Results 211 to 220 of about 310,786 (327)

Adoptive cell-based immunotherapy of cancer

, 2015
Hae Won
openalex   +1 more source

BRAF Inhibition Increases Tumor Infiltration by T cells and Enhances the Antitumor Activity of Adoptive Immunotherapy in Mice [PDF]

, 2012
Chengwen Liu, Weiyi Peng, Chunyu Xu, Yanyan Lou, Minying Zhang, Jennifer A. Wargo, Jie Qing Chen, Haiyan S. Li, Stephanie S. Watowich, Yan Yang, Dennie T. Frederick, Zachary A. Cooper, Rina M. Mbofung, Mayra Whittington, Keith T. Flaherty, Scott E. Woodman, Michael A. Davies, Laszlo Radvanyi, Willem W. Overwijk, Gregory Lizée, Patrick Hwu   +20 more
openalex   +1 more source

scPER: A Rigorous Computational Approach to Determine Cellular Subtypes in Tumors Aligned With Cancer Phenotypes From Total RNA Sequencing

Advanced Science, EarlyView.
scPER presents an adversarial‐autoencoder framework that deconvolves bulk total RNA‐seq to quantify tumor‐microenvironment cell types and uncover phenotype‐linked subclusters. Across diverse benchmarks, scPER improves accuracy over existing tools.
Bingrui Li, Xiaobo Zhou, Raghu Kalluri
wiley   +1 more source

Abrogation of Src Homology Region 2 Domain-Containing Phosphatase 1 in Tumor-Specific T Cells Improves Efficacy of Adoptive Immunotherapy by Enhancing the Effector Function and Accumulation of Short-Lived Effector T Cells In Vivo [PDF]

, 2012
Ingunn M. Stromnes, Carla Fowler, Chanel C. Casamina, Christina M. Georgopolos, Megan S. McAfee, Thomas M. Schmitt, Xiaoxia Tan, Tae‐Don Kim, Inpyo Choi, Joseph N. Blattman, Philip D. Greenberg   +10 more
openalex   +1 more source

Selection bias: Maintaining less-differentiated T cells for adoptive immunotherapy

, 2021
Y. Xu, G. Dotti
openalex   +1 more source

Protease‐Activated Plasmonic Nanosensors for Predictive Ultrasound‐Guided Photoacoustic Imaging of Tumor Responses to Adoptive T Cell Therapy

Advanced Science, EarlyView.
Protease‐activated plasmonic nanosensors are demonstrated to noninvasively monitor antitumor T cell activity in tumors with anatomical information upon adoptive T cell transfer via ultrasound‐guided photoacoustic imaging. These nanosensors are actuated by granzyme B, a protease secreted by activated cytotoxic T cells during tumor cell killing, which ...
Myeongsoo Kim, Seoyoon Song, Ali Zamat, Paul S. Pelkowski, Shivashankar Subramanian, Melissa Cadena, Sydney Fabrega, Meredith Brienen, Jinhwan Kim, Gabriel A. Kwong, Stanislav Y. Emelianov   +10 more
wiley   +1 more source

Optimizing EphA2-CAR T Cells for the Adoptive Immunotherapy of Glioma

Molecular Therapy: Methods & Clinical Development, 2018
Zhongzhen Yi, Brooke Prinzing, Felicia Cao, S. Gottschalk, Giedre Krenciute   +4 more
semanticscholar   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

T cell cancer immunotherapy: Characterisation and manipulation of tumour antigen-specific T cell subsets for adoptive immunotherapy in mouse models

, 2011
Matthew J. White
openalex   +2 more sources

Rebuilding Human Leukocyte Antigen Class II–Restricted Minor Histocompatibility Antigen Specificity in Recall Antigen-Specific T Cells by Adoptive T Cell Receptor Transfer: Implications for Adoptive Immunotherapy [PDF]

, 2007
Robbert M. Spaapen, Kelly van den Oudenalder, Roman Ivanov, Andries C. Bloem, Henk M. Lokhorst, Tuna Mutis   +5 more
openalex   +1 more source