosis, and stromal plasticity. This review dissects how oncogenic KRAS variants sculpt TME networks and explores actionable vulnerabilities. Emerging strategies combining KRAS inhibitors and TME‐editing approaches offer potential to dismantle
Jiayao Ma, Shenao Fu, Jun Tan, Ying Han, Yihong Chen, Xiangying Deng, Hong Shen, Shan Zeng, Yinghui Peng, Changjing Cai   +9 more
wiley   +1 more source

Use of ¹⁸F‐FDG positron emission tomography following allogeneic transplantation to guide adoptive immunotherapy with donor lymphocyte infusions [PDF]

, 2005
D. P. Hart, Irit Avivi, Kirsty Thomson, Karl S. Peggs, Emma Morris, Anthony H. Goldstone, David C. Linch, Peter J. Ell, Jamshed Bomanji, Stephen Mackinnon   +9 more
openalex   +1 more source

Gene editing technology to improve antitumor T-cell functions in adoptive immunotherapy. [PDF]

Inflamm Regen
Ito Y, Inoue S, Kagoya Y.
europepmc   +1 more source

The Potential of Tissue-Resident Memory T Cells for Adoptive Immunotherapy against Cancer. [PDF]

Cells, 2021
Beumer-Chuwonpad A, Taggenbrock RLRE, Ngo TA, van Gisbergen KPJM.   +3 more
europepmc   +1 more source

An Explainable Multimodal Artificial Intelligence Model Integrating Histopathological Microenvironment and EHR Phenotypes for Germline Genetic Testing in Breast Cancer

Advanced Science, EarlyView.
This study presents an explainable multimodal AI model, MAIGGT (Multimodal Artificial Intelligence Germline Genetic Testing), that combines whole‐slide histopathology with clinical data for accurate germline BRCA1/2 mutation prescreening. By integrating digital pathology and EHR phenotypes, MAIGCT enables cost‐effective, scalable hereditary breast ...
Zijian Yang, Changyuan Guo, Jiayi Li, Yalun Li, Lei Zhong, Pengming Pu, Tongxuan Shang, Lin Cong, Yongxin Zhou, Guangdong Qiao, Ziqi Jia, Hengyi Xu, Heng Cao, Yansong Huang, Tianyi Liu, Jian Liang, Jiang Wu, Dongxu Ma, Yuchen Liu, Ruijie Zhou, Xiang Wang, Jianming Ying, Meng Zhou, Jiaqi Liu   +23 more
wiley   +1 more source

Adoptive Immunotherapy for Malignant Brain Tumors Using Human Peripheral Blood Mononuclear Cells Activated by the Streptococcal Preparation OK-432.

, 2001
Tatsumi Hirotsu, Toshihiro Mineta, Makoto Ichinose, Keisuke Toda, Kouzou Fukuyama, Kazuo Tabuchi   +5 more
openalex   +2 more sources

Adoptive immunotherapy with allodepleted donor T-cells improves immune reconstitution after haploidentical stem cell transplantation [PDF]

, 2006
Persis Amrolia
openalex   +1 more source

A phase I/II study of adoptive immunotherapy using donor liver graft-derived NK cell-enriched immune cells to prevent severe infection after liver transplantation. [PDF]

PLoS One
Ohira M, Imaoka Y, Sato K, Imaoka K, Bekki T, Yano T, Nakano R, Sakai H, Kuroda S, Tahara H, Ide K, Kobayashi T, Tanaka Y, Tanaka J, Ohdan H.   +14 more
europepmc   +1 more source

New Orders to an Old Soldier: Optimizing NK Cells for Adoptive Immunotherapy in Hematology. [PDF]

Biomedicines, 2021
Gunduz M, Ataca Atilla P, Atilla E.
europepmc   +1 more source

Mitochondrial Regulation of CD8⁺ T Cells: Mechanisms and Therapeutic Modulation

Advanced Science, EarlyView.
This article comprehensively explores the pivotal role of mitochondrial function in CD8⁺ T cell immunotherapy. It highlights how mitochondrial dynamics regulate T cell activation, differentiation, and persistence, and how mitochondrial dysfunction leads to immune exhaustion and impaired antitumor/antiviral responses.
Xu Chen, Pei Lin, Ye Lu, Jiarong Zheng, Yunfan Lin, Zihao Zhou, Li Cui, Xinyuan Zhao   +7 more
wiley   +1 more source